Guest guest Posted July 6, 2006 Report Posted July 6, 2006 Yes I was taking Cimetidine & zinc as per the extracts below ..I say was because I have stopped for a while. The effect of cimetidine was immediate ..The allergic response to my pathogens [hay fever type symptoms] was halted ..a couple of weeks into the therapy I decided to cut back on ABX's to see if my IS would kick in...It didn't , my infection grew and its took quite large amounts of ABX's to get back on top .As per the extracts the time scale is in many months so perhaps it was too soon to reduce ABX's...Another factor could be the altered PH in the gut that has adversely affected the absorbsion of the ABX's , It's a known side affect of the drug .I suppose the next step is to resume therapy both the Cimetidine & ABX and monitor the situation. There quite a sprinkling of info on the drug [below] This first extract is very telling ,CMC is up to now was considered incurable , a genetic flaw was suspected ..So this news is big news , Tagamet is Cimetidine, I see that cimetidine is responsible for an increased CD4 (helper/inducer)cell count , well that’s interesting because latest research has revealedthat a particular bacterium is responsible for the production of CD4. So does a reduced acidic environment favour the growth of Bacteroidesfragilis, the bacterium in question? , Your Dr is quoting the text book in telling you everyone reacts allergic to yeast, the thing is we are beyond the books.. Specialist have found that yeast downgrades the IS so the allergic response is very weak or none existent ...Only a hypersensitivity test will prove an allergic reaction is present Search "Dr Cranton Yeast" for his take on this ..or look him up in the reference section of my site ... Am J Med Sci. 1996 Apr;311(4):189-90. Related Articles, Links Case report: successful treatment with cimetidine and zinc sulphate in chronic mucocutaneous candidiasis. Polizzi B, Origgi L, Zuccaro G, Matti P, Scorza R. Institute of Internal Medicine, Infectious Disease and Immunopathology, Univerity of Milan, Italy. The authors evaluated the clinical efficacy of a treatment with cimetidine and zinc sulphate in a patient with chronic mucocutaneous candidiasis. Cimetidine was given at a dose of 400 mg three times daily; zinc sulphate at a dose of 200 mg daily, then adjusted to maintain blood zinc levels at the upper normal range. This treatment lasted 16 months. An impressive and significant reduction of the infectious events and an increased CD4 (helper/inducer) cell counts were observed. The authors conclude that this combined immunopotentiating treatment is safe and inexpensive to treat immunodeficiency disorders. Publication Types:Case Reports PMID: 8602650 [PubMed - indexed for MEDLINE] Ann Intern Med. 1980 Feb;92(2 Pt 1):192-5. Related Articles, Links Cimetidine as an immunomodulator: chronic mucocutaneous candidiasis as amodel. Jorizzo JL, Sams WM Jr, Jegasothy BV, Olansky AJ. Four adult patients with chronic mucocutaneous candidiasis were studied toestablish a possible role for cimetidine as an immunomodulator. Thesepatients had negative baseline in-vivo and in-vitro cell-mediated immuneresponse to candida antigen as measured by intradermal skin tests,lymphocyte transformation, and leukocyte migration inhibitory factorproduction to cimetidine, 300 mg by mouth, four times daily. Subsequentlyfour of four patients developed strong (greater than 15 mm) intradermal skintest reactions, and two of four patients produced leukocyte migrationinhibitory factor to candida antigen. Skin tests and leukocyte migrationinhibitory factor production reverted to baseline negative values whenrepeated 4 weeks after discontinuation of therapy. After 4 additional weekson cimetidine, four of four patients showed strong positive skin tests andleukocyte migration inhibitory factor production to candida antigen.Lymphocyte transformation was not affected by therapy. PMID: 7352725 [PubMed - indexed for MEDLINE] > > http://jmii.org/content/pdf/v37n3p196.pdf Bielory L, Ghafoor S.UMDNJ, New Jersey Medical School, Newark, New Jersey 07103, USA. bielory@...PURPOSE OF REVIEW: The purpose of this review is to evaluate the effect of histamine on various receptors in the conjunctiva. A Medline search from 1980 was performed on the histamine receptor subtypes H1, H2 and H3 in the human conjunctiva. RECENT FINDINGS: In the conjunctiva, histamine has been shown to induce various physiological and immunological changes through both H1 and H2 receptor stimulation. Histamine binding to conjunctival H1 receptors through the phospholipase C-dependent inositol phosphate pathway leads to the symptom of pruritus while histamine stimulation of the conjunctival H2 receptors has been indirectly shown to cause vasodilation. SUMMARY: The effect of histamine on conjunctival H1 receptors appears to be the primary target for ocular allergy treatment as it is primarily involved in ocular pruritus. The exact interaction of the conjunctival H2 receptors appears to work in a complementary fashion to the H1 receptor in controlling other features of ocular allergy such as vasodilation and injection. Thus, oral and topical antihistamines with multiple histamine receptor binding activities may provide an improved treatment paradigm for the various signs and symptoms of ocular allergy. The histamine H1, H2 and H3 receptor affinities of ketotifen, pyrilamine, and epinastine appear to have the strongest H1 and H2 affinities.Publication Types:· ReviewPMID: 16131920 [PubMed - indexed for MEDLINE] Pharmacological properties of histamine receptor subtypes.Arrang JM.Unite de Neurobiologie et Pharmacologie, U.109 de l'INSERM, Centre Broca, Paris, France.Histamine, a ubiquitous cell-to-cell messenger, exerts its numerous actions through interaction with three pharmacologically distinct receptor subtypes, termed H1, H2 and H3. The design of selective agonists and antagonists has allowed to establish their respective pharmacological profile. Radioligand binding studies and, very recently, molecular biological studies have shown that they all belong to the superfamily of G-protein coupled receptors. H1 and H2-receptor antagonists have been successfully used for a long time in the treatment of allergy and ulcer, respectively. Some of them have been designed as highly potent and selective radioligands and have allowed to analyze the precise distribution of H1 and H2 receptors in various tissues including the brain. Recently, H1- and H2-receptor genes have been cloned in various animal species. Transfection of mammalian cells with these intronless genes has confirmed the respective coupling of H1 and H2 receptors with phospholipase C and adenylylcyclase. However, other known or unknown intracellular signals, could also be triggered by the stimulation in a transfected cell of a single H1 or H2 receptor through coupling to different G-proteins. A third histamine receptor subtype, the H3 receptor was evidenced in rodent and human brain by the inhibition of histamine release and synthesis it mediates in various areas. Thus, H3 receptors were considered as autoreceptors localized on histaminergic terminals. With the design of several potent and selective H3-receptor agonists and of an antagonist thioperamide, the critical role of H3 receptors in the control of histaminergic neurons in vivo was established.(ABSTRACT TRUNCATED AT 250 WORDS)Publication Types:· ReviewPMID: 7920174 [PubMed - indexed for MEDLINE]Pak J Pharm Sci. 2005 Apr;18(2):55-60. Related Articles, LinksIn vitro release of tetracyclines in presence of H2-receptor antagonists.Iftikhar A, Arayne MS, Sultana N.Faculty of Pharmacy, Hamdard University, Karachi.There are a number of drug interactions reported for tetracyclines with many other drugs. In present study in vitro release of five different tetracyclines i.e., tetracycline, demeclocycline, oxytetracycline, methacycline and doxycycline in presence of cimetidine and ranitidine has been studied by USP XX dissolution method. The release of almost all tetracyclines was depressed in presence of cimetidine and ranitidine while in some cases the value were greatly increased due to the formation of charge transfer complexes of the antibiotic with H2-receptor antagonists, which gave absorbance at same wavelengths but with much higher molar absorptivity. An attempt was made to elucidate the mechanism of this effect.PMID: 16431401 [PubMed - indexed for MEDLINE]Gan To Kagaku Ryoho. 2005 Oct;32(11):1576-7. Related Articles, Links [The effect of cimetidine mainly increases CD4+ cells of peripheral blood T lymphocytes][Article in Japanese]Asakage M, Tsuno NH, Kitayama J, Yamada J, Tsuchiya T, Yoneyama S, Takahashi K, Nagawa H.Dept of Surgical Oncology, University of Tokyo.Cimetidine, one of the most popular histamine-2 receptor antagonists, has been reported to improve survival in gastrointestinal cancer patients and to activate cell-mediated immune response in surgical patients. NKT cells are a population of T cells that share characteristics with natural killer cells, and their main functions are production of immunoregulatory cytokines and cytolytic activities. In this study, we aimed to investigate the effect of cimetidine on the cell-mediated immunoresponse. Six healthy adult volunteers were given 800 mg of cimetidine per day orally, and their blood samples were taken prior to and at days 1, 3, 5, and 7 days post-administration of cimetidine. Leukocyte counts and differentials were obtained by the conventional hemogram, and the leukocyte subsets were analyzed by flow cytometry. Cimetidine administration caused leukocytosis, dependent on the increase of neutrophils, as well as of the CD3-positive T lymphocytes, and the subset of CD4-positive cells among them. On the other hand, the NK cell subpopulation was decreased, and the NKT cell subpopulation was not affected. The present results suggest that cimetidine is a modulator of the cellular immunity, and may be used as the activator of the tumor specific immunoresponse.PMID: 16315874 [PubMed - indexed for MEDLINE] [infections] Candida allergy> >> >> > I've been told that I am allergic to Candida. If anyone else has,> > please could they share their experiences with treatments?> >> >> >> >> Quote
Guest guest Posted July 6, 2006 Report Posted July 6, 2006 , :Have you seen any other sites talking about cimetidine? It seems to be a wonder drug of sorts, and yet there doesn't seem to be a buzz out there. Unless it's on forums I don't frequent. I know Dr. Goldstein became very frustrated when his colleagues paid no attention to his claim that Cimetedine could cure mono in 3 days. And Goldstein wasn't considered a quack, he was well respected for his other research. It's unfortunate that the patent is expired, because it means there's no motivation to put money into researh that won't make a return. But there are enough studies on cimetidine to show that it's a drug with very interesting potential. penny Jaep <Jaep@...> wrote: Yes I was taking Cimetidine & zinc as per the extracts below ..I say was because I have stopped for a while. The effect of cimetidine was immediate ..The allergic response to my pathogens [hay fever type symptoms] was halted ..a couple of weeks into the therapy I decided to cut back on ABX's to see if my IS would kick in...It didn't , my infection grew and its took quite large amounts of ABX's to get back on top .As per the extracts the time scale is in many months so perhaps it was too soon to reduce ABX's...Another factor could be the altered PH in the gut that has adversely affected the absorbsion of the ABX's , It's a known side affect of the drug .I suppose the next step is to resume therapy both the Cimetidine & ABX and monitor the situation. There quite a sprinkling of info on the drug [below] This first extract is very telling ,CMC is up to now was considered incurable , a genetic flaw was suspected ..So this news is big news , Tagamet is Cimetidine, I see that cimetidine is responsible for an increased CD4 (helper/inducer)cell count , well that’s interesting because latest research has revealedthat a particular bacterium is responsible for the production of CD4. So does a reduced acidic environment favour the growth of Bacteroidesfragilis, the bacterium in question? , Your Dr is quoting the text book in telling you everyone reacts allergic to yeast, the thing is we are beyond the books.. Specialist have found that yeast downgrades the IS so the allergic response is very weak or none existent ...Only a hypersensitivity test will prove an allergic reaction is present Search "Dr Cranton Yeast" for his take on this ..or look him up in the reference section of my site ... Am J Med Sci. 1996 Apr;311(4):189-90. Related Articles, Links Case report: successful treatment with cimetidine and zinc sulphate in chronic mucocutaneous candidiasis. Polizzi B, Origgi L, Zuccaro G, Matti P, Scorza R. Institute of Internal Medicine, Infectious Disease and Immunopathology, Univerity of Milan, Italy. The authors evaluated the clinical efficacy of a treatment with cimetidine and zinc sulphate in a patient with chronic mucocutaneous candidiasis. Cimetidine was given at a dose of 400 mg three times daily; zinc sulphate at a dose of 200 mg daily, then adjusted to maintain blood zinc levels at the upper normal range. This treatment lasted 16 months. An impressive and significant reduction of the infectious events and an increased CD4 (helper/inducer) cell counts were observed. The authors conclude that this combined immunopotentiating treatment is safe and inexpensive to treat immunodeficiency disorders. Publication Types:Case Reports PMID: 8602650 [PubMed - indexed for MEDLINE] Ann Intern Med. 1980 Feb;92(2 Pt 1):192-5. Related Articles, Links Cimetidine as an immunomodulator: chronic mucocutaneous candidiasis as amodel. Jorizzo JL, Sams WM Jr, Jegasothy BV, Olansky AJ. Four adult patients with chronic mucocutaneous candidiasis were studied toestablish a possible role for cimetidine as an immunomodulator. Thesepatients had negative baseline in-vivo and in-vitro cell-mediated immuneresponse to candida antigen as measured by intradermal skin tests,lymphocyte transformation, and leukocyte migration inhibitory factorproduction to cimetidine, 300 mg by mouth, four times daily. Subsequentlyfour of four patients developed strong (greater than 15 mm) intradermal skintest reactions, and two of four patients produced leukocyte migrationinhibitory factor to candida antigen. Skin tests and leukocyte migrationinhibitory factor production reverted to baseline negative values whenrepeated 4 weeks after discontinuation of therapy. After 4 additional weekson cimetidine, four of four patients showed strong positive skin tests andleukocyte migration inhibitory factor production to candida antigen.Lymphocyte transformation was not affected by therapy. PMID: 7352725 [PubMed - indexed for MEDLINE] > > http://jmii.org/content/pdf/v37n3p196.pdf Bielory L, Ghafoor S.UMDNJ, New Jersey Medical School, Newark, New Jersey 07103, USA. bielory@...PURPOSE OF REVIEW: The purpose of this review is to evaluate the effect of histamine on various receptors in the conjunctiva. A Medline search from 1980 was performed on the histamine receptor subtypes H1, H2 and H3 in the human conjunctiva. RECENT FINDINGS: In the conjunctiva, histamine has been shown to induce various physiological and immunological changes through both H1 and H2 receptor stimulation. Histamine binding to conjunctival H1 receptors through the phospholipase C-dependent inositol phosphate pathway leads to the symptom of pruritus while histamine stimulation of the conjunctival H2 receptors has been indirectly shown to cause vasodilation. SUMMARY: The effect of histamine on conjunctival H1 receptors appears to be the primary target for ocular allergy treatment as it is primarily involved in ocular pruritus. The exact interaction of the conjunctival H2 receptors appears to work in a complementary fashion to the H1 receptor in controlling other features of ocular allergy such as vasodilation and injection. Thus, oral and topical antihistamines with multiple histamine receptor binding activities may provide an improved treatment paradigm for the various signs and symptoms of ocular allergy. The histamine H1, H2 and H3 receptor affinities of ketotifen, pyrilamine, and epinastine appear to have the strongest H1 and H2 affinities.Publication Types:· ReviewPMID: 16131920 [PubMed - indexed for MEDLINE] Pharmacological properties of histamine receptor subtypes.Arrang JM.Unite de Neurobiologie et Pharmacologie, U.109 de l'INSERM, Centre Broca, Paris, France.Histamine, a ubiquitous cell-to-cell messenger, exerts its numerous actions through interaction with three pharmacologically distinct receptor subtypes, termed H1, H2 and H3. The design of selective agonists and antagonists has allowed to establish their respective pharmacological profile. Radioligand binding studies and, very recently, molecular biological studies have shown that they all belong to the superfamily of G-protein coupled receptors. H1 and H2-receptor antagonists have been successfully used for a long time in the treatment of allergy and ulcer, respectively. Some of them have been designed as highly potent and selective radioligands and have allowed to analyze the precise distribution of H1 and H2 receptors in various tissues including the brain. Recently, H1- and H2-receptor genes have been cloned in various animal species. Transfection of mammalian cells with these intronless genes has confirmed the respective coupling of H1 and H2 receptors with phospholipase C and adenylylcyclase. However, other known or unknown intracellular signals, could also be triggered by the stimulation in a transfected cell of a single H1 or H2 receptor through coupling to different G-proteins. A third histamine receptor subtype, the H3 receptor was evidenced in rodent and human brain by the inhibition of histamine release and synthesis it mediates in various areas. Thus, H3 receptors were considered as autoreceptors localized on histaminergic terminals. With the design of several potent and selective H3-receptor agonists and of an antagonist thioperamide, the critical role of H3 receptors in the control of histaminergic neurons in vivo was established.(ABSTRACT TRUNCATED AT 250 WORDS)Publication Types:· ReviewPMID: 7920174 [PubMed - indexed for MEDLINE]Pak J Pharm Sci. 2005 Apr;18(2):55-60. Related Articles, LinksIn vitro release of tetracyclines in presence of H2-receptor antagonists.Iftikhar A, Arayne MS, Sultana N.Faculty of Pharmacy, Hamdard University, Karachi.There are a number of drug interactions reported for tetracyclines with many other drugs. In present study in vitro release of five different tetracyclines i.e., tetracycline, demeclocycline, oxytetracycline, methacycline and doxycycline in presence of cimetidine and ranitidine has been studied by USP XX dissolution method. The release of almost all tetracyclines was depressed in presence of cimetidine and ranitidine while in some cases the value were greatly increased due to the formation of charge transfer complexes of the antibiotic with H2-receptor antagonists, which gave absorbance at same wavelengths but with much higher molar absorptivity. An attempt was made to elucidate the mechanism of this effect.PMID: 16431401 [PubMed - indexed for MEDLINE]Gan To Kagaku Ryoho. 2005 Oct;32(11):1576-7. Related Articles, Links [The effect of cimetidine mainly increases CD4+ cells of peripheral blood T lymphocytes][Article in Japanese]Asakage M, Tsuno NH, Kitayama J, Yamada J, Tsuchiya T, Yoneyama S, Takahashi K, Nagawa H.Dept of Surgical Oncology, University of Tokyo.Cimetidine, one of the most popular histamine-2 receptor antagonists, has been reported to improve survival in gastrointestinal cancer patients and to activate cell-mediated immune response in surgical patients. NKT cells are a population of T cells that share characteristics with natural killer cells, and their main functions are production of immunoregulatory cytokines and cytolytic activities. In this study, we aimed to investigate the effect of cimetidine on the cell-mediated immunoresponse. Six healthy adult volunteers were given 800 mg of cimetidine per day orally, and their blood samples were taken prior to and at days 1, 3, 5, and 7 days post-administration of cimetidine. Leukocyte counts and differentials were obtained by the conventional hemogram, and the leukocyte subsets were analyzed by flow cytometry. Cimetidine administration caused leukocytosis, dependent on the increase of neutrophils, as well as of the CD3-positive T lymphocytes, and the subset of CD4-positive cells among them. On the other hand, the NK cell subpopulation was decreased, and the NKT cell subpopulation was not affected. The present results suggest that cimetidine is a modulator of the cellular immunity, and may be used as the activator of the tumor specific immunoresponse.PMID: 16315874 [PubMed - indexed for MEDLINE] [infections] Candida allergy> >> >> > I've been told that I am allergic to Candida. If anyone else has,> > please could they share their experiences with treatments?> >> >> >> >> Quote
Guest guest Posted July 6, 2006 Report Posted July 6, 2006 No Penny , That's it below ,all I know .It does seem strange that the drug is not more widely discussed , don't know ! Didn't know about Dr Goldstein either , any more on him & his info on Cimetidine... [infections] Candida allergy> >> >> > I've been told that I am allergic to Candida. If anyone else has,> > please could they share their experiences with treatments?> >> >> >> >> Quote
Guest guest Posted July 7, 2006 Report Posted July 7, 2006 Exactly why there's no buzz. Can't make money on it - although they could change the collor of the pill and remarket it and probably get a few billion before people figured it was the same as what you can buy over the counter. If it increases Tcells- then it would be good for people who were slightly or overtly immunosupressed... I'd like to see what it does to an RA patient- ENBREL is a T cell supressor- but can't remember which calss off hand.. I wonder it it would exacerbate RA (I can't get my RA friend to try it- can't blame her though). Barb > > > > >Hello ,glad you made it here ,what tests did you take to lead > to the > > >allergic conclusion ..If you are allergic to Yeast then that's a > very good > > >sign, People who are not infected show a normal allergic response > to the > > >skin hypersensitivity test , that is ,inject a small amount of > Candida under > > >the skin and observe the reaction, a nice big red bump = an > allergic > > >reaction ..Most with a yeast infection show no or very little > reaction, a > > >sign of how the yeast dampens down the immune response ... > > > > > > > > > [infections] Candida allergy > > > > > > > > > I've been told that I am allergic to Candida. If anyone else has, > > > please could they share their experiences with treatments? > > > > > > > > > > > > > > > Quote
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