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Luke,If I thought these drugs would quickly and safely reverse lipoatrophy, I would have started them ages ago when speculation first began that they might be of use.There are good reasons why these agents MIGHT help, but studies so far have not been miraculous, though some improvements have been noted.  Some improvements have been noted by measurements and x-rays, but there  has not been dramatic improvement in terms of what patients see, which is really what is important.I'm continuing to keep my ears open, and maybe reliable benefit will be found sometime.   I'm more optimistic about piogitazone than rosiglitazone, but not enough to pop more pills.  Despite what some think on this list may think, I'm a most enthusiastic supporter of taking the lowest number of drugs possible.In the back of my mind, there is the spectre of Rezulin®, a related drug that killed a few folks.   Wait and see........On Feb 19, 2006, at 8:23 AM, PozHealth wrote:I read yesterday that both rosiglitazine and pioglitazone both increase  limb  fat. Having skinny legs from zerit. I started it on April 1997 and took it   for 2 1/2 yrs till dec 99.... 6 yrs later and no fat has returned,, SO which of   the drugs would you suggest  as least side effects and  dosage..   and most  effective etc..  currently on truvada and .sustiva  and  vl<50 and cd4 500's..  thanks... I tried leg workouts but the skinniness  remains the same  esp w/  lots of veins showing from the knee to the  ankle... this is where it looks the  thinnest  any ideas.. thank you,,  luke Barrowpozbod@...

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