Re: A bit out of left field

[Guest guest]

Thanks... I am actually interested in this class of antipsychotics.

They are also antimicrobial... very weakly so, but on the other hand

they are very much concentrated in macrophages.

>

> Curr Eye Res (1992) 11: 843-8.

>

> The effect of chlorpromazine on endotoxin-induced uveitis in the

rat.

[Guest guest]

I am always interested in anything (besides steroids) to dampen

the inflammation of Uveitis.

Interesting. If it's been known since 1992 I wonder why it was never

suggested to me to try it during the years of 1995 thru 2002 as I was

refusing steroids on a regular basis.

If I still had the same eye Doc- I'd ask him.

Barb

>

> Curr Eye Res (1992) 11: 843-8.

>

> The effect of chlorpromazine on endotoxin-induced uveitis in the

rat.

>

> L Kasner, CC Chan, E Cordella-Miele, I Gery

> Laboratory of Immunology, National Eye Institute, National

Institutes of Health, Bethesda, MD 20892.

> Chlorpromazine (CPZ) has been used extensively in the treatment of

psychiatric disorders, and has recently been shown to possess

systemic anti-inflammatory properties as well. To investigate the

potential effects of CPZ on ocular inflammation, we evaluated its

action on endotoxin-induced uveitis (EIU) in rats. At three

different dosage levels, CPZ produced highly significant reductions

in the mean aqueous aspirate inflammatory cell counts and

histological inflammatory scores as compared to controls treated with

vehicle only. Analysis of aqueous fluid demonstrated a similar

decrease in protein concentration and phospholipase A2 (PLA-2)

activity in the treated animals. The ability of CPZ to inhibit the

development of EIU may be related to its properties as a calcium

channel blocker and inhibitor of the enzyme phospholipase A2.

>

> [Pubmed Record - new window]

>

> Browse via Keywords: Chlorpromazine, CPZ, endotoxin-induced,

uveitis, , EIU, psychiatric, inflammatori, aqueous, anti-

inflammatori, disorders, ocular, possess, extensively, inflammatory,

dosage, phospholipase, highli, potential, recently, treatment,

evaluated, aspirate, phospholipas a2, scores, shown, A2, vehicle,

reductions, histological, counts, treatment, PLA-2, fluid, rats,

significant, blocker, decrease, channels, concentration, animals,

calcium, Analysis, similar, ability, demonstrated, compared,

inhibitor, inhibit, enzyme, cell, protein,

>

[Guest guest]

Take a look at Hydroxyzine...

Clariton is the same drug- just lacking the braining capability.

Hydroxyzine can be prescirbed for anexiety and is also prescribed and

works great GREAT on skin /uticaria hives- etc...

Maybe it's been around longer.

Barb

> >

> > Curr Eye Res (1992) 11: 843-8.

> >

> > The effect of chlorpromazine on endotoxin-induced uveitis in

the

> rat.

> >

> > L Kasner, CC Chan, E Cordella-Miele, I Gery

> > Laboratory of Immunology, National Eye Institute, National

> Institutes of Health, Bethesda, MD 20892.

> > Chlorpromazine (CPZ) has been used extensively in the treatment

of

> psychiatric disorders, and has recently been shown to possess

> systemic anti-inflammatory properties as well. To investigate the

> potential effects of CPZ on ocular inflammation, we evaluated its

> action on endotoxin-induced uveitis (EIU) in rats. At three

> different dosage levels, CPZ produced highly significant

reductions

> in the mean aqueous aspirate inflammatory cell counts and

> histological inflammatory scores as compared to controls treated

with

> vehicle only. Analysis of aqueous fluid demonstrated a similar

> decrease in protein concentration and phospholipase A2 (PLA-2)

> activity in the treated animals. The ability of CPZ to inhibit

the

> development of EIU may be related to its properties as a calcium

> channel blocker and inhibitor of the enzyme phospholipase A2.

> >

> > [Pubmed Record - new window]

> >

> > Browse via Keywords: Chlorpromazine, CPZ, endotoxin-induced,

> uveitis, , EIU, psychiatric, inflammatori, aqueous, anti-

> inflammatori, disorders, ocular, possess, extensively,

inflammatory,

> dosage, phospholipase, highli, potential, recently, treatment,

> evaluated, aspirate, phospholipas a2, scores, shown, A2, vehicle,

> reductions, histological, counts, treatment, PLA-2, fluid, rats,

> significant, blocker, decrease, channels, concentration, animals,

> calcium, Analysis, similar, ability, demonstrated, compared,

> inhibitor, inhibit, enzyme, cell, protein,

> >

>

[Guest guest]

<rwindsor@...> wrote:

>

> Dear Barb

> The answer is dead simple. Crosing professional boundaries is a no-

no. Using a psychiatric medication for a non-psychiatric problem

(whether we enter the debate of infection versus autoimmune is

irrelevant). Professional isolation (via the peer review process or

not) is a major problem.

> Regards

> Windsor

I dono - I think the primary factor is that most of those drugs have

a funky rap sheet. Chlorpromazine and some others rather commonly

cause tardive dyskinesia, a movement problem. I seem to recall that

it doesnt always go away when the drug is stopped. How rare/common

that is I dono. Wikipedia confirms this, not that they are always

right about things or give the right impression:

" There is a significant risk of the serious condition tardive

dyskinesia developing as a side effect of typical antipsychotics. The

risk of developing tardive dyskinesia after chronic typical

antipsychotic usage varies on several factors, such as age and

gender. The commonly reported incidence of TD among younger patients

is about 5% per year. Among older patients incidence rates as high

than 20% per year have been reported. The average prevalence is

approximately 30% [1]. There are no treatments that have consistently

been shown to be effective for the treatment of tardive dyskinesias,

however branched chain amino acids, melatonin, and vitamin E have

been suggested as possible treatments. The atypical antipsychotic

clozapine has also been suggested as an alternative antipsychotic for

patients experiencing tardive dyskinesia. Tardive dyskinesia may

reverse upon discontinuation of the offending agent or it may be

irreversible. "