Supplementation With Chromium-Enriched Yeast May Improve Blood Glucose ..... in Type 2 DM

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Supplementation With Chromium-Enriched Yeast May Improve Blood Glucose

Variables and Oxidative Stress in Type 2 Diabetics

Reference: “Influence of chromium-enriched yeast on blood glucose and

insulin variables, blood lipids, and markers of oxidative stress in

subjects with type 2 diabetes mellitus,” Racek J, Trefil L, et al, Biol

Trace Elem Res., 2006; 109(3): 215-30. (Address: Institute of Clinical

Biochemistry and Hematology, University, Medical Faculty in

Pilsen, Czech Republic).

Summary: In a randomized, placebo-controlled, double-blind study

involving 36 subjects (9 men, 27 women, mean age: 61.3 years old, mean

body mass index: 34.33 kg/m2) with type 2 diabetes mellitus (median

duration: 3 years), supplementation with chromium (Cr) enriched yeast

was found to improve blood glucose variables and oxidative stress. The

subjects were randomized to supplementation with 400 microg Cr/day as

Cr-enriched yeast (n=19) or placebo (n=17), for 12 weeks. A significant

increase in serum Cr and a significant decrease in fasting serum glucose

was observed in the Cr group, compared to the placebo group. At

intervention end, glutathione peroxidase activity and levels of reduced

glutathione were significantly decreased in the placebo group, while

remaining essentially unchanged in the Cr group. Additionally, while

serum glycated hemoglobin (HbA1c) and glycated protein were essentially

unchanged in the Cr group, HbA1c tended to increase in the placebo group

(from 6.94% to 7 .11%). Fasting serum insulin decreased with a greater

tendency in the Cr group compared to the placebo group (-16.5% vs.

-9.5%). Thus, this study suggests that in well-controlled type 2

diabetics, supplementation with Cr-enriched yeast may improve blood

glucose variables and oxidative stress.

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