Maternal Obesity, Diabetes Associated With Autism

[Guest guest]

Science News

.... from universities, journals, and other research organizations

Maternal Obesity, Diabetes Associated With Autism, Other Developmental Disorders

ScienceDaily (Apr. 9, 2012) — A major study conducted by researchers affiliated with the UC MIND Institute has found strong links between maternal diabetes and obesity and the likelihood of having a child with autism spectrum disorder (ASD) or another developmental disorder.

The study, which investigated the relationships between maternal metabolic conditions and the risk of neurodevelopmental disorders, found that mothers who were obese were 67 percent more likely to have a child with ASD than normal-weight mothers without diabetes or hypertension, and were more than twice as likely to have a child with another developmental disorder.

Mothers with diabetes were found to have nearly 67 percent more likely to have a child with developmental delays as healthy mothers. However, the proportion of mothers with diabetes who had a child with ASD was higher than in healthy moms but did not reach statistical significance.

The study also found that the children of diabetic mothers who had ASD were more disabled -- had greater deficits in language comprehension and production and adaptive communication -- than were the children with ASD born to healthy mothers.

However, even children without ASD born to diabetic mothers exhibited impairments in socialization in addition to language comprehension and production, when compared with the non-ASD children of healthy women. Children without ASD of mothers with any of the metabolic conditions displayed mild deficits in problem solving, language comprehension and production, motor skills and socialization.

"Over a third of U.S. women in their childbearing years are obese, and nearly one-tenth have gestational or type 2 diabetes during pregnancy. Our finding that these maternal conditions may be linked with neurodevelopmental problems in children raises concerns and therefore may have serious public-health implications," said a Krakowiak, a PhD Candidate in Epidemiology affiliated with the MIND Institute. "And while the study does not conclude that diabetes and obesity cause ASD and developmental delays, it suggests that fetal exposure to elevated glucose and maternal inflammation levels adversely affect fetal development."

The study, "Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders," is published online April 9 in Pediatrics, the Journal of the American Academy of Pediatrics. Its authors said that it is the first study to examine the associations between neurodevelopmental disorders and maternal metabolic conditions not restricted solely to type 2 or gestational diabetes. It is also the first to include obesity and hypertension, which have similar underlying biological characteristics, and to investigate correlations between these conditions and impairments in the skills and abilities of children in specific developmental domains.

Over 60 percent of U.S. women of childbearing age are overweight; 34 percent are obese; and 16 percent have metabolic syndrome. Nearly 9 percent of U.S. women of childbearing age are diabetic, and more than 1 percent of U.S. pregnancies were complicated by chronic hypertension. In California, where the study was conducted, 1.3 percent of women had type 2 diabetes, and 7.4 percent had gestational diabetes.

Autism spectrum disorder is characterized by impairments in social interaction, communication deficits and repetitive behaviors and often is accompanied by intellectual disability. An estimated 1 in 88 children born today will be diagnosed with autism spectrum disorder, according to statistics recently released by the U.S. Centers for Disease Control and Prevention. An estimated 1 in 83 U.S. children has another developmental disorder, which includes other disorders resulting in intellectual disability.

The study included 1,004 mother/child pairs from diverse backgrounds enrolled in the Childhood Autism Risks from Genetics and the Environment Study (CHARGE), most of them living in Northern California, with a small subset living in Los Angeles. The children were between 24 and 60 months old, born in California and resided with at least one biological parent who spoke either English or Spanish. There were 517 children who had ASD; 172 who had other developmental disorders but not ASD; and 315 who were developing typically. The participants were enrolled between January 2003 and June 2010.

The researchers obtained demographic and medical information for the mothers and their children using the CHARGE Study Environmental Exposure Questionnaire, a telephone survey, the study participants' birth files and medical records. The primary metabolic conditions of interest were type 2 diabetes or gestational diabetes.

Women were considered diabetic if the condition was noted in their medical records or if during the telephone surveys they answered "yes" to the questions "During this pregnancy were you ever told by a physician or nurse that you had gestational diabetes?" or "At any time before you became pregnant were you told by a doctor that you had [type 2] diabetes?" The same wording was used to obtain information about hypertension. BMI was calculated using height and weight prior to pregnancy from medical records or telephone interviews.

To confirm the developmental diagnoses of the children with ASD researchers used the Autism Diagnostic Interview-Revised (ADIR) and the Autism Diagnostic Observation Schedules (ADOS). All of the children were administered the Mullen Sales of Early Learning and the Vineland Adaptive Behavior Scales to assess their cognitive and adaptive development Spanish-speaking children were administered the tests in Spanish. The participants were then divided into groups of children with ASD, developmental delay or typical development.

Among children whose mothers were diabetic during their pregnancies, the study found that the percentage of children with ASD born to women with type 2 diabetes or gestational diabetes (9.3 percent) or developmental disability (11.6 percent) was higher than the 6.4 percent of children with ASD born to women without these metabolic conditions.

Over 20 percent of the mothers of children with ASD or developmental delay were obese, compared with 14 percent of the mothers of typically developing children.

Approximately 29 percent of the children with ASD had mothers with a metabolic condition, and nearly 35 percent of the children with developmental delay had mothers with metabolic conditions. In contrast, 19 percent of the typically developing children had mothers with a metabolic condition.

The study also examined the link between hypertension and ASD or developmental disorders. The prevalence of high blood pressure was low for all groups, but more than two times higher among mothers of children with ASD or developmental delay than among mothers of children with typical development, though the finding did not reach statistical significance.

Analyses of the children's cognitive abilities found that, among the children with ASD, children of mothers with diabetes exhibited poorer performance on tests of expressive and receptive language and communication skills of everyday living when compared with the children of healthy mothers. And the presence of any metabolic condition was associated with lower scores on all of the tests among children without ASD.

The authors note that obesity is a significant risk factor for diabetes and hypertension, and is characterized by increased insulin resistance and chronic inflammation, as are diabetes and hypertension. In diabetic, and possibility pre-diabetic pregnancies, poorly regulated maternal glucose can result in prolonged fetal exposure to elevated maternal glucose levels, which raises fetal insulin production, resulting in chronic fetal exposure to high levels of insulin.

Because elevated insulin production requires greater oxygen use this may result in depleted oxygen supply for the fetus. Diabetes also may result in fetal iron deficiency. Both conditions can adversely affect fetal brain development, the authors said.

"The sequence of events related to poorly regulated maternal glucose levels is one potential biological mechanism that may play a role in adverse fetal development in the presence of maternal metabolic conditions," Krakowiak said.

Maternal inflammation, which accompanies metabolic conditions, may also adversely affect fetal development. Certain proteins involved in cell signaling that are produced by cells of the immune system can cross the placenta from the mother to the fetus and disturb brain development.

Other study authors are Irva Hertz-Picciotto, Cheryl , Alice Baker, Sally Ozonoff and Robin Hansen of the UC MIND Institute and Bremer of UC and Vanderbilt University.

The study was supported by the National Institutes of Health (P01 ES11269 and R01 ES015359), the U.S. Environmental Protection Agency through the Science to Achieve Results (STAR) program (R829388 and R833292), and the UC MIND Institute.

[Guest guest]



probably the same percentage was watching The Kardashians. should we assume that watching the Kardashians causes Autism.

I am sooooo sick and tired of these meaningless research and studies.

Remember few years ago..watching TV causes autism .....

btw: I weighed 140 pounds when I got pregnant with my son and I am 5 feet six inches tall.

Maternal Obesity, Diabetes Associated With Autism

Science News

.... from universities, journals, and other research organizations

Maternal Obesity, Diabetes Associated With Autism, Other Developmental Disorders

ScienceDaily (Apr. 9, 2012) — A major study conducted by researchers affiliated with the UC MIND Institute has found strong links between maternal diabetes and obesity and the likelihood of having a child with autism spectrum disorder (ASD) or another developmental disorder.

The study, which investigated the relationships between maternal metabolic conditions and the risk of neurodevelopmental disorders, found that mothers who were obese were 67 percent more likely to have a child with ASD than normal-weight mothers without diabetes or hypertension, and were more than twice as likely to have a child with another developmental disorder.

Mothers with diabetes were found to have nearly 67 percent more likely to have a child with developmental delays as healthy mothers. However, the proportion of mothers with diabetes who had a child with ASD was higher than in healthy moms but did not reach statistical significance.

The study also found that the children of diabetic mothers who had ASD were more disabled -- had greater deficits in language comprehension and production and adaptive communication -- than were the children with ASD born to healthy mothers.

However, even children without ASD born to diabetic mothers exhibited impairments in socialization in addition to language comprehension and production, when compared with the non-ASD children of healthy women. Children without ASD of mothers with any of the metabolic conditions displayed mild deficits in problem solving, language comprehension and production, motor skills and socialization.

"Over a third of U.S. women in their childbearing years are obese, and nearly one-tenth have gestational or type 2 diabetes during pregnancy. Our finding that these maternal conditions may be linked with neurodevelopmental problems in children raises concerns and therefore may have serious public-health implications," said a Krakowiak, a PhD Candidate in Epidemiology affiliated with the MIND Institute. "And while the study does not conclude that diabetes and obesity cause ASD and developmental delays, it suggests that fetal exposure to elevated glucose and maternal inflammation levels adversely affect fetal development."

The study, "Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders," is published online April 9 in Pediatrics, the Journal of the American Academy of Pediatrics. Its authors said that it is the first study to examine the associations between neurodevelopmental disorders and maternal metabolic conditions not restricted solely to type 2 or gestational diabetes. It is also the first to include obesity and hypertension, which have similar underlying biological characteristics, and to investigate correlations between these conditions and impairments in the skills and abilities of children in specific developmental domains.

Over 60 percent of U.S. women of childbearing age are overweight; 34 percent are obese; and 16 percent have metabolic syndrome. Nearly 9 percent of U.S. women of childbearing age are diabetic, and more than 1 percent of U.S. pregnancies were complicated by chronic hypertension. In California, where the study was conducted, 1.3 percent of women had type 2 diabetes, and 7.4 percent had gestational diabetes.

Autism spectrum disorder is characterized by impairments in social interaction, communication deficits and repetitive behaviors and often is accompanied by intellectual disability. An estimated 1 in 88 children born today will be diagnosed with autism spectrum disorder, according to statistics recently released by the U.S. Centers for Disease Control and Prevention. An estimated 1 in 83 U.S. children has another developmental disorder, which includes other disorders resulting in intellectual disability.

The study included 1,004 mother/child pairs from diverse backgrounds enrolled in the Childhood Autism Risks from Genetics and the Environment Study (CHARGE), most of them living in Northern California, with a small subset living in Los Angeles. The children were between 24 and 60 months old, born in California and resided with at least one biological parent who spoke either English or Spanish. There were 517 children who had ASD; 172 who had other developmental disorders but not ASD; and 315 who were developing typically. The participants were enrolled between January 2003 and June 2010.

The researchers obtained demographic and medical information for the mothers and their children using the CHARGE Study Environmental Exposure Questionnaire, a telephone survey, the study participants' birth files and medical records. The primary metabolic conditions of interest were type 2 diabetes or gestational diabetes.

Women were considered diabetic if the condition was noted in their medical records or if during the telephone surveys they answered "yes" to the questions "During this pregnancy were you ever told by a physician or nurse that you had gestational diabetes?" or "At any time before you became pregnant were you told by a doctor that you had [type 2] diabetes?" The same wording was used to obtain information about hypertension. BMI was calculated using height and weight prior to pregnancy from medical records or telephone interviews.

To confirm the developmental diagnoses of the children with ASD researchers used the Autism Diagnostic Interview-Revised (ADIR) and the Autism Diagnostic Observation Schedules (ADOS). All of the children were administered the Mullen Sales of Early Learning and the Vineland Adaptive Behavior Scales to assess their cognitive and adaptive development Spanish-speaking children were administered the tests in Spanish. The participants were then divided into groups of children with ASD, developmental delay or typical development.

Among children whose mothers were diabetic during their pregnancies, the study found that the percentage of children with ASD born to women with type 2 diabetes or gestational diabetes (9.3 percent) or developmental disability (11.6 percent) was higher than the 6.4 percent of children with ASD born to women without these metabolic conditions.

Over 20 percent of the mothers of children with ASD or developmental delay were obese, compared with 14 percent of the mothers of typically developing children.

Approximately 29 percent of the children with ASD had mothers with a metabolic condition, and nearly 35 percent of the children with developmental delay had mothers with metabolic conditions. In contrast, 19 percent of the typically developing children had mothers with a metabolic condition.

The study also examined the link between hypertension and ASD or developmental disorders. The prevalence of high blood pressure was low for all groups, but more than two times higher among mothers of children with ASD or developmental delay than among mothers of children with typical development, though the finding did not reach statistical significance.

Analyses of the children's cognitive abilities found that, among the children with ASD, children of mothers with diabetes exhibited poorer performance on tests of expressive and receptive language and communication skills of everyday living when compared with the children of healthy mothers. And the presence of any metabolic condition was associated with lower scores on all of the tests among children without ASD.

The authors note that obesity is a significant risk factor for diabetes and hypertension, and is characterized by increased insulin resistance and chronic inflammation, as are diabetes and hypertension. In diabetic, and possibility pre-diabetic pregnancies, poorly regulated maternal glucose can result in prolonged fetal exposure to elevated maternal glucose levels, which raises fetal insulin production, resulting in chronic fetal exposure to high levels of insulin.

Because elevated insulin production requires greater oxygen use this may result in depleted oxygen supply for the fetus. Diabetes also may result in fetal iron deficiency. Both conditions can adversely affect fetal brain development, the authors said.

"The sequence of events related to poorly regulated maternal glucose levels is one potential biological mechanism that may play a role in adverse fetal development in the presence of maternal metabolic conditions," Krakowiak said.

Maternal inflammation, which accompanies metabolic conditions, may also adversely affect fetal development. Certain proteins involved in cell signaling that are produced by cells of the immune system can cross the placenta from the mother to the fetus and disturb brain development.

Other study authors are Irva Hertz-Picciotto, Cheryl , Alice Baker, Sally Ozonoff and Robin Hansen of the UC MIND Institute and Bremer of UC and Vanderbilt University.

The study was supported by the National Institutes of Health (P01 ES11269 and R01 ES015359), the U.S. Environmental Protection Agency through the Science to Achieve Results (STAR) program (R829388 and R833292), and the UC MIND Institute.

[Guest guest]

I'm right there with 'ya! I'm tired of hearing all of the things us mothers MAY have done to cause their child's Autism! My sister-in-law was morbidly obese & had gestational diabetes when pregnant with her twin girls who were also born 6 weeks early & both weighed under 4 lbs at birth- neither 1 has Autism. (They were born just a month before my son- who was born after a full-term pregnancy, I might add). Yet my seemingly "perfect" pregnancy produced a severely Autistic son 15 months after birth & a toddler who hit EVERY milestone early or on time until that point!? Reeks of "Refrigerator Mother" theory to me... Sent from my iPhone



probably the same percentage was watching The Kardashians. should we assume that watching the Kardashians causes Autism.

I am sooooo sick and tired of these meaningless research and studies.

Remember few years ago..watching TV causes autism .....

btw: I weighed 140 pounds when I got pregnant with my son and I am 5 feet six inches tall.

Maternal Obesity, Diabetes Associated With Autism

Science News

.... from universities, journals, and other research organizations

Maternal Obesity, Diabetes Associated With Autism, Other Developmental Disorders

ScienceDaily (Apr. 9, 2012) — A major study conducted by researchers affiliated with the UC MIND Institute has found strong links between maternal diabetes and obesity and the likelihood of having a child with autism spectrum disorder (ASD) or another developmental disorder.

The study, which investigated the relationships between maternal metabolic conditions and the risk of neurodevelopmental disorders, found that mothers who were obese were 67 percent more likely to have a child with ASD than normal-weight mothers without diabetes or hypertension, and were more than twice as likely to have a child with another developmental disorder.

Mothers with diabetes were found to have nearly 67 percent more likely to have a child with developmental delays as healthy mothers. However, the proportion of mothers with diabetes who had a child with ASD was higher than in healthy moms but did not reach statistical significance.

The study also found that the children of diabetic mothers who had ASD were more disabled -- had greater deficits in language comprehension and production and adaptive communication -- than were the children with ASD born to healthy mothers.

However, even children without ASD born to diabetic mothers exhibited impairments in socialization in addition to language comprehension and production, when compared with the non-ASD children of healthy women. Children without ASD of mothers with any of the metabolic conditions displayed mild deficits in problem solving, language comprehension and production, motor skills and socialization.

"Over a third of U.S. women in their childbearing years are obese, and nearly one-tenth have gestational or type 2 diabetes during pregnancy. Our finding that these maternal conditions may be linked with neurodevelopmental problems in children raises concerns and therefore may have serious public-health implications," said a Krakowiak, a PhD Candidate in Epidemiology affiliated with the MIND Institute. "And while the study does not conclude that diabetes and obesity cause ASD and developmental delays, it suggests that fetal exposure to elevated glucose and maternal inflammation levels adversely affect fetal development."

The study, "Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders," is published online April 9 in Pediatrics, the Journal of the American Academy of Pediatrics. Its authors said that it is the first study to examine the associations between neurodevelopmental disorders and maternal metabolic conditions not restricted solely to type 2 or gestational diabetes. It is also the first to include obesity and hypertension, which have similar underlying biological characteristics, and to investigate correlations between these conditions and impairments in the skills and abilities of children in specific developmental domains.

Over 60 percent of U.S. women of childbearing age are overweight; 34 percent are obese; and 16 percent have metabolic syndrome. Nearly 9 percent of U.S. women of childbearing age are diabetic, and more than 1 percent of U.S. pregnancies were complicated by chronic hypertension. In California, where the study was conducted, 1.3 percent of women had type 2 diabetes, and 7.4 percent had gestational diabetes.

Autism spectrum disorder is characterized by impairments in social interaction, communication deficits and repetitive behaviors and often is accompanied by intellectual disability. An estimated 1 in 88 children born today will be diagnosed with autism spectrum disorder, according to statistics recently released by the U.S. Centers for Disease Control and Prevention. An estimated 1 in 83 U.S. children has another developmental disorder, which includes other disorders resulting in intellectual disability.

The study included 1,004 mother/child pairs from diverse backgrounds enrolled in the Childhood Autism Risks from Genetics and the Environment Study (CHARGE), most of them living in Northern California, with a small subset living in Los Angeles. The children were between 24 and 60 months old, born in California and resided with at least one biological parent who spoke either English or Spanish. There were 517 children who had ASD; 172 who had other developmental disorders but not ASD; and 315 who were developing typically. The participants were enrolled between January 2003 and June 2010.

The researchers obtained demographic and medical information for the mothers and their children using the CHARGE Study Environmental Exposure Questionnaire, a telephone survey, the study participants' birth files and medical records. The primary metabolic conditions of interest were type 2 diabetes or gestational diabetes.

Women were considered diabetic if the condition was noted in their medical records or if during the telephone surveys they answered "yes" to the questions "During this pregnancy were you ever told by a physician or nurse that you had gestational diabetes?" or "At any time before you became pregnant were you told by a doctor that you had [type 2] diabetes?" The same wording was used to obtain information about hypertension. BMI was calculated using height and weight prior to pregnancy from medical records or telephone interviews.

To confirm the developmental diagnoses of the children with ASD researchers used the Autism Diagnostic Interview-Revised (ADIR) and the Autism Diagnostic Observation Schedules (ADOS). All of the children were administered the Mullen Sales of Early Learning and the Vineland Adaptive Behavior Scales to assess their cognitive and adaptive development Spanish-speaking children were administered the tests in Spanish. The participants were then divided into groups of children with ASD, developmental delay or typical development.

Among children whose mothers were diabetic during their pregnancies, the study found that the percentage of children with ASD born to women with type 2 diabetes or gestational diabetes (9.3 percent) or developmental disability (11.6 percent) was higher than the 6.4 percent of children with ASD born to women without these metabolic conditions.

Over 20 percent of the mothers of children with ASD or developmental delay were obese, compared with 14 percent of the mothers of typically developing children.

Approximately 29 percent of the children with ASD had mothers with a metabolic condition, and nearly 35 percent of the children with developmental delay had mothers with metabolic conditions. In contrast, 19 percent of the typically developing children had mothers with a metabolic condition.

The study also examined the link between hypertension and ASD or developmental disorders. The prevalence of high blood pressure was low for all groups, but more than two times higher among mothers of children with ASD or developmental delay than among mothers of children with typical development, though the finding did not reach statistical significance.

Analyses of the children's cognitive abilities found that, among the children with ASD, children of mothers with diabetes exhibited poorer performance on tests of expressive and receptive language and communication skills of everyday living when compared with the children of healthy mothers. And the presence of any metabolic condition was associated with lower scores on all of the tests among children without ASD.

The authors note that obesity is a significant risk factor for diabetes and hypertension, and is characterized by increased insulin resistance and chronic inflammation, as are diabetes and hypertension. In diabetic, and possibility pre-diabetic pregnancies, poorly regulated maternal glucose can result in prolonged fetal exposure to elevated maternal glucose levels, which raises fetal insulin production, resulting in chronic fetal exposure to high levels of insulin.

Because elevated insulin production requires greater oxygen use this may result in depleted oxygen supply for the fetus. Diabetes also may result in fetal iron deficiency. Both conditions can adversely affect fetal brain development, the authors said.

"The sequence of events related to poorly regulated maternal glucose levels is one potential biological mechanism that may play a role in adverse fetal development in the presence of maternal metabolic conditions," Krakowiak said.

Maternal inflammation, which accompanies metabolic conditions, may also adversely affect fetal development. Certain proteins involved in cell signaling that are produced by cells of the immune system can cross the placenta from the mother to the fetus and disturb brain development.

Other study authors are Irva Hertz-Picciotto, Cheryl , Alice Baker, Sally Ozonoff and Robin Hansen of the UC MIND Institute and Bremer of UC and Vanderbilt University.

The study was supported by the National Institutes of Health (P01 ES11269 and R01 ES015359), the U.S. Environmental Protection Agency through the Science to Achieve Results (STAR) program (R829388 and R833292), and the UC MIND Institute.

=

[Guest guest]

I was interviewed regarding that yesterday. Here is the link: http://abclocal.go.com/ktrk/story?section=news%2Fhealth & id=8613526 

 

I'm right there with 'ya! I'm tired of hearing all of the things us mothers MAY have done to cause their child's Autism! My sister-in-law was morbidly obese & had gestational diabetes when pregnant with her twin girls who were also born 6 weeks early & both weighed under 4 lbs at birth- neither 1 has Autism. (They were born just a month before my son- who was born after a full-term pregnancy, I might add). Yet my seemingly " perfect " pregnancy produced a severely Autistic son 15 months after birth & a toddler who hit EVERY milestone early or on time until that point!? Reeks of " Refrigerator Mother " theory to me...

 Sent from my iPhone

 



probably the same percentage was watching The Kardashians.  should we assume that watching the Kardashians causes Autism.

 

I am sooooo sick and tired of these meaningless research and studies.

 

Remember few years ago..watching TV causes  autism .....

 

 

btw:  I weighed 140 pounds when I got pregnant with my son and I am 5 feet six inches tall.

 

Maternal Obesity, Diabetes Associated With Autism

Science News

.... from universities, journals, and other research organizations

Maternal Obesity, Diabetes Associated With Autism, Other Developmental Disorders

ScienceDaily (Apr. 9, 2012) — A major study conducted by researchers affiliated with the UC MIND Institute has found strong links between maternal diabetes and obesity and the likelihood of having a child with autism spectrum disorder (ASD) or another developmental disorder.

The study, which investigated the relationships between maternal metabolic conditions and the risk of neurodevelopmental disorders, found that mothers who were obese were 67 percent more likely to have a child with ASD than normal-weight mothers without diabetes or hypertension, and were more than twice as likely to have a child with another developmental disorder.

Mothers with diabetes were found to have nearly 67 percent more likely to have a child with developmental delays as healthy mothers. However, the proportion of mothers with diabetes who had a child with ASD was higher than in healthy moms but did not reach statistical significance.

The study also found that the children of diabetic mothers who had ASD were more disabled -- had greater deficits in language comprehension and production and adaptive communication -- than were the children with ASD born to healthy mothers.

However, even children without ASD born to diabetic mothers exhibited impairments in socialization in addition to language comprehension and production, when compared with the non-ASD children of healthy women. Children without ASD of mothers with any of the metabolic conditions displayed mild deficits in problem solving, language comprehension and production, motor skills and socialization.

" Over a third of U.S. women in their childbearing years are obese, and nearly one-tenth have gestational or type 2 diabetes during pregnancy. Our finding that these maternal conditions may be linked with neurodevelopmental problems in children raises concerns and therefore may have serious public-health implications, " said a Krakowiak, a PhD Candidate in Epidemiology affiliated with the MIND Institute. " And while the study does not conclude that diabetes and obesity cause ASD and developmental delays, it suggests that fetal exposure to elevated glucose and maternal inflammation levels adversely affect fetal development. "

The study, " Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders, " is published online April 9 in Pediatrics, the Journal of the American Academy of Pediatrics. Its authors said that it is the first study to examine the associations between neurodevelopmental disorders and maternal metabolic conditions not restricted solely to type 2 or gestational diabetes. It is also the first to include obesity and hypertension, which have similar underlying biological characteristics, and to investigate correlations between these conditions and impairments in the skills and abilities of children in specific developmental domains.

Over 60 percent of U.S. women of childbearing age are overweight; 34 percent are obese; and 16 percent have metabolic syndrome. Nearly 9 percent of U.S. women of childbearing age are diabetic, and more than 1 percent of U.S. pregnancies were complicated by chronic hypertension. In California, where the study was conducted, 1.3 percent of women had type 2 diabetes, and 7.4 percent had gestational diabetes.

Autism spectrum disorder is characterized by impairments in social interaction, communication deficits and repetitive behaviors and often is accompanied by intellectual disability. An estimated 1 in 88 children born today will be diagnosed with autism spectrum disorder, according to statistics recently released by the U.S. Centers for Disease Control and Prevention. An estimated 1 in 83 U.S. children has another developmental disorder, which includes other disorders resulting in intellectual disability.

The study included 1,004 mother/child pairs from diverse backgrounds enrolled in the Childhood Autism Risks from Genetics and the Environment Study (CHARGE), most of them living in Northern California, with a small subset living in Los Angeles. The children were between 24 and 60 months old, born in California and resided with at least one biological parent who spoke either English or Spanish. There were 517 children who had ASD; 172 who had other developmental disorders but not ASD; and 315 who were developing typically. The participants were enrolled between January 2003 and June 2010.

The researchers obtained demographic and medical information for the mothers and their children using the CHARGE Study Environmental Exposure Questionnaire, a telephone survey, the study participants' birth files and medical records. The primary metabolic conditions of interest were type 2 diabetes or gestational diabetes.

Women were considered diabetic if the condition was noted in their medical records or if during the telephone surveys they answered " yes " to the questions " During this pregnancy were you ever told by a physician or nurse that you had gestational diabetes? " or " At any time before you became pregnant were you told by a doctor that you had [type 2] diabetes? " The same wording was used to obtain information about hypertension. BMI was calculated using height and weight prior to pregnancy from medical records or telephone interviews.

To confirm the developmental diagnoses of the children with ASD researchers used the Autism Diagnostic Interview-Revised (ADIR) and the Autism Diagnostic Observation Schedules (ADOS). All of the children were administered the Mullen Sales of Early Learning and the Vineland Adaptive Behavior Scales to assess their cognitive and adaptive development Spanish-speaking children were administered the tests in Spanish. The participants were then divided into groups of children with ASD, developmental delay or typical development.

Among children whose mothers were diabetic during their pregnancies, the study found that the percentage of children with ASD born to women with type 2 diabetes or gestational diabetes (9.3 percent) or developmental disability (11.6 percent) was higher than the 6.4 percent of children with ASD born to women without these metabolic conditions.

Over 20 percent of the mothers of children with ASD or developmental delay were obese, compared with 14 percent of the mothers of typically developing children.

Approximately 29 percent of the children with ASD had mothers with a metabolic condition, and nearly 35 percent of the children with developmental delay had mothers with metabolic conditions. In contrast, 19 percent of the typically developing children had mothers with a metabolic condition.

The study also examined the link between hypertension and ASD or developmental disorders. The prevalence of high blood pressure was low for all groups, but more than two times higher among mothers of children with ASD or developmental delay than among mothers of children with typical development, though the finding did not reach statistical significance.

Analyses of the children's cognitive abilities found that, among the children with ASD, children of mothers with diabetes exhibited poorer performance on tests of expressive and receptive language and communication skills of everyday living when compared with the children of healthy mothers. And the presence of any metabolic condition was associated with lower scores on all of the tests among children without ASD.

The authors note that obesity is a significant risk factor for diabetes and hypertension, and is characterized by increased insulin resistance and chronic inflammation, as are diabetes and hypertension. In diabetic, and possibility pre-diabetic pregnancies, poorly regulated maternal glucose can result in prolonged fetal exposure to elevated maternal glucose levels, which raises fetal insulin production, resulting in chronic fetal exposure to high levels of insulin.

Because elevated insulin production requires greater oxygen use this may result in depleted oxygen supply for the fetus. Diabetes also may result in fetal iron deficiency. Both conditions can adversely affect fetal brain development, the authors said.

" The sequence of events related to poorly regulated maternal glucose levels is one potential biological mechanism that may play a role in adverse fetal development in the presence of maternal metabolic conditions, " Krakowiak said.

Maternal inflammation, which accompanies metabolic conditions, may also adversely affect fetal development. Certain proteins involved in cell signaling that are produced by cells of the immune system can cross the placenta from the mother to the fetus and disturb brain development.

Other study authors are Irva Hertz-Picciotto, Cheryl , Alice Baker, Sally Ozonoff and Robin Hansen of the UC MIND Institute and Bremer of UC and Vanderbilt University.

The study was supported by the National Institutes of Health (P01 ES11269 and R01 ES015359), the U.S. Environmental Protection Agency through the Science to Achieve Results (STAR) program (R829388 and R833292), and the UC MIND Institute.

=

[Guest guest]

Excellent input, . Let's concentrate on meaningful therapies to help those already diagnosed as well as trying to pinpoint the causes of Autism. However, most people in the mainstream will still think- overweight pregnant moms= higher chance of having a child with Autism based on the "results" of this study. Sent from my iPhone

I was interviewed regarding that yesterday. Here is the link: http://abclocal.go.com/ktrk/story?section=news%2Fhealth & id=8613526

I'm right there with 'ya! I'm tired of hearing all of the things us mothers MAY have done to cause their child's Autism! My sister-in-law was morbidly obese & had gestational diabetes when pregnant with her twin girls who were also born 6 weeks early & both weighed under 4 lbs at birth- neither 1 has Autism. (They were born just a month before my son- who was born after a full-term pregnancy, I might add). Yet my seemingly "perfect" pregnancy produced a severely Autistic son 15 months after birth & a toddler who hit EVERY milestone early or on time until that point!? Reeks of "Refrigerator Mother" theory to me...

Sent from my iPhone



probably the same percentage was watching The Kardashians. should we assume that watching the Kardashians causes Autism.

I am sooooo sick and tired of these meaningless research and studies.

Remember few years ago..watching TV causes autism .....

btw: I weighed 140 pounds when I got pregnant with my son and I am 5 feet six inches tall.

Maternal Obesity, Diabetes Associated With Autism

Science News

.... from universities, journals, and other research organizations

Maternal Obesity, Diabetes Associated With Autism, Other Developmental Disorders

ScienceDaily (Apr. 9, 2012) — A major study conducted by researchers affiliated with the UC MIND Institute has found strong links between maternal diabetes and obesity and the likelihood of having a child with autism spectrum disorder (ASD) or another developmental disorder.

The study, which investigated the relationships between maternal metabolic conditions and the risk of neurodevelopmental disorders, found that mothers who were obese were 67 percent more likely to have a child with ASD than normal-weight mothers without diabetes or hypertension, and were more than twice as likely to have a child with another developmental disorder.

Mothers with diabetes were found to have nearly 67 percent more likely to have a child with developmental delays as healthy mothers. However, the proportion of mothers with diabetes who had a child with ASD was higher than in healthy moms but did not reach statistical significance.

The study also found that the children of diabetic mothers who had ASD were more disabled -- had greater deficits in language comprehension and production and adaptive communication -- than were the children with ASD born to healthy mothers.

However, even children without ASD born to diabetic mothers exhibited impairments in socialization in addition to language comprehension and production, when compared with the non-ASD children of healthy women. Children without ASD of mothers with any of the metabolic conditions displayed mild deficits in problem solving, language comprehension and production, motor skills and socialization.

"Over a third of U.S. women in their childbearing years are obese, and nearly one-tenth have gestational or type 2 diabetes during pregnancy. Our finding that these maternal conditions may be linked with neurodevelopmental problems in children raises concerns and therefore may have serious public-health implications," said a Krakowiak, a PhD Candidate in Epidemiology affiliated with the MIND Institute. "And while the study does not conclude that diabetes and obesity cause ASD and developmental delays, it suggests that fetal exposure to elevated glucose and maternal inflammation levels adversely affect fetal development."

The study, "Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders," is published online April 9 in Pediatrics, the Journal of the American Academy of Pediatrics. Its authors said that it is the first study to examine the associations between neurodevelopmental disorders and maternal metabolic conditions not restricted solely to type 2 or gestational diabetes. It is also the first to include obesity and hypertension, which have similar underlying biological characteristics, and to investigate correlations between these conditions and impairments in the skills and abilities of children in specific developmental domains.

Over 60 percent of U.S. women of childbearing age are overweight; 34 percent are obese; and 16 percent have metabolic syndrome. Nearly 9 percent of U.S. women of childbearing age are diabetic, and more than 1 percent of U.S. pregnancies were complicated by chronic hypertension. In California, where the study was conducted, 1.3 percent of women had type 2 diabetes, and 7.4 percent had gestational diabetes.

Autism spectrum disorder is characterized by impairments in social interaction, communication deficits and repetitive behaviors and often is accompanied by intellectual disability. An estimated 1 in 88 children born today will be diagnosed with autism spectrum disorder, according to statistics recently released by the U.S. Centers for Disease Control and Prevention. An estimated 1 in 83 U.S. children has another developmental disorder, which includes other disorders resulting in intellectual disability.

The study included 1,004 mother/child pairs from diverse backgrounds enrolled in the Childhood Autism Risks from Genetics and the Environment Study (CHARGE), most of them living in Northern California, with a small subset living in Los Angeles. The children were between 24 and 60 months old, born in California and resided with at least one biological parent who spoke either English or Spanish. There were 517 children who had ASD; 172 who had other developmental disorders but not ASD; and 315 who were developing typically. The participants were enrolled between January 2003 and June 2010.

The researchers obtained demographic and medical information for the mothers and their children using the CHARGE Study Environmental Exposure Questionnaire, a telephone survey, the study participants' birth files and medical records. The primary metabolic conditions of interest were type 2 diabetes or gestational diabetes.

Women were considered diabetic if the condition was noted in their medical records or if during the telephone surveys they answered "yes" to the questions "During this pregnancy were you ever told by a physician or nurse that you had gestational diabetes?" or "At any time before you became pregnant were you told by a doctor that you had [type 2] diabetes?" The same wording was used to obtain information about hypertension. BMI was calculated using height and weight prior to pregnancy from medical records or telephone interviews.

To confirm the developmental diagnoses of the children with ASD researchers used the Autism Diagnostic Interview-Revised (ADIR) and the Autism Diagnostic Observation Schedules (ADOS). All of the children were administered the Mullen Sales of Early Learning and the Vineland Adaptive Behavior Scales to assess their cognitive and adaptive development Spanish-speaking children were administered the tests in Spanish. The participants were then divided into groups of children with ASD, developmental delay or typical development.

Among children whose mothers were diabetic during their pregnancies, the study found that the percentage of children with ASD born to women with type 2 diabetes or gestational diabetes (9.3 percent) or developmental disability (11.6 percent) was higher than the 6.4 percent of children with ASD born to women without these metabolic conditions.

Over 20 percent of the mothers of children with ASD or developmental delay were obese, compared with 14 percent of the mothers of typically developing children.

Approximately 29 percent of the children with ASD had mothers with a metabolic condition, and nearly 35 percent of the children with developmental delay had mothers with metabolic conditions. In contrast, 19 percent of the typically developing children had mothers with a metabolic condition.

The study also examined the link between hypertension and ASD or developmental disorders. The prevalence of high blood pressure was low for all groups, but more than two times higher among mothers of children with ASD or developmental delay than among mothers of children with typical development, though the finding did not reach statistical significance.

Analyses of the children's cognitive abilities found that, among the children with ASD, children of mothers with diabetes exhibited poorer performance on tests of expressive and receptive language and communication skills of everyday living when compared with the children of healthy mothers. And the presence of any metabolic condition was associated with lower scores on all of the tests among children without ASD.

The authors note that obesity is a significant risk factor for diabetes and hypertension, and is characterized by increased insulin resistance and chronic inflammation, as are diabetes and hypertension. In diabetic, and possibility pre-diabetic pregnancies, poorly regulated maternal glucose can result in prolonged fetal exposure to elevated maternal glucose levels, which raises fetal insulin production, resulting in chronic fetal exposure to high levels of insulin.

Because elevated insulin production requires greater oxygen use this may result in depleted oxygen supply for the fetus. Diabetes also may result in fetal iron deficiency. Both conditions can adversely affect fetal brain development, the authors said.

"The sequence of events related to poorly regulated maternal glucose levels is one potential biological mechanism that may play a role in adverse fetal development in the presence of maternal metabolic conditions," Krakowiak said.

[Guest guest]

Alternatively, some value may come from this in the association of diabetes with autism in children. Diabetes is a metabolic disorder. There's a great deal of research related to metabolic/mitochondrial disorders/dysfunction and the link to autism. You can't move from association to causation with the study below (we hope) but it can still add value to the discussion.

Byrne

To: "Texas-Autism-Advocacy " <Texas-Autism-Advocacy > Sent: Tuesday, April 10, 2012 11:33 AMSubject: Re: Maternal Obesity, Diabetes Associated With Autism

Excellent input, . Let's concentrate on meaningful therapies to help those already diagnosed as well as trying to pinpoint the causes of Autism. However, most people in the mainstream will still think- overweight pregnant moms= higher chance of having a child with Autism based on the "results" of this study. Sent from my iPhone

I was interviewed regarding that yesterday. Here is the link: http://t.co/aGyPMynk

I'm right there with 'ya! I'm tired of hearing all of the things us mothers MAY have done to cause their child's Autism! My sister-in-law was morbidly obese & had gestational diabetes when pregnant with her twin girls who were also born 6 weeks early & both weighed under 4 lbs at birth- neither 1 has Autism. (They were born just a month before my son- who was born after a full-term pregnancy, I might add). Yet my seemingly "perfect" pregnancy produced a severely Autistic son 15 months after birth & a toddler who hit EVERY milestone early or on time until that point!? Reeks of "Refrigerator Mother" theory to me...

Sent from my iPhone



probably the same percentage was watching The Kardashians. should we assume that watching the Kardashians causes Autism.

I am sooooo sick and tired of these meaningless research and studies.

Remember few years ago..watching TV causes autism .....

btw: I weighed 140 pounds when I got pregnant with my son and I am 5 feet six inches tall.

Maternal Obesity, Diabetes Associated With Autism

Science News

.... from universities, journals, and other research organizations

Maternal Obesity, Diabetes Associated With Autism, Other Developmental Disorders

ScienceDaily (Apr. 9, 2012) — A major study conducted by researchers affiliated with the UC MIND Institute has found strong links between maternal diabetes and obesity and the likelihood of having a child with autism spectrum disorder (ASD) or another developmental disorder.

The study, which investigated the relationships between maternal metabolic conditions and the risk of neurodevelopmental disorders, found that mothers who were obese were 67 percent more likely to have a child with ASD than normal-weight mothers without diabetes or hypertension, and were more than twice as likely to have a child with another developmental disorder.

Mothers with diabetes were found to have nearly 67 percent more likely to have a child with developmental delays as healthy mothers. However, the proportion of mothers with diabetes who had a child with ASD was higher than in healthy moms but did not reach statistical significance.

The study also found that the children of diabetic mothers who had ASD were more disabled -- had greater deficits in language comprehension and production and adaptive communication -- than were the children with ASD born to healthy mothers.

However, even children without ASD born to diabetic mothers exhibited impairments in socialization in addition to language comprehension and production, when compared with the non-ASD children of healthy women. Children without ASD of mothers with any of the metabolic conditions displayed mild deficits in problem solving, language comprehension and production, motor skills and socialization.

"Over a third of U.S. women in their childbearing years are obese, and nearly one-tenth have gestational or type 2 diabetes during pregnancy. Our finding that these maternal conditions may be linked with neurodevelopmental problems in children raises concerns and therefore may have serious public-health implications," said a Krakowiak, a PhD Candidate in Epidemiology affiliated with the MIND Institute. "And while the study does not conclude that diabetes and obesity cause ASD and developmental delays, it suggests that fetal exposure to elevated glucose and maternal inflammation levels adversely affect fetal development."

The study, "Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders," is published online April 9 in Pediatrics, the Journal of the American Academy of Pediatrics. Its authors said that it is the first study to examine the associations between neurodevelopmental disorders and maternal metabolic conditions not restricted solely to type 2 or gestational diabetes. It is also the first to include obesity and hypertension, which have similar underlying biological characteristics, and to investigate correlations between these conditions and impairments in the skills and abilities of children in specific developmental domains.

Over 60 percent of U.S. women of childbearing age are overweight; 34 percent are obese; and 16 percent have metabolic syndrome. Nearly 9 percent of U.S. women of childbearing age are diabetic, and more than 1 percent of U.S. pregnancies were complicated by chronic hypertension. In California, where the study was conducted, 1.3 percent of women had type 2 diabetes, and 7.4 percent had gestational diabetes.

Autism spectrum disorder is characterized by impairments in social interaction, communication deficits and repetitive behaviors and often is accompanied by intellectual disability. An estimated 1 in 88 children born today will be diagnosed with autism spectrum disorder, according to statistics recently released by the U.S. Centers for Disease Control and Prevention. An estimated 1 in 83 U.S. children has another developmental disorder, which includes other disorders resulting in intellectual disability.

The study included 1,004 mother/child pairs from diverse backgrounds enrolled in the Childhood Autism Risks from Genetics and the Environment Study (CHARGE), most of them living in Northern California, with a small subset living in Los Angeles. The children were between 24 and 60 months old, born in California and resided with at least one biological parent who spoke either English or Spanish. There were 517 children who had ASD; 172 who had other developmental disorders but not ASD; and 315 who were developing typically. The participants were enrolled between January 2003 and June 2010.

The researchers obtained demographic and medical information for the mothers and their children using the CHARGE Study Environmental Exposure Questionnaire, a telephone survey, the study participants' birth files and medical records. The primary metabolic conditions of interest were type 2 diabetes or gestational diabetes.

Women were considered diabetic if the condition was noted in their medical records or if during the telephone surveys they answered "yes" to the questions "During this pregnancy were you ever told by a physician or nurse that you had gestational diabetes?" or "At any time before you became pregnant were you told by a doctor that you had [type 2] diabetes?" The same wording was used to obtain information about hypertension. BMI was calculated using height and weight prior to pregnancy from medical records or telephone interviews.

To confirm the developmental diagnoses of the children with ASD researchers used the Autism Diagnostic Interview-Revised (ADIR) and the Autism Diagnostic Observation Schedules (ADOS). All of the children were administered the Mullen Sales of Early Learning and the Vineland Adaptive Behavior Scales to assess their cognitive and adaptive development Spanish-speaking children were administered the tests in Spanish. The participants were then divided into groups of children with ASD, developmental delay or typical development.

Among children whose mothers were diabetic during their pregnancies, the study found that the percentage of children with ASD born to women with type 2 diabetes or gestational diabetes (9.3 percent) or developmental disability (11.6 percent) was higher than the 6.4 percent of children with ASD born to women without these metabolic conditions.

Over 20 percent of the mothers of children with ASD or developmental delay were obese, compared with 14 percent of the mothers of typically developing children.

Approximately 29 percent of the children with ASD had mothers with a metabolic condition, and nearly 35 percent of the children with developmental delay had mothers with metabolic conditions. In contrast, 19 percent of the typically developing children had mothers with a metabolic condition.

The study also examined the link between hypertension and ASD or developmental disorders. The prevalence of high blood pressure was low for all groups, but more than two times higher among mothers of children with ASD or developmental delay than among mothers of children with typical development, though the finding did not reach statistical significance.

Analyses of the children's cognitive abilities found that, among the children with ASD, children of mothers with diabetes exhibited poorer performance on tests of expressive and receptive language and communication skills of everyday living when compared with the children of healthy mothers. And the presence of any metabolic condition was associated with lower scores on all of the tests among children without ASD.

The authors note that obesity is a significant risk factor for diabetes and hypertension, and is characterized by increased insulin resistance and chronic inflammation, as are diabetes and hypertension. In diabetic, and possibility pre-diabetic pregnancies, poorly regulated maternal glucose can result in prolonged fetal exposure to elevated maternal glucose levels, which raises fetal insulin production, resulting in chronic fetal exposure to high levels of insulin.

Because elevated insulin production requires greater oxygen use this may result in depleted oxygen supply for the fetus. Diabetes also may result in fetal iron deficiency. Both conditions can adversely affect fetal brain development, the authors said.

"The sequence of events related to poorly regulated maternal glucose levels is one potential biological mechanism that may play a role in adverse fetal development in the presence of maternal metabolic conditions," Krakowiak said.

[Guest guest]

I also think it could be something to look at... I certainly was morbidly obese with my daughter, and my husband is diabetic.... Who knows what roles different issues in the parents may have played??? Anyway, I do also think that more research time needs to be put into finding better ways to help our children and ways to make it affordable.Carolyn W To: "Texas-Autism-Advocacy "

<Texas-Autism-Advocacy > Sent: Tuesday, April 10, 2012 11:45 AM Subject: Re: Maternal Obesity, Diabetes Associated With Autism

Alternatively, some value may come from this in the association of diabetes with autism in children. Diabetes is a metabolic disorder. There's a great deal of research related to metabolic/mitochondrial disorders/dysfunction and the link to autism. You can't move from association to causation with the study below (we hope) but it can still add value to the discussion.

Byrne

To: "Texas-Autism-Advocacy " <Texas-Autism-Advocacy > Sent: Tuesday, April 10, 2012 11:33 AMSubject: Re: Maternal Obesity, Diabetes Associated With Autism

Excellent input, . Let's concentrate on meaningful therapies to help those already diagnosed as well as trying to pinpoint the causes of Autism. However, most people in the mainstream will still think- overweight pregnant moms= higher chance of having a child with Autism based on the "results" of this study. Sent from my iPhone

I was interviewed regarding that yesterday. Here is the link: http://t.co/aGyPMynk

I'm right there with 'ya! I'm tired of hearing all of the things us mothers MAY have done to cause their child's Autism! My sister-in-law was morbidly obese & had gestational diabetes when pregnant with her twin girls who were also born 6 weeks early & both weighed under 4 lbs at birth- neither 1 has Autism. (They were born just a month before my son- who was born after a full-term pregnancy, I might add). Yet my seemingly "perfect" pregnancy produced a severely Autistic son 15 months after birth & a toddler who hit EVERY milestone early or on time until that point!? Reeks of "Refrigerator Mother" theory to me...

Sent from my iPhone



probably the same percentage was watching The Kardashians. should we assume that watching the Kardashians causes Autism.

I am sooooo sick and tired of these meaningless research and studies.

Remember few years ago..watching TV causes autism .....

btw: I weighed 140 pounds when I got pregnant with my son and I am 5 feet six inches tall.

Maternal Obesity, Diabetes Associated With Autism

Science News

.... from universities, journals, and other research organizations

Maternal Obesity, Diabetes Associated With Autism, Other Developmental Disorders

ScienceDaily (Apr. 9, 2012) — A major study conducted by researchers affiliated with the UC MIND Institute has found strong links between maternal diabetes and obesity and the likelihood of having a child with autism spectrum disorder (ASD) or another developmental disorder.

The study, which investigated the relationships between maternal metabolic conditions and the risk of neurodevelopmental disorders, found that mothers who were obese were 67 percent more likely to have a child with ASD than normal-weight mothers without diabetes or hypertension, and were more than twice as likely to have a child with another developmental disorder.

Mothers with diabetes were found to have nearly 67 percent more likely to have a child with developmental delays as healthy mothers. However, the proportion of mothers with diabetes who had a child with ASD was higher than in healthy moms but did not reach statistical significance.

The study also found that the children of diabetic mothers who had ASD were more disabled -- had greater deficits in language comprehension and production and adaptive communication -- than were the children with ASD born to healthy mothers.

However, even children without ASD born to diabetic mothers exhibited impairments in socialization in addition to language comprehension and production, when compared with the non-ASD children of healthy women. Children without ASD of mothers with any of the metabolic conditions displayed mild deficits in problem solving, language comprehension and production, motor skills and socialization.

"Over a third of U.S. women in their childbearing years are obese, and nearly one-tenth have gestational or type 2 diabetes during pregnancy. Our finding that these maternal conditions may be linked with neurodevelopmental problems in children raises concerns and therefore may have serious public-health implications," said a Krakowiak, a PhD Candidate in Epidemiology affiliated with the MIND Institute. "And while the study does not conclude that diabetes and obesity cause ASD and developmental delays, it suggests that fetal exposure to elevated glucose and maternal inflammation levels adversely affect fetal development."

The study, "Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders," is published online April 9 in Pediatrics, the Journal of the American Academy of Pediatrics. Its authors said that it is the first study to examine the associations between neurodevelopmental disorders and maternal metabolic conditions not restricted solely to type 2 or gestational diabetes. It is also the first to include obesity and hypertension, which have similar underlying biological characteristics, and to investigate correlations between these conditions and impairments in the skills and abilities of children in specific developmental domains.

Over 60 percent of U.S. women of childbearing age are overweight; 34 percent are obese; and 16 percent have metabolic syndrome. Nearly 9 percent of U.S. women of childbearing age are diabetic, and more than 1 percent of U.S. pregnancies were complicated by chronic hypertension. In California, where the study was conducted, 1.3 percent of women had type 2 diabetes, and 7.4 percent had gestational diabetes.

Autism spectrum disorder is characterized by impairments in social interaction, communication deficits and repetitive behaviors and often is accompanied by intellectual disability. An estimated 1 in 88 children born today will be diagnosed with autism spectrum disorder, according to statistics recently released by the U.S. Centers for Disease Control and Prevention. An estimated 1 in 83 U.S. children has another developmental disorder, which includes other disorders resulting in intellectual disability.

The study included 1,004 mother/child pairs from diverse backgrounds enrolled in the Childhood Autism Risks from Genetics and the Environment Study (CHARGE), most of them living in Northern California, with a small subset living in Los Angeles. The children were between 24 and 60 months old, born in California and resided with at least one biological parent who spoke either English or Spanish. There were 517 children who had ASD; 172 who had other developmental disorders but not ASD; and 315 who were developing typically. The participants were enrolled between January 2003 and June 2010.

The researchers obtained demographic and medical information for the mothers and their children using the CHARGE Study Environmental Exposure Questionnaire, a telephone survey, the study participants' birth files and medical records. The primary metabolic conditions of interest were type 2 diabetes or gestational diabetes.

Women were considered diabetic if the condition was noted in their medical records or if during the telephone surveys they answered "yes" to the questions "During this pregnancy were you ever told by a physician or nurse that you had gestational diabetes?" or "At any time before you became pregnant were you told by a doctor that you had [type 2] diabetes?" The same wording was used to obtain information about hypertension. BMI was calculated using height and weight prior to pregnancy from medical records or telephone interviews.

To confirm the developmental diagnoses of the children with ASD researchers used the Autism Diagnostic Interview-Revised (ADIR) and the Autism Diagnostic Observation Schedules (ADOS). All of the children were administered the Mullen Sales of Early Learning and the Vineland Adaptive Behavior Scales to assess their cognitive and adaptive development Spanish-speaking children were administered the tests in Spanish. The participants were then divided into groups of children with ASD, developmental delay or typical development.

Among children whose mothers were diabetic during their pregnancies, the study found that the percentage of children with ASD born to women with type 2 diabetes or gestational diabetes (9.3 percent) or developmental disability (11.6 percent) was higher than the 6.4 percent of children with ASD born to women without these metabolic conditions.

Over 20 percent of the mothers of children with ASD or developmental delay were obese, compared with 14 percent of the mothers of typically developing children.

Approximately 29 percent of the children with ASD had mothers with a metabolic condition, and nearly 35 percent of the children with developmental delay had mothers with metabolic conditions. In contrast, 19 percent of the typically developing children had mothers with a metabolic condition.

The study also examined the link between hypertension and ASD or developmental disorders. The prevalence of high blood pressure was low for all groups, but more than two times higher among mothers of children with ASD or developmental delay than among mothers of children with typical development, though the finding did not reach statistical significance.

Analyses of the children's cognitive abilities found that, among the children with ASD, children of mothers with diabetes exhibited poorer performance on tests of expressive and receptive language and communication skills of everyday living when compared with the children of healthy mothers. And the presence of any metabolic condition was associated with lower scores on all of the tests among children without ASD.

The authors note that obesity is a significant risk factor for diabetes and hypertension, and is characterized by increased insulin resistance and chronic inflammation, as are diabetes and hypertension. In diabetic, and possibility pre-diabetic pregnancies, poorly regulated maternal glucose can result in prolonged fetal exposure to elevated maternal glucose levels, which raises fetal insulin production, resulting in chronic fetal exposure to high levels of insulin.

Because elevated insulin production requires greater oxygen use this may result in depleted oxygen supply for the fetus. Diabetes also may result in fetal iron deficiency. Both conditions can adversely affect fetal brain development, the authors said.

"The sequence of events related to poorly regulated maternal glucose levels is one potential biological mechanism that may play a role in adverse fetal development in the presence of maternal metabolic conditions," Krakowiak said.

[Guest guest]

Due to time constraints my interview was SoundByted a lot. I did mention the same sort of stuff. I do think research is very important and said so before editing but I also think that we should also be doing as much as we can to help those that already have autism. It's a balance. :)Sent from my iPhone

I also think it could be something to look at... I certainly was morbidly obese with my daughter, and my husband is diabetic.... Who knows what roles different issues in the parents may have played??? Anyway, I do also think that more research time needs to be put into finding better ways to help our children and ways to make it affordable.Carolyn W To: "Texas-Autism-Advocacy "

<Texas-Autism-Advocacy > Sent: Tuesday, April 10, 2012 11:45 AM Subject: Re: Maternal Obesity, Diabetes Associated With Autism

Alternatively, some value may come from this in the association of diabetes with autism in children. Diabetes is a metabolic disorder. There's a great deal of research related to metabolic/mitochondrial disorders/dysfunction and the link to autism. You can't move from association to causation with the study below (we hope) but it can still add value to the discussion.

Byrne

To: "Texas-Autism-Advocacy " <Texas-Autism-Advocacy > Sent: Tuesday, April 10, 2012 11:33 AMSubject: Re: Maternal Obesity, Diabetes Associated With Autism

Excellent input, . Let's concentrate on meaningful therapies to help those already diagnosed as well as trying to pinpoint the causes of Autism. However, most people in the mainstream will still think- overweight pregnant moms= higher chance of having a child with Autism based on the "results" of this study. Sent from my iPhone

I was interviewed regarding that yesterday. Here is the link: http://t.co/aGyPMynk

I'm right there with 'ya! I'm tired of hearing all of the things us mothers MAY have done to cause their child's Autism! My sister-in-law was morbidly obese & had gestational diabetes when pregnant with her twin girls who were also born 6 weeks early & both weighed under 4 lbs at birth- neither 1 has Autism. (They were born just a month before my son- who was born after a full-term pregnancy, I might add). Yet my seemingly "perfect" pregnancy produced a severely Autistic son 15 months after birth & a toddler who hit EVERY milestone early or on time until that point!? Reeks of "Refrigerator Mother" theory to me...

Sent from my iPhone



probably the same percentage was watching The Kardashians. should we assume that watching the Kardashians causes Autism.

I am sooooo sick and tired of these meaningless research and studies.

Remember few years ago..watching TV causes autism .....

btw: I weighed 140 pounds when I got pregnant with my son and I am 5 feet six inches tall.

Maternal Obesity, Diabetes Associated With Autism

Science News

.... from universities, journals, and other research organizations

Maternal Obesity, Diabetes Associated With Autism, Other Developmental Disorders

ScienceDaily (Apr. 9, 2012) — A major study conducted by researchers affiliated with the UC MIND Institute has found strong links between maternal diabetes and obesity and the likelihood of having a child with autism spectrum disorder (ASD) or another developmental disorder.

The study, which investigated the relationships between maternal metabolic conditions and the risk of neurodevelopmental disorders, found that mothers who were obese were 67 percent more likely to have a child with ASD than normal-weight mothers without diabetes or hypertension, and were more than twice as likely to have a child with another developmental disorder.

Mothers with diabetes were found to have nearly 67 percent more likely to have a child with developmental delays as healthy mothers. However, the proportion of mothers with diabetes who had a child with ASD was higher than in healthy moms but did not reach statistical significance.

The study also found that the children of diabetic mothers who had ASD were more disabled -- had greater deficits in language comprehension and production and adaptive communication -- than were the children with ASD born to healthy mothers.

However, even children without ASD born to diabetic mothers exhibited impairments in socialization in addition to language comprehension and production, when compared with the non-ASD children of healthy women. Children without ASD of mothers with any of the metabolic conditions displayed mild deficits in problem solving, language comprehension and production, motor skills and socialization.

"Over a third of U.S. women in their childbearing years are obese, and nearly one-tenth have gestational or type 2 diabetes during pregnancy. Our finding that these maternal conditions may be linked with neurodevelopmental problems in children raises concerns and therefore may have serious public-health implications," said a Krakowiak, a PhD Candidate in Epidemiology affiliated with the MIND Institute. "And while the study does not conclude that diabetes and obesity cause ASD and developmental delays, it suggests that fetal exposure to elevated glucose and maternal inflammation levels adversely affect fetal development."

The study, "Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders," is published online April 9 in Pediatrics, the Journal of the American Academy of Pediatrics. Its authors said that it is the first study to examine the associations between neurodevelopmental disorders and maternal metabolic conditions not restricted solely to type 2 or gestational diabetes. It is also the first to include obesity and hypertension, which have similar underlying biological characteristics, and to investigate correlations between these conditions and impairments in the skills and abilities of children in specific developmental domains.

Over 60 percent of U.S. women of childbearing age are overweight; 34 percent are obese; and 16 percent have metabolic syndrome. Nearly 9 percent of U.S. women of childbearing age are diabetic, and more than 1 percent of U.S. pregnancies were complicated by chronic hypertension. In California, where the study was conducted, 1.3 percent of women had type 2 diabetes, and 7.4 percent had gestational diabetes.

Autism spectrum disorder is characterized by impairments in social interaction, communication deficits and repetitive behaviors and often is accompanied by intellectual disability. An estimated 1 in 88 children born today will be diagnosed with autism spectrum disorder, according to statistics recently released by the U.S. Centers for Disease Control and Prevention. An estimated 1 in 83 U.S. children has another developmental disorder, which includes other disorders resulting in intellectual disability.

The study included 1,004 mother/child pairs from diverse backgrounds enrolled in the Childhood Autism Risks from Genetics and the Environment Study (CHARGE), most of them living in Northern California, with a small subset living in Los Angeles. The children were between 24 and 60 months old, born in California and resided with at least one biological parent who spoke either English or Spanish. There were 517 children who had ASD; 172 who had other developmental disorders but not ASD; and 315 who were developing typically. The participants were enrolled between January 2003 and June 2010.

The researchers obtained demographic and medical information for the mothers and their children using the CHARGE Study Environmental Exposure Questionnaire, a telephone survey, the study participants' birth files and medical records. The primary metabolic conditions of interest were type 2 diabetes or gestational diabetes.

Women were considered diabetic if the condition was noted in their medical records or if during the telephone surveys they answered "yes" to the questions "During this pregnancy were you ever told by a physician or nurse that you had gestational diabetes?" or "At any time before you became pregnant were you told by a doctor that you had [type 2] diabetes?" The same wording was used to obtain information about hypertension. BMI was calculated using height and weight prior to pregnancy from medical records or telephone interviews.

To confirm the developmental diagnoses of the children with ASD researchers used the Autism Diagnostic Interview-Revised (ADIR) and the Autism Diagnostic Observation Schedules (ADOS). All of the children were administered the Mullen Sales of Early Learning and the Vineland Adaptiv

[Guest guest]

My fear is that as a result of this study, pregnant mothers will eat

more unhealthy diet foods, full of aspartame and MSG and other yucky stuff.

Love and prayers,

Heidi N