Guest guest Posted September 5, 2003 Report Share Posted September 5, 2003 >I was told I need a " solubilizer " to incorporate my ascorbyl >palmitate (which is oil soluable) into a water-based product. > >I was told that " you can look at polysorbates from Uniqema, the >Tritons from Dow or the Igepals from Rhodia.Many people use Tween 20, >Tween 60 or Tween 80 from Uniqema. (www.uniqema.com) Look at Triton >100 osolubilizers include most high HLB nonionic surfactants and SLS. >Among those are Triton 102 from Dow. (www.dowchemical.com) Igepal >CO630 and CO720 are also good. (www.rhodia.com). " > >Yikes!!!!! This is all greek to me! Can anyone translate this into >English for me, and suggest what I might use? I think you would be better off trying to emulsify Ascorbyl Palmitate versus solubilizing it. The required HLB for Ascorbyl Palmitate is ~ 6. When you solubilize an oil, you are making a microemulsion. from the CosmeticInfo message archives: >Stability of ascorbyl palmitate in topical microemulsions. > >Spiclin P, Gasperlin M, Kmetec V. > >Int J Pharm. 2001 Jul 17;222(2):271-9. > >Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000, >Ljubljana, Slovenia. > >Ascorbyl palmitate and sodium ascorbyl phosphate are derivatives of >ascorbic acid, which differ in stability and hydro-lipophilic >properties. They are widely used in cosmetic and pharmaceutical >preparations. In the present work the stability of both derivatives was >studied in microemulsions for topical use as carrier systems. The >microemulsions were of both o/w and w/o types and composed of the same >ingredients. The stability of the less stable derivative ascorbyl >palmitate was tested under different conditions to evaluate the >influence of initial concentration, location in microemulsion, >dissolved oxygen and storage conditions. High concentrations of >ascorbyl palmitate reduced the extent of its degradation. The location >of ascorbyl palmitate in the microemulsion and oxygen dissolved in the >system together significantly influence the stability of the compound. >Light accelerated the degradation of ascorbyl palmitate. In contrast, >sodium ascorbyl phosphate was stable in both types of microemulsions. >Sodium ascorbyl phosphate is shown to be convenient as an active >ingredient in topical preparations. In the case of ascorbyl palmitate, >long-term stability in selected microemulsions was not adequate. To >formulate an optimal carrier system for this ingredient other factors >influencing the stability have to be considered. Maurice -------------------------------------------------------- Maurice O. Hevey Convergent Cosmetics, Inc. http://www.ConvergentCosmetics.com ------------------------------------------------------- Quote Link to comment Share on other sites More sharing options...
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