Sucralose is absorbed per one study

[Guest guest]

So, why do the makers of Sucralose claim that it isn't absorbed, in light of

research like this? Can we believe it's 'safe' when some patients claim it

causes headaches and such?

Jan

Acta Physiol Scand. 2004 Oct;182(2):171-7. Related Articles, Links

 

Evaluation of a triple sugar test of colonic permeability in humans.

AD, Jain PK, Fleming S, Poon P, CJ, MacFie J.

Combined Gastroenterology Research Group, Scarborough Hospital, Scarborough,

UK.

AIM: Conventional dual sugar tests of intestinal permeability assess only the

stomach and small intestine. A novel triple sugar method of assessing colonic

permeability has recently been described in animals. This utilizes the

non-fermented sweetener sucralose, in addition to conventional sugars. It has

been

postulated that this test enables the simultaneous assessment of

small-intestinal and colonic barrier function in humans. The aim of this study

was to

evaluate the triple sugar test using healthy volunteers and ileostomists.

METHODS:

Twenty-one healthy volunteers and 18 ileostomists underwent the triple sugar

test. After an overnight fast, subjects drank a solution containing lactulose (5

g), rhamnose (1 g) and sucralose (5 g). Urine was collected for 0-5 h and

5-19 h. Urinary sugars were quantified using HPLC, and 5 and 24-h excretion

calculated. Nineteen control subjects and 16 ileostomists also underwent a

51Cr-EDTA permeability test. Permeability data were presented as medians (IQR),

and

differences between groups analysed with Mann-Whitney U-tests. RESULTS:

Lactulose excretion and the 5-h lactulose/rhamnose (L/R) ratio were similar in

controls and ileostomists [L/R ratio 0.024 (0.022-0.034) vs. 0.025

(0.022-0.035), P =

0.955]. Twenty-four hours excretion of sucralose was significantly higher in

control subjects compared with ileostomists [1.41% (1.17-1.68) vs. 0.96%

(0.64-1.2), P = 0.003]. The same pattern was seen with 51Cr-EDTA [2.73%

(2.06-3.76)

vs. 2.06% (1.55-2.71), P = 0.037] and with lactulose [0.52% (0.42-0.60) vs.

0.25% (0.16-0.35), P = 0.002]. CONCLUSIONS: Both sucralose and 51Cr-EDTA

underwent significant colonic absorption. A significant amount of lactulose also

appeared to be absorbed in the colon. This unexpected finding requires further

study. Copyright 2004 Scandinavian Physiological Society

Jan Patenaude, RD

Director, Medical Nutrition

Signet Diagnostic Corp.

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