Re: Selenium overdose and relationship to thyroid

[Guest guest]

I also found were

> selenium might make more T3 from circulating T4, so I guess this

> actually could be a thyroid problem being created by the selenium.

> Adding selenium could make my Armour thyroid dose too high.

1: Biol Trace Elem Res. 1996 Jan;51(1):31-41. Links

Selenium, zinc, and thyroid hormones in healthy subjects: low T3/T4

ratio in the elderly is related to impaired selenium status.Olivieri

O, Girelli D, Stanzial AM, Rossi L, Bassi A, Corrocher R.

Institute of Medical Pathology, University of Verona, Italy.

Iodothyronine 5' deiodinase, which is mainly responsible for

peripheral T3 production, has recently been demonstrated to be a

selenium (Se)-containing enzyme. The structure of nuclear thyroid

hormone receptors contains Zinc (Zn) ions, crucial for the functional

properties of the protein. In the elderly, reduced peripheral

conversion of T4 to T3 with a lower T3/T4 ratio and overt

hypothyroidism are frequently observed. We measured serum Se and RBC

GSH-Px (as indices of Se status), circulating and RBC Zinc (as

indices of Zn status), thyroid hormones and TSH in 109 healthy

euthyroid subjects (52 women, 57 men), carefully selected to avoid

abnormally low thyroid hormone levels induced by acute or chronic

diseases or calorie restriction. The subjects were subdivided into

three age groups. To avoid under- or malnutrition conditions, dietary

records were obtained for a sample of 24 subjects, randomly selected

and representative of the whole population for age and sex. Low T3/T4

ratios and reduced Se and RBC GSH-Px activity were observed only in

the older group. A highly significant linear correlation between the

T3/T4 ratio and indices of Se status was observed in the older group

of subjects (r = 0.54; p < 0.002, for Se; r = 0.50; p < 0.002, for

RBC GSH-Px). Indices of Zn status did not correlate with thyroid

hormones, but RBC Zn was decreased in older as compared with younger

subjects. We concluded that reduced peripheral T4 conversion is

related to impaired Se status in the elderly.

PMID: 8834378 [PubMed - indexed for MEDLINE]

>

> a Carnes

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[Guest guest]

a, I usually test deficient in zinc, and zinc is supposed to be good for hypothyroids, but I swear, everytime I take it for any length of time, it gives me all kinds of hyperthyroid symptoms. Just like you're describing. Heart racing, sweaty, anxious, diarrhea, etc. Those are definitely hyperthyroid symptoms. It's possible the selenium is helping your thryoid so you need less Armour. I took armour for quite a few years, and I could always feel its effect immediately. At some point, I started producing more T3 on my own, which means the Armour ratio of 20/80 T3/T4 was too high for me, and I started having hyper type reactions. I've since switched to the straight T4, but even that gives me the restless/wired feeling I don't like. Takes melatonin to get me to sleep. And yet my TSH is around 14. Normally I feel best at around 1 or less. Go figure. pennypjeanneus

<pj7@...> wrote: I also found were > selenium might make more T3 from circulating T4, so I guess this > actually could be a thyroid problem being created by the selenium. > Adding selenium could make my Armour thyroid dose too high.1: Biol Trace Elem Res. 1996 Jan;51(1):31-41. Links Selenium, zinc, and thyroid hormones in healthy subjects: low T3/T4 ratio in the elderly is related to impaired selenium status.Olivieri O, Girelli D, Stanzial AM, Rossi L, Bassi A, Corrocher R.

Institute of Medical Pathology, University of Verona, Italy.Iodothyronine 5' deiodinase, which is mainly responsible for peripheral T3 production, has recently been demonstrated to be a selenium (Se)-containing enzyme. The structure of nuclear thyroid hormone receptors contains Zinc (Zn) ions, crucial for the functional properties of the protein. In the elderly, reduced peripheral conversion of T4 to T3 with a lower T3/T4 ratio and overt hypothyroidism are frequently observed. We measured serum Se and RBC GSH-Px (as indices of Se status), circulating and RBC Zinc (as indices of Zn status), thyroid hormones and TSH in 109 healthy euthyroid subjects (52 women, 57 men), carefully selected to avoid abnormally low thyroid hormone levels induced by acute or chronic diseases or calorie restriction. The subjects were subdivided into three age groups. To avoid under- or malnutrition conditions, dietary records were

obtained for a sample of 24 subjects, randomly selected and representative of the whole population for age and sex. Low T3/T4 ratios and reduced Se and RBC GSH-Px activity were observed only in the older group. A highly significant linear correlation between the T3/T4 ratio and indices of Se status was observed in the older group of subjects (r = 0.54; p < 0.002, for Se; r = 0.50; p < 0.002, for RBC GSH-Px). Indices of Zn status did not correlate with thyroid hormones, but RBC Zn was decreased in older as compared with younger subjects. We concluded that reduced peripheral T4 conversion is related to impaired Se status in the elderly.PMID: 8834378 [PubMed - indexed for MEDLINE]> > a Carnes>