macrophage inactivation by Mtb - STAT1

[Guest guest]

Wow, they are gettin way ahead of where they were when I studied this

last year.

These guys

http://www.jimmunol.org/cgi/content/abstract/176/5/3019

are saying that Mtb prevention of IFN-g activation of macrophages is

TLR-2 dependant. WHY any TLR (which is basically a microbe sensor)

should be hooked up so as to even have the capacity to prevent

macrophage activation, I HAVE NO EARTHLY IDEA. Kind of depressing.

An interesting thing touching CFS is that they claim to have shown

that the STAT1 pathway is working A-OK in Mtb-infected cells. The Mtb

voodoo has a wholly separate pathway.