lactic acid

[Guest guest]

ne

I have basically no personnal experience with Lactobacillus.

The article below from www.vrp.com probably contains nothing

new to you. I don't know. I would also suggest:

http://www.lef.org

type " lactic acid " in quotes at the search box.

A number of articles will come up.

Szpak

Lactobacillus GG:

New Breakthrough Probiotic Clinically

Proven to Support Gastrointestinal Health

by Jim English and Ward Dean, M.D.

Over the past several years the relationship of the health of the

intestinal tract to the overall health of the body has become

increasingly appreciated. The human gastrointestinal (GI) tract is

home to a vast and complex bacterial ecosystem, hosting over 400

different species.1,2 The GI tract in a healthy adult is about 30

feet long and contains anywhere from 5 to 15 pounds of living

bacteria. In healthy individuals the most common of these organisms

includes Escherichia coli, Klebsiella, Streptococcus, Lactobacillus,

Staphylococcus, Bacillus, Bifidobacterium, Fusobacterium,

Clostridium, Eubacterium Peptococcus, and Peptostreptoccus. In terms

of sheer numbers, the human intestinal tract contains ten times as

many bacterial cells as there are tissue cells in the entire body.

These gut microflora play a vital role in human health and perform

important metabolic functions that support the digestive system.

Research reveals that the gut lining is primarily nourished by

nutrients produced from favorable bacteria—not by our blood supply,

as was previously believed. We are completely reliant upon the

activities of these bacteria for the manufacture of key vitamins, the

assimilation and distribution of nutrients, and for the suppression

of pathogenic and putrefactive bacteria.

For example, bacterial fermentation, a vital component of our

digestive process, produces essential nutrients. Beneficial bacteria

are also the primary source of short chain fatty acids. Without

bacteria to produce these nutrients, cell damage can also occur,

leading to a loss of function in the gut lining. Consequently,

maintenance of the proper balance of bacteria in the gut is vital to

good health.

A Delicate Balance

Factors that can upset the delicate balance of the GI tract include:

Overgrowth of undesirable bacteria

Overgrowth of yeast, including candida

Parasites, such as amoebas

Viral illnesses, such as measles

Bad water or poor hygiene

Too many sweets or starchy foods

Too many alcoholic beverages

Food allergies

Certain medical drugs

Frequent use of antibiotics

Exposure to radiation

Surgical complications

Physical injury

Excessive stress

Environmental toxins

Genetic sensitivities to any of the above

The Gut Mucosal Barrier

Gut microflora play an important role in the intestine's defense

barrier. In the absence of a healthy intestinal microflora, antigen

transport is increased, leading to allergies and increased allergic

sensitivity.3

Most antigens in the diet are excluded from the body by a well-

functioning intestinal mucosal barrier.4 However, a fraction of these

can bypass this barrier in even the healthiest of people. The

antigens are absorbed across the epithelial layer by a process called

transcytosis. Transcytosis operates along two pathways 4,5 The main,

or degradative, pathway involves lysosomal processing of the proteins

into smaller peptide fragments. This reduces the immunogenicity of

the proteins, thereby diminishing the antigen load. This is important

in maintaining the host-defense system. Another pathway (paracellular

leakage) allows for the transport of intact proteins, a process that

can result in antigen-specific immune responses.

Paracellular leakage of macromolecules does not occur in a healthy

gastrointestinal tract because of intact, tight intracellular

junctions which maintain the macromolecular barrier. Consequently, in

healthy people, antigen transfer is well-controlled, and aberrant

antigen absorption does not occur.

Leaky Gut Syndrome

A large body of literature now describes the phenomenon known

as " leaky gut, " a syndrome characterized by abnormal permeability of

the intestines to potentially toxic or antigenic materials.

Inflammatory bowel disease, alcoholism, rheumatic conditions

involving the gut, allergic disorders, and a variety of other

problems appear to be associated with abnormal gut permeability.

Bacterial Translocation

A phenomenon related to leaky gut syndrome is that of bacterial

translocation, whereby whole bacteria or bacterial poisons

(endotoxins) pass through the gastrointestinal walls and are absorbed

by the lymph glands, liver, lungs and other organs. This bacterial

translocation and the associated absorption of endotoxins can result

in multiple organ stress and dysfunction.

A variety of natural substances have been shown in experimental and

clinical studies to enhance the protective and barrier functions of

the gut walls, and hence to diminish hyperpermeability and bacterial

translocation.

Functional Foods and Probiotics

A functional food is defined as a specialized food product that can

promote human health and well-being better than a similar traditional

food. The most widely used and recognized functional food is yogurt,

a product made by fermenting milk with bacteria. Prior to the

discovery of specific microbial pathogens, scientists recognized that

the intestinal flora could be improved by the ingestion of yogurt.

For centuries, medical practitioners counted on fermented dairy

products to ease various intestinal disorders—especially diarrhea.

The newest, and perhaps the most important group of foods in the

category of functional foods are the probiotics. Probiotic is a Greek

word which means " for life. " It is used to describe the " friendly "

bacteria that normally live in the intestinal tract and which

contribute to good health. Unfortunately, probiotics can be destroyed

or depleted by stress, aging, antibiotics, changes in one's diet, or

ingestion of foreign bacteria (often contracted while traveling in

foreign countries). Probiotics is also a label for food products that

contain health-promoting bacteria—primarily lactic-acid bacteria

(LAB) that have a positive influence on the metabolic activity of the

intestinal flora.

At the turn of the century, the Russian researcher, Dr. Élie

Metchnikoff suggested that the aging process could be mitigated by

altering the intestinal flora through the consumption of

lactobacillus-rich yogurt. In 1905, Metchnikoff conducted original

research that led to our first knowledge of Lactobacillus strains.

Metchnikoff introduced Lactobacillus bulgaricus (L. bulgaricus) into

the production of fermented milk. Consequently L. bulgaricus became

the standard starter strain, along with Streptococcus thermophilus,

for yogurt throughout the world (Metchnikoff E. The Prolongation of

Life: Optimistic Studies. New York: G.P. Putnam's Sons 1908).

While Metchnikoff's discovery aided in the treatment of many

intestinal disorders, the two strains of bacteria that he used did

not provide the degree of benefit he had hypothesized, partially due

to the inability of these strains to colonize the human intestinal

tract. These strains are sensitive to acid conditions, and are easily

destroyed in the stomach. Additionally, these bacterial species do

not normally inhabit the human gut.

Lactobacillus GG: Unique " Native " Bacterium in Human GI Tract

Lactobacilli constitute a major part of the microflora throughout the

gastrointestinal tract. These bacteria have been proposed as

candidate probiotic microorganisms to reinforce the barrier effect in

the gut. Consumption of probiotic bacteria can alleviate intestinal

inflammation, normalize increased intestinal permeability, and

strengthen the intestine's immunologic barrier function.6,7 The most

exciting of these materials is a new breakthrough probiotic

supplement, Culturelle™, (Lactobacillus GG).

Lactobacillus GG (Lactobacillus G.G., strain ATCC 53103) is a

bacterium that occurs naturally in the human digestive tract. This

strain of bacteria was first isolated by two Boston scientists,

Professors Sherwood Gorbach and Barry Goldin, who were searching for

a strain of lactobacillus that could colonize the human intestine and

thereby exert the beneficial effects which Metchnikoff had hoped to

produce by his yogurt cultures. As guides for their research, Gorbach

and Goldin established a number of criteria which they believed their

ideal probiotic candidate should satisfy. The bacterium would be: 1)

be of human origin; 2) capable of attaching to human intestinal

(epithelial) cells and colonizing the gut to prevent competition from

invading pathogens; 3) resistant to acid and bile, able to survive

transit from the stomach to the intestines; 4) exhibit beneficial,

health-promoting activity in the host system; and 5) exhibit a high

degree of safety.

In 1985, Gorbach and Goldin isolated their ideal probiotic " bug, "

which was designated, appropriately, Lactobacillus GG (LGG). Today,

LGG is the best-studied and most extensively documented probiotic

lactic-acid bacteria strain in the world. This strain stabilizes

human intestinal microflora and hastens the removal of pathogenic

microorganisms. Its beneficial effects in treating gastrointestinal

disorders and bacterial and viral infections are extremely well

documented, as is its ability to strengthen the immune system. In

addition to ongoing studies of LGG's ability to prevent

gastrointestinal infections, some interesting preliminary

observations on the antitumor effect of LGG in the colon have also

been reported. In Japan, a dairy product containing LGG is the first—

and only—food specified for probiotic use.

Treatment of Acute Diarrhea

Lactobacillus GG (LGG) has shown promising results in treating

diarrhea caused by viruses and bacteria in both adults and children.

Measurements of the intestinal microflora show that LGG adheres to

the intestinal wall during healthy periods as well as during episodes

of diarrhea. In addition, LGG improves microflora balance, and

normalizes fecal enzyme and short-chain fatty acid levels.

Safety of LGG

The safety assessment of Lactobacillus GG covers traditional toxicity

tests and studies on the safety of the GG strain in both in vivo and

in vitro conditions. A number of studies in different clinical

conditions, including human volunteer studies and epidemiologic

surveillance indicate that the strain is safe for human consumption,

even in large amounts. At present, Lactobacillus GG has the most

extensive safety assessment record of any other probiotic strain.

In Vitro Studies

The local effects of lactic-acid bacteria on the intestine are

commonly measured by their in vitro ability to adhere to human

intestinal cell walls and to degrade protective intestinal mucus.

These tests provide an indirect measure of the potential of lactic-

acid bacteria to invade intestinal cells and to damage the protective

glycoproteins of the intestinal mucus. A large number of studies have

been conducted with different strains of lactic-acid bacteria.

Lactobacillus GG showed no invasive properties, even though the

strain is strongly adherent to human intestinal cell lines. 10

Probiotic strains that do not degrade intestinal mucus or its

glycoproteins are likely to be noninvasive and beneficial to the

intestinal epithelium. In a recent study, commercial probiotic

strains—including Lactobacillus GG—were shown to be inactive in

mucosal degradation injury. In earlier studies, some fecal

Bifidobacteria were found to degrade mucus.8

Production of antimicrobial compounds and inhibition of pathogen

growth by lactic-acid bacteria has been assessed in vitro. Data from

these tests support the safety of Lactobacillus GG and indicate that

the strain decreases intestinal pH and reduces the numbers of

pathogenic bacteria in the intestinal tract thus protecting the

host.9,10

In the most recent safety-related study, Lactobacillus GG was

observed to slow down the development of dimethyl hydrazine-induced

colon tumors in rats on a high-fat diet.11 Similarly, Lactobacillus

GG decreased alcohol toxicity in mice, dramatically reducing plasma

endotoxin levels.12

Clinical Studies

Data from clinical trials in human volunteers also attest to the

safety of Lactobacillus GG. These studies included: short-term trials

in over 2,000 healthy normal volunteers; studies to determine the

efficacy of LGG in preventing and treating acute diarrhea in

premature infants,l3 infants,l4,15 and children with

diarrhea;12,l3,16 studies on immune effects;16 and studies in

patients with severe intestinal infections.8

A summary from the literature of safety studies and reported effects

indicate that no harmful effects have been observed in controlled

clinical studies with Lactobacillus GG. To the contrary, during

treatment of intestinal infections, beneficial effects have been

observed, including stabilization of the gut mucosal barrier,

prevention of diarrhea, and amelioration of infant and antibiotic-

associated diarrhea and intestinal inflammation.

A study from Peru indicates the ability of LGG to colonize the

intestinal tract of children. In this study, LGG was administered in

a lyophilized form which was sprinkled on Jello.17 LGG was recovered

from the stools of eight of 11 children, and in six cases it was

recovered on multiple occasions.

Childhood Diarrhea

Childhood diarrhea is a common disorder around the world, in both

developed and developing countries. The incidence of childhood

diarrhea varies from two to three episodes per year in economically

advanced countries, to twice that number in developing countries. In

the developing countries, childhood diarrhea is usually associated

with acute weight loss and high mortality. Effective treatment of

diarrhea with LGG has been reported in two studies from developing

countries (Pakistan and Thailand), and in one each from a Baltic

country (Estonia) and a European country (Italy).

LGG and Antibiotic Associated Diarrhea

Many antibiotics produce serious gastrointestinal side effects.

Erythromycin, especially, is a frequent cause of such problems. In a

study by Siitonen et al.,15,18 two groups of healthy volunteers took

a moderate dose of erythromycin—400 mg, three times daily for 7 days.

One group received LGG-containing yogurt, while the control group was

given conventional pasteurized yogurt. The number of daily bowel

movements was fewer, the duration of diarrhea was shorter, and the

frequency of stomach pain, abdominal pain, and nausea were

significantly reduced in the LGG group. Fecal counts of LGG during

erythromycin administration revealed that 75% of the volunteers had

detectable levels of LGG despite the use of an antibiotic that is

active against LGG in vitro.

Several investigations are currently being conducted on childhood

diarrhea in Europe and developing countries. The results that have

been published thus far provide convincing evidence that LGG is

beneficial in reducing the time-course and the symptoms of acute

diarrhea in children.

Conclusion

LGG continues to be extensively researched around the world, with

many more treatment and prevention trials currently underway. Thus,

more data will be forthcoming in the near future. Rather than wait

for the final conclusive results to be reported, we believe that

adequate studies have been performed to indicate that LGG is a safe,

highly effective nutritional substance for a wide variety of clinical

conditions, to include intestinal disorders—especially a number of

forms of diarrhea, including rotavirus diarrhea in children,

bacterial diarrhea in children and adults, travelers' diarrhea,

antibiotic-associated diarrhea, and C. difficile relapsing diarrhea

and colitis in children and adults. Measurements of the intestinal

microflora show intestinal implantation of LGG during healthy periods

and during diarrhea episodes, as well as improvements in microflora

balance and of flora function.

References

1. Finegold SM, Attebery HR, Sutter VL. Effect of diet on human fecal

flora: Comparison of Japanese and American Diets. Am J Clin Nutr

1974;27:1546-69

2. WEC, Holderman LV. Human fecal flora: Comparison of Japanese

and American diets. Appl Microbiol 1974;27:961-79.

3. Heyman M, Gorthier G, Petit A, Meslin J-C, Moreau C, Desjeux J-F.

Intestinal absorption of macromolecules during viral enteritis: An

experimental study on rotavirus-infected conventional and germ-free

mice. Pediatr Res 19887; 22:72-8.

4. Heyman M, Grasset E, Duroc R, Desjeux JF. Antigen absorption by

the jejunal epithelium of children with cow's milk allergy. Pediatr

Res 1988;24:197-202

5. Majamaa H, Isolauri E. Evaluation of gut mucosal barrier: Evidence

for increased antigen transfer in children with atopic eczema. J

Allergy Clin Immunol 1996;97:985-90.

6. Kaila M, Isolauri E, Soppi E, Virtanen E, Laine S, Arvilommi H.

Enhancement of the circulating antibody secreting cell response in

human diarrhea by a human Lactobacillus strain. Pediatr Res

1992;32:141-4.

7. Isolauri E, Majamaa H, Arvola T, Rantala I, Virtantn E, Arvilommi

H. Lactobacillus casei strain GG reverses increased intestinal

permeability induced by cow milk in suckling rats. Gastroenterology

1993;105:1643-50.

8. Hoskins LC, Augustines M, McKee WB, Boulding ET, Kriaris M,

Niedermeyer G. Mucin degradation in human colon ecosystems: Isolation

and properties of fecal strains that degrade ABH blood group antigens

and oligosaccharides from mucin glycoproteins. J Clin Invest

1985;75:977-53.

9. Coconnier MH, Klaenhammer TR, Kerneis S, Bernet MF, Servin A.

Protein-mediated adhesion of Lactobacillus acidophilus BG2F04 on

human enterocyte and mucus-secreting cell lines in culture. Appl

Environ Microbiol 1992;58:2034-9.

10. Elo S, Saxelin M, Salminen S. Attachment of Lactobacillus casei

strain GG to human colon carcinoma cell line Caco-2: Comparison with

other dairy strains. Lett Appl Microbiol 1991;13:154-6

11. Goldin B, Gualtieri L, R. The effect of feeding

Lactobacillus GG on the initiation and promotion of dimethylhydrazine-

induced intestinal tumors in the rat. Nutr Cancer 1996;25:197-204.

12. Namji AA, Khettry U, Sadrzadeh S. Lactobacillus feeding reduces

endotoxemia and severity of experimental alcoholic liver disease.

Proc Soc Exp Biol Med 1994;205:243-7.

13. Millar MR, Bacon C, SL, V, Hall MA. Enteral feeding

of premature infants with Lactobacillus GG. Arch Dis Child

1993;69:483-7

14. Seep E, Mikelsaar M, Salminen S. Effect of administration of

Lactobacillus casei strain GG on the gastrointestinal microbiota of

newborns. Microbial Ecol Health Dis 1993;6:309-14.

15. Majamaa H, Isolauri E, Saxelin M, Vesikari T. Lactic acid

bacteria in the treatment of acute rotavirus gastroenteritis. J

Pediatr Gastroenterol Nutr 1995;20:333-8.

16. Isolauri E, Juntunen M, Rautanen T, Sillanaukee P, Koivula T. A

human Lactobacillus strain (Lactobacillus casei sp strain GG)

promotes recovery from acute diarrhea in children. Pediatrics

1991;88:90-7.

17. Sheen P, Oberhelman RA, Gilman RH, Cabrera L, Versategui M,

Madico G. Short report: a placebo-controlled study of Lactobacillus

GG colonization in one- to three-year-old Peruvian children. Am J

Trop Med Hyg 1995;52-389-92.

18. Biller JA, Katz AJ, AF, Buie TM, Gorbach SL. Treatment of

recurrent Clostridium difficile colitis with Lactobacillus GG. J

Pediatr Gastroenterol Nutr 1995;21:224-6.

Related Products: (Click on links below to view product(s))

9601-BioPRO, 120cap

9600-BioPRO, pwdr 150gm

9182-Culturelle, Lactobacillus GG (LGG), 30 cap

6241-Digestive Enzymes, 180 cap

[Guest guest]

,

Thanks for the links. I guess my point is that everybody should be taking

lacto fermented food products, not just people with ms. I am not sure who

would not benefit from taking them and in fact they are necessary for normal

gastric function. A lot of people with ms have leaky gut and most of the

immune cells in our body are concentrated around the digestive tract. If

follows then that if people do not have good gut function and are letting in

stray food particles and the immune system is sent to attack them, that an

ms attack will happen. The first thing a person should ensure is that they

don't have leaky gut and one of the ways is with good bacteria. The

question is what is the best form to get the bacteria? I think I will stick

with rejuvelac for now and I have started eating a veggie kraut with every

meal.

ne

lactic acid

ne

Two links to information about lactic acid

are below. I haven't taken Lactobacillus or

associated bacteria in any earnest way. Perhaps

you can get something out of all this. (without

becoming too graphic, if a individual has bad

smelling gas, and then starts taking Lactobacillus

and has no improvment, I'd say it is probably a

bad idea, or at least a bad product.)

http://www.vrp.com/art/568.asp?c=1087423970796 & e= " lactic%

20acid " & f= " LACTIC%20ACID " & g= " lactic%

20acid " & k=/golibs.asp & m=/includes/vrpwebstyle.css & s=0

AND

http://search.lef.org/src-cgi-bin/MsmFind.exe?QUERY_ENCODING=UTF-

8 & CFGNAME=MssFind.cfg & ALLCATS=X & NO_DL=X & CAT_KEY= & AGE_WGT=0 & QUERY= " lact

ic%20acid "

Szpak

[Guest guest]

ne

You sound like you know a lot about all this already. In

other words I can't help.

I corresponded with someone named Carol Walton. She took

the Sputnik pill to kill parasties. It did so, unfortunately

her MS hasen't improved. There must be something else going

on here. If someone's digestion was absolutely perfect and

they had NO parasites, one wonders if the MS symptoms HAVE

to decrease. Or is that merely a hope? It goes without saying

that you have tried enzymes and herbs to improve your

digestion. Do you feel that supplemental enzymes should be

rotated? That is X days on and X days off?

Szpak

> ,

> Thanks for the links. I guess my point is that everybody should be

taking

> lacto fermented food products, not just people with ms. I am not

sure who

> would not benefit from taking them and in fact they are necessary

for normal

> gastric function. A lot of people with ms have leaky gut and most

of the

> immune cells in our body are concentrated around the digestive

tract. If

> follows then that if people do not have good gut function and are

letting in

> stray food particles and the immune system is sent to attack them,

that an

> ms attack will happen. The first thing a person should ensure is

that they

> don't have leaky gut and one of the ways is with good bacteria. The

> question is what is the best form to get the bacteria? I think I

will stick

> with rejuvelac for now and I have started eating a veggie kraut

with every

> meal.

> ne

>

> lactic acid

>

>

[Guest guest]

,

responses below

RE: Re: lactic acid

>>>>>>>>>>>>>>

This seems contradictory. Usually when you have low HCL, food stays in

your stomach too long and you get heartburn. Hunger though is a factor

of nourishment received from food. For example, eating candy stops

hunger for a while but it goes away quickly.

>>>>>>>>>>>

As I understand it, people who get heartburn are those whose valves don't

close all the way so some of the acid goes up instead of staying in the

stomach. Being hungry after meals is a classic symptom of not enough

hydrochloric acid; that and big bellies. My dad is like that; he has a

really big belly and does the same thing; eating right after a meal. If a

person drinks coke and they get relief from stomach problems, then they are

also low of hydrochloric acid. I guess this was the biggest Aha that I got

from reading about lactic acid; low stomach acidity is fairly common and

pretty much everybody needs help with digesting their food and lactic acid

does this. Traditional peoples ate a fermented food product or drank

fermented drinks with every meal.

>>>>>>>>>>>>>>>>>>

What kind of massage therapy was she doing? My wife says she cannot

tolerate any massage because of the pain of rubbing the muscles.

>>>>>>>>>>>>>>>>>>

Sorry I don't know what kind of massage she had but the other major symptom

she had was pain. And she said in the video she still has some pain but not

like before. She also had an energy advisor, somebody who understood

chakras and they would determine where the blocks were in her body and the

massage therapist would work in that area.

ne