Re: Magnesium helps protect against tendonitis due to quinolones

[Guest guest]

interesting

On 1 Jun 2006, at 07:49, a Carnes wrote:

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> Magnesium helps protect against tendonitis due to quinolones

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> This article is from 2000 but sheds some light on why quinolones may be

> harmful in Lyme and cfs patients who are often low in magnesium. I have

> had mag. levels tested three times in ten years and am always low. This

> could explain why I developed damaged tendons from extensive

> quinolones,

> Levaquin and Avalox. Cuurently I take about 800 mg a day of magnesium

> taurinate. This has helped my tendons to heal.

>  - a Carnes

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> http://www.prostatitis.org/quinolonejoints.html

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> Antimicrobial Agents and Chemotherapy, February 2000, p. 261-266, Vol.

> 44, No. 2 Ultrastructure of Achilles Tendons of Rats Treated with

> Ofloxacin and Fed a Normal or Magnesium-Deficient Diet Mehdi Shakibaei,

> 1Kerstin Pfister, 2 Rudolf Schwabe, 2 JÃrgen Vormann,3 and Ralf

> Stahlmann 2 ,* Institute of Anatomy, 1Institute of Clinical

> Pharmacology

> and Toxicology, 2and Institute of Molecular Biology and Biochemistry,

> 3 lin Medical Center, Freie Universität

> Berlin, 14195 Berlin, Germany

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> ABSTRACT

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> Fluoroquinolones can cause tendinitis and tendon rupture. However,

> toxicological as well as clinical information on quinolone-induced

> tendopathy is scarce. We performed extensive electron microscopic

> studies with Achilles tendon specimens from ofloxacin-treated rats. The

> drug was given at a dose of 1,200 mg/kg (body weight) orally. Juvenile

> Wistar rats received one or three oral doses each of 1,200 mg of

> ofloxacin/kg (body

> weight)/day.

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> Three days after treatment, the tenocytes of their Achilles tendons

> showed degenerative alterations, such as multiple vacuoles and vesicles

> in the cytoplasm that had developed due to swellings and dilatations of

> cell organelles. Other indications of cell degradation were the

> occurrence of cell debris and cell detachment from the extracellular

> matrix accompanied by a loss of cell-matrix interaction.

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> The tenocytes of juvenile Wistar rats that had been treated at day 36

> with a single oral dose of 1,200 mg of ofloxacin/kg (body weight) and

> sacrificed either 3 or 6 months later exhibited similar degenerative

> alterations. The number of degenerative alterations of tenocytes after

> ofloxacin treatment was considerably higher in rats that had received a

> magnesium-deficient diet than in rats with normal magnesium status. Of

> the adult rats that had been treated once, 5 times, and 10 times with

> ofloxacin and killed 1 day later, only those with the 10-times

> treatment

> showed a significantly increased number of degeneratively altered

> tenocytes. In summary, effects observed in tendons show similar

> pathological features as described earlier in cartilage, indicating

> that

> quinolone-induced arthropathy and quinolone-induced tendopathy probably

> are different clinical manifestations of the same toxic effect on

> cellular components of connective tissue structures.

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