New Drugs for HIV

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Drugs in DevelopmentTMC114 Powers Through Latest Clinical TrialThe experimental protease inhibitor TMC114 continues to impress in clinical trials. A phase 2B study presented at IAS 2005 found that at its ideal dose, TMC114 + ritonavir (Norvir) significantly outperforms many other protease inhibitors in treatment-experienced people whose virus has at least one mutation associated with protease inhibitor resistance. TMC114 even appears to work well without the help of T-20 (enfuvirtide, Fuzeon). Dr. Mark Wainberg reports.Reverset Active Against NRTI-Resistant Virus; Caution Against Use With ddI, 3TCAn NRTI in development known as Reverset (D-D4FC) has shown potency in people who have already developed resistance to some NRTIs, according to the results of a phase 2B study presented at IAS 2005. The drug also appears to cause only mild side effects. However, it looks like Reverset and ddI (didanosine, Videx) will not make a safe combination, and Reverset may also not work as well when taken with 3TC (lamivudine, Epivir). Dr. Mark Wainberg reports for The Body.Early Study Shows Promise for GW695634, a Next-Generation NNRTIGW695634 is a next-generation NNRTI in the early stages of clinical development, and signs so far appear promising. A seven-day monotherapy study showed that the drug had a strong anti-HIV response in people who had already developed resistance to existing NNRTIs. Dr. Mark Wainberg reports for The Body from IAS 2005.

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