Guest guest Posted September 18, 2004 Report Share Posted September 18, 2004 Oh, for God's sake. WHAT THE HELL IS THIS STUFF???? Yeah, yeah, I know, it's a short-acting benzo! But If they didn't use Versed, what WOULD they use for anesthetic? I'd never have this drug again if I ever had to have surgery. UGH! All this stuff makes me glad I survived the surgery. You poor ladies having to have a surgery. I'd be a basket case. No, wait, I AM a basket case. LOL "Blind Reason" a novel of pharmaceutical intrigue Think your antidepressant is safe? Think again. It's Unsafe At Any Dose Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 18, 2004 Report Share Posted September 18, 2004 how is this different/more dangerous than the general anesthesia? susan Versed Black Box Warning WARNING Adults and Pediatrics: Intravenous VERSED has been associated with respiratory depression and respiratory arrest, especially when used for sedation in noncritical care settings. In some cases, where this was not recognized promptly and treated effectively, death or hypoxic encephalopathy has resulted. Intravenous VERSED should be used only in hospital or ambulatory care settings, including physicians' and dental offices, that provide for continuous monitoring of respiratory and cardiac function, ie, pulse oximetry. Immediate availability of resuscitative drugs and age- and size-appropriate equipment for bag/valve/mask ventilation and intubation, and personnel trained in their use and skilled in airway management should be assured (see WARNINGS ). For deeply sedated pediatric patients, a dedicated individual, other than the practitioner performing the procedure, should monitor the patient throughout the procedure. The initial intravenous dose for sedation in adult patients may be as little as 1 mg, but should not exceed 2.5 mg in a normal healthy adult. Lower doses are necessary for older (over 60 years) or debilitated patients and in patients receiving concomitant narcotics or other central nervous system (CNS) depressants. The initial dose and all subsequent doses should always be titrated slowly; administer over at least 2 minutes and allow an additional 2 or more minutes to fully evaluate the sedative effect. The use of the 1 mg/mL formulation or dilution of the 1 mg/mL or 5 mg/mL formulation is recommended to facilitate slower injection. Doses of sedative medications in pediatric patients must be calculated on a mg/kg basis, and initial doses and all subsequent doses should always be titrated slowly. The initial pediatric dose of VERSED for sedation/anxiolysis/amnesia is age, procedure, and route dependent (see DOSAGE AND ADMINISTRATION for complete dosing information). Neonates: VERSED should not be administered by rapid injection in the neonatal population. Severe hypotension and seizures have been reported following rapid IV administration, particularly with concomitant use of fentanyl (see DOSAGE AND ADMINISTRATION for complete information). ========================================================= CLINICAL PHARMACOLOGY VERSED is a short-acting benzodiazepine central nervous system (CNS) depressant. The effects of VERSED on the CNS are dependent on the dose administered, the route of administration, and the presence or absence of other medications. Onset time of sedative effects after IM administration in adults is 15 minutes, with peak sedation occurring 30 to 60 minutes following injection. In one adult study, when tested the following day, 73% of the patients who received VERSED intramuscularly had no recall of memory cards shown 30 minutes following drug administration; 40% had no recall of the memory cards shown 60 minutes following drug administration. Onset time of sedative effects in the pediatric population begins within 5 minutes and peaks at 15 to 30 minutes depending upon the dose administered. In pediatric patients, up to 85% had no recall of pictures shown after receiving intramuscular VERSED compared with 5% of the placebo controls. Sedation in adult and pediatric patients is achieved within 3 to 5 minutes after intravenous (IV) injection; the time of onset is affected by total dose administered and the concurrent administration of narcotic premedication. Seventy-one percent of the adult patients in endoscopy studies had no recall of introduction of the endoscope; 82% of the patients had no recall of withdrawal of the endoscope. In one study of pediatric patients undergoing lumbar puncture or bone marrow aspiration, 88% of patients had impaired recall vs 9% of the placebo controls. In another pediatric oncology study, 91% of VERSED treated patients were amnestic compared with 35% of patients who had received fentanyl alone. When VERSED is given IV as an anesthetic induction agent, induction of anesthesia occurs in approximately 1.5 minutes when narcotic premedication has been administered and in 2 to 2.5 minutes without narcotic premedication or other sedative premedication. Some impairment in a test of memory was noted in 90% of the patients studied. A dose response study of pediatric patients premedicated with 1.0 mg/kg intramuscular (IM) meperidine found that only 4 out of 6 pediatric patients who received 600 µg/kg IV VERSED lost consciousness, with eye closing at 108 ± 140 seconds. This group was compared with pediatric patients who were given thiopental 5 mg/kg IV; 6 out of 6 closed their eyes at 20 ± 3.2 seconds. VERSED did not dependably induce anesthesia at this dose despite concomitant opioid administration in pediatric patients. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 18, 2004 Report Share Posted September 18, 2004 Guess I need to get a good old bottle of wiskey and chomp down on a big bullet like in the wild west !!!!!!!!!!! LOL .Ro Re: Versed Oh, for God's sake. WHAT THE HELL IS THIS STUFF???? Yeah, yeah, I know, it's a short-acting benzo! But If they didn't use Versed, what WOULD they use for anesthetic? I'd never have this drug again if I ever had to have surgery. UGH! All this stuff makes me glad I survived the surgery. You poor ladies having to have a surgery. I'd be a basket case. No, wait, I AM a basket case. LOL "Blind Reason" a novel of pharmaceutical intrigueThink your antidepressant is safe? Think again. It'sUnsafe At Any DoseTo subscribe to the off-topic list go to: http://groups.yahoo.com/group/socialWandR/ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 18, 2004 Report Share Posted September 18, 2004 <<how is this different/more dangerous than the general anesthesia? >> ** You didn't name what kind of general anesthesia. C Quote Link to comment Share on other sites More sharing options...
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