MRK 518 + TMC 125 for salvage

[Guest guest]

Someone asked if these two products can now be used together via the respective

expanded access programs. The answer is no. Merck is still performing

interaction studies to see if these two drugs can be combined without dose

adjustment. They will let me know when that data are available.

Most people can use MRK 518 with either Fuzeon, Prezista, or Aptivus, plus a

background of nucleosides like Combivir, Truvada, or Epzicom. Non nukes like

Viramune and Sustiva may also be used.

Merck will be presenting their treatment experience data from their phase II

this Friday at ICAAC (I am in San Francisco now at that conference). I am sure

Jules will be sending out that info as soon as it is presented. It looks

extremely good with a large proportion of salvage patients achieving

undetectable viral loads, even without an active drug in their background.

Regards,

Vergel

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