Another Sucralose is absorbed abstract

[Guest guest]

Another:

Appears the claims that Sucralose is NOT absorbed are false. So, what is the

physiologic response to this food, long term?

Comments?

Food Chem Toxicol. 2000;38 Suppl 2:S31-41. Related Articles, Links

 

Sucralose metabolism and pharmacokinetics in man.

A, Renwick AG, Sims J, Snodin DJ.

University of Southampton, Bassett Crescent East, Southampton SO9 3TU, UK.

The metabolic and pharmacokinetic profile of sucralose was studied in human

volunteers. Following a single oral dose of (14)C-sucralose (1mg/kg, 100

microCi) to eight male subjects, a mean of 14.5% (range 8.9 to 21.8%) of the

radioactivity was excreted in urine and 78.3% (range 69.4 to 89.6%) in the

faeces,

within 5 days. The total recovery of radioactivity averaged 92.8%. Plasma

concentrations of radioactivity were maximal at about 2 hours after dosing. The

mean

residence time (MRT) for sucralose was 18.8hr, while the effective half-life

for the decline of plasma radioactivity was 13hr. Two volunteers given a

higher oral dose (10mg/kg, 22.7 microCi) excreted a mean of 11.2% (9.6 and

12.7%)

of the radioactivity in urine, and 85.5% (84.1 and 86.8%) in faeces over 5

days. The total recovery of radioactivity was 96.7%. The radiolabelled material

present in faeces was essentially unchanged sucralose. Sucralose was the

principal component in the urine together with two more polar components which

accounted for only 2.6% of the administered dose (range 1.5 to 5.1% of dose);

both

metabolites possessed characteristics of glucuronide conjugates of sucralose.

Jan Patenaude, RD

Director, Medical Nutrition

Signet Diagnostic Corp.

www.nowleap.com

1- (toll free)

Fax:

DineRight4@... or JanP@...

Disease Management Programs for Irritable Bowel Syndrome and Migraine caused

by Food Sensitivity

IMPORTANT - This e-mail message is intended only for the use of the

individual or entity to which it is addressed, and may contain information that

is

privileged, confidential and exempt from disclosure under applicable law. If you

have received this message in error, you are hereby notified that we do not

consent to any reading, dissemination, distribution or copying of this e-mail

message. If you have received this communication in error, please notify the

sender immediately by e-mail and telephone ( toll free) and destroy

the transmitted information.

E-mail transmission cannot be guaranteed to be secure or error-free as

information could be intercepted, corrupted, lost, destroyed, arrive late,

incomplete, or contain viruses. The sender therefore does not accept liability

for any

errors or omissions in the contents of this message, which arise as a result

of e-mail transmission.