Potassium magnesium supplementation ...reduces blood pressure in ...essential hypertension

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Clin Exp Hypertens. 2006 Jul;28(5):489-97.

Potassium magnesium supplementation for four weeks improves small

distal artery compliance and reduces blood pressure in patients with

essential hypertension.

Wu G, Tian H, Han K, Xi Y, Yao Y, Ma A.

Cardiovascular Department, the First Hospital of Xi'an Jiaotong

University, Key Laboratory of Environment and Genes Related to Diseases,

Ministry of Education, Xi'an, Shaanxi, China.

It has been postulated that the loss of arterial compliance may

precede cardiovascular diseases, and that arterial compliance is an

important parameter to consider when evaluating arterial diseases such

as essential hypertension (EH) and the effects of antihypertensive

treatment. In all, 133 EH patients and 147 healthy subjects were

enrolled in this study. Large arterial compliance (C1) and small

arterial compliance (C2) were measured by the CVProfilortrade mark

DO-2020 CardioVascular Profiling System. Thirty-five patients randomly

received magnesium potassium supplementation (magnesium, 70.8 mg/d;

potassium, 217.2 mg/d) for four weeks, and 32 patients received

lacidipin (4mg/d) as a control. Before and after the four weeks, blood

pressure, C1, and C2 were measured. It was found that arterial

compliance was significantly lower in EH patients compared with healthy

subjects (C1: 12.53 +/- 0.33 vs. 15.63 +/- 0.30 ml/mmHg x 10, p <

0.01;C2: 3.79 +/- 0.17 vs. 5.69 +/- 0.25 ml/mmHg x 100,p < 0.01). On

lacidipine, systolic and diastolic BP decreased 13.27 +/- 1.76 mm Hg and

6.33 +/- 1.55 mm Hg, and C1 and C2 compliance values increased 25.05%

+/- 4.49% and 34.50% +/- 7.40%, respectively. On K+ and Mg2+

supplementation, systolic and diastolic BP decreased 7.83 +/- 1.87 mm Hg

and 3.67 +/- 1.03 mm Hg, and C1 and C2 compliance values increased

12.44% +/- 4.43% and 45.25% +/- 6.67%, respectively. Decreases in

systemic vascular resistance (mean arterial pressure divided by cardiac

output) by 11.9% and 16.6 % (p < 0.01) were seen between the

drug-induced changes, respectively. Both large arterial compliance and

small arterial compliance were decreased in essential hypertension

patients. In essential hypertension patients, magnesium and potassium

supplementation could improve small arterial compliance, while

lacidipine improved large arterial compliance significantly.

PMID: 16820345 [PubMed - in process]

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