Re: Biofilms and Chronic Infection

[Guest guest]

Penny, Good question. I will ask around and get back to you, I don't

know of any reasearch in either of the areas you have indicated. I

have seen the results of one study in Georgia that was presented by

Dr. Alavidze and I have asked her for that.

If clinical studies / case histories count, check out Dr. Wolcott's

web site. In some cases, the infections are cleared in 48 hours and

that has been our experience as well. Healing takes much longer and

can't begin until the infection clears. The time frame depends on the

condition.

The average treatment duration at our outpatient clinic is 10 days,

particularly for chronic urinary, sinus, lung, and intestinal

infections. Osteomyelitis and bone related problems are a different

situation, if there is necrotic tissue that requires debridement.

Hope this is not too repetitive, and I will get back to you with a

more specific reply. Here are references to case histories and some

general information in the science journals:

Case Histories

Dr. Randall Wolcott's case histories, where he is treating chronic,

non-healing wounds with phages (there are two links to his case

histories on this page):

http://www.woundcarecenter.net/csphage.html

Three people who were treated in Georgia for chronic infections and

whose cases made to the mass media; they were:

Alfred Gertler, treated for chronic wound

http://www.cbsnews.com/stories/2002/09/19/48hours/main522596.shtml?

CMP=ILC-SearchStories

Fred Bledsoe, treated for chronic wound - his infection was cleared

in 48 hours. The healing process took substantially longer, as he

was diabetic.

http://www.billingsgazette.com/newdex.php?

display=rednews/2003/02/07/build/health/bacteriophage.inc

Steve Earle - MRSA infection in an artificial joint, he is also the

subject of the White Pines documentary, Killer Cure. It took, I

think, over six weeks to clear his infection, but the problem was

getting the phages into the artificial device - very difficult

surgical procedures and long term irrigation with phage was required.

The phage cocktails required continuous modifications because of the

immune response and some other factors.

http://radio-canada.ca/actualite/v2/enjeux/niveau2_2430.shtml

and you can see videos clips of Steve's case here:

http://www.phagetherapycenter.com/pii/PatientServlet?

command=static_videos & secnavpos=8 & language=0

There are two new publications:

New England Journal of Medicine,

Phages: Their Role in Bacterial Pathogenesis and Biotechnology

Edited by K. Waldor, I. Friedman, and Sankar L. Adhya.

ASM Press

The current issue of Nature Magazine, a News Feature: Bug Killers, by

Hausler. Hausler's book, " Viruses vs. Superbugs " , was

translated to English in June, this the URL of his web site and I

think a blog.

http://www.bacteriophagetherapy.info

In addition I can provide contact with former patients who were

treated for chronic infections. I will only provide patient contact

information to individuals if they contact our clinic, as we always

ask permission of the former patient prior to giving their contact

details. I will not publish the contact information for patients on

the forum.

Scientific Journals

Take a look at the Polish studies, by Weber-Dabrowski and Gorski:

http://www.phageinternational.com/phagetherapy/humantests.htm

Also, look at the bibliographies of these articles:

http://aac.asm.org/cgi/content/full/45/3/649?view=full

http://www.phageinternational.com/phagetherapy/revitalized.pdf

http://www.phageinternational.com/doc/nrd1111.pdf

> > > > > > > >

> > > > > > > > Ps

> > > > > > > > That is a spot on observation of what we are dealing

> > > > > with.Biofilm

> > > > > > > > infections of the sinuses. Many on these forums grow

P

> > > > > > > > aeuriganosa /staph areus and staph epidermis(coag neg

> > > > staphs)..

> > > > > > these

> > > > > > > > are also mentioned in your wound care posts.What

phages

> > > will

> > > > > > attack

> > > > > > > > the coag neg staphs or can you take out the biofilm

> > > > formations

> > > > > by

> > > > > > > > attacking the P aeuriganosa with phage therapy.

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

[Guest guest]

Chris

I think you have a lot of learning to do as far as chronic infections

go.I would take you pyophage and lay a colony of pseudonomads and

staph epi and staph areus and watch for the destruction to occur. The

first thing I learned about treating bacterial infections is you

tailor the drugs to the bugs.I took this a step further and have more

antimicrobial agents than my local hospital for testing samples to

make sure you get the bugs.(amateur microbiologist)

What you need to learn also in a real hurry is that psudonomas

infections or most infections in general DON " T GET ERADICATED EASILY,

but what you observe is management. Everytime my cousin suffers a

cold or flu his strep throat flares and he goes in for the past 20

years to have it managed- IT DOESN " T GET ERADICATED.I don't think

that phages are going to kill anyone when they are an ubundant part

of nature- I do beleieve they can create the actual problems we are

dealing with by passing on information and coding our normal bacteria

to more aggresive forms.So once the horse has bolted everything else

is acceptable.

tony

> > > > > > > >

> > > > > > > > Ps

> > > > > > > > That is a spot on observation of what we are dealing

> > > > > with.Biofilm

> > > > > > > > infections of the sinuses. Many on these forums grow

P

> > > > > > > > aeuriganosa /staph areus and staph epidermis(coag neg

> > > > staphs)..

> > > > > > these

> > > > > > > > are also mentioned in your wound care posts.What

phages

> > > will

> > > > > > attack

> > > > > > > > the coag neg staphs or can you take out the biofilm

> > > > formations

> > > > > by

> > > > > > > > attacking the P aeuriganosa with phage therapy.

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

[Guest guest]

Chris

You can keep all the literature you read and all the crap fed up by

the medical community. I personally get on the phone speak to people

and look for cold hard evidence of cured patients. You really can't

cure many things in 10 days- you got to get past that because most

osteomyelitis is a six week treatment.We love clinical experiences

from the patients mouth, NO_ONE ELSE " S.. the succeses touted are

often fickle short term fixes only to relapse not far into the future

in all our experiences.

tony

> > > > > > > >

> > > > > > > > Ps

> > > > > > > > That is a spot on observation of what we are dealing

> > > > > with.Biofilm

> > > > > > > > infections of the sinuses. Many on these forums grow

P

> > > > > > > > aeuriganosa /staph areus and staph epidermis(coag neg

> > > > staphs)..

> > > > > > these

> > > > > > > > are also mentioned in your wound care posts.What

phages

> > > will

> > > > > > attack

> > > > > > > > the coag neg staphs or can you take out the biofilm

> > > > formations

> > > > > by

> > > > > > > > attacking the P aeuriganosa with phage therapy.

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

[Guest guest]

Chris

It takes ten minutes to learn that bad bacteria ARE BAD BECAUSE OF

THERE ABILITY TO PRODUCE NASTY TOXINS..I think this was the first

lesson I learnt. A month later I was looking for haemolysins and a

good microbiologist. I was so fortunate and a tin arse becuase I got

to befriend one of our cities brightest and highly credentialed

microbiologists.... which meant a whole lot more to me than meeting

the best of the best specialists.I don't know about saving my

own life as it seems the human body can get thrashed to within an

inch and you still survive..often people are walking arouned

suffering unbearable pain for 30 years and more.

tony

> > > > > > > > >

> > > > > > > > > Ps

> > > > > > > > > That is a spot on observation of what we are

dealing

> > > > > > with.Biofilm

> > > > > > > > > infections of the sinuses. Many on these forums

grow

> P

> > > > > > > > > aeuriganosa /staph areus and staph epidermis(coag

neg

> > > > > staphs)..

> > > > > > > these

> > > > > > > > > are also mentioned in your wound care posts.What

> phages

> > > > will

> > > > > > > attack

> > > > > > > > > the coag neg staphs or can you take out the biofilm

> > > > > formations

> > > > > > by

> > > > > > > > > attacking the P aeuriganosa with phage therapy.

> > > > > > > >

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

[Guest guest]

Great. And that makes more sense. That clearing the infection could perhaps happen in ten days but that full healing takes a lot longer. pennypublicspirit <publicspirit@...> wrote: Penny, Good question. I will ask around and get back to you, I don't know of any reasearch in either of the areas you have indicated. I have seen the results of one study in Georgia that was presented by Dr. Alavidze and I have asked her for that. If clinical studies / case histories count, check

out Dr. Wolcott's web site. In some cases, the infections are cleared in 48 hours and that has been our experience as well. Healing takes much longer and can't begin until the infection clears. The time frame depends on the condition.The average treatment duration at our outpatient clinic is 10 days, particularly for chronic urinary, sinus, lung, and intestinal infections. Osteomyelitis and bone related problems are a different situation, if there is necrotic tissue that requires debridement. Hope this is not too repetitive, and I will get back to you with a more specific reply. Here are references to case histories and some general information in the science journals:Case HistoriesDr. Randall Wolcott's case histories, where he is treating chronic, non-healing wounds with phages (there are two links to his case histories on this page):http://www.woundcarecenter.net/csphage.html Three people who were treated in Georgia for chronic infections and whose cases made to the mass media; they were:Alfred Gertler, treated for chronic woundhttp://www.cbsnews.com/stories/2002/09/19/48hours/main522596.shtml?CMP=ILC-SearchStoriesFred Bledsoe, treated for chronic wound - his infection was cleared in 48 hours. The healing process took substantially longer, as he was diabetic.http://www.billingsgazette.com/newdex.php?display=rednews/2003/02/07/build/health/bacteriophage.incSteve Earle - MRSA infection in an artificial joint, he is also the subject of the White Pines documentary, Killer Cure. It took, I

think, over six weeks to clear his infection, but the problem was getting the phages into the artificial device - very difficult surgical procedures and long term irrigation with phage was required. The phage cocktails required continuous modifications because of the immune response and some other factors.http://radio-canada.ca/actualite/v2/enjeux/niveau2_2430.shtmland you can see videos clips of Steve's case here:http://www.phagetherapycenter.com/pii/PatientServlet?command=static_videos & secnavpos=8 & language=0There are two new publications: New England Journal of Medicine,Phages: Their Role in Bacterial Pathogenesis and BiotechnologyEdited by K. Waldor, I. Friedman, and Sankar L.

Adhya. ASM Press The current issue of Nature Magazine, a News Feature: Bug Killers, by Hausler. Hausler's book, "Viruses vs. Superbugs", was translated to English in June, this the URL of his web site and I think a blog.http://www.bacteriophagetherapy.infoIn addition I can provide contact with former patients who were treated for chronic infections. I will only provide patient contact information to individuals if they contact our clinic, as we always ask permission of the former patient prior to giving their contact details. I will not publish the contact information for patients on the forum.Scientific JournalsTake a look at the Polish studies, by Weber-Dabrowski and Gorski: http://www.phageinternational.com/phagetherapy/humantests.htmAlso, look at the bibliographies of these articles:http://aac.asm.org/cgi/content/full/45/3/649?view=fullhttp://www.phageinternational.com/phagetherapy/revitalized.pdfhttp://www.phageinternational.com/doc/nrd1111.pdfChris > > > > > > > >> > > > > > > > Ps> > > > > > > > That is a spot on observation of what we are dealing > > > > > with.Biofilm > > > > > > > > infections of the sinuses. Many on these forums grow P > > > > > > > > aeuriganosa /staph areus and staph epidermis(coag neg > > > > staphs).. > > > > > > these > > > > > > > > are also mentioned in your wound care posts.What phages > > > will > > > > > > attack > > > > > > > > the coag neg staphs or can you take out the biofilm > >

> > formations > > > > > by > > > > > > > > attacking the P aeuriganosa with phage therapy.> > > > > > >> > > > > >> > > > >> > > >> > >> >>