Re: small colony variants - new review by Proctor

[Guest guest]

I forgot to add that Ying Zhang of JHU, a very interesting person,

finds that old (120-day culture), hypometabolic Mtb have a low

transmembrane potential, just like small colony variants do.

It doesnt say, but I think its implied that the 120-day old culture is

in stationary phase. These low-potential cells could be mutants

selected by the stationary phase conditions, but my guess is that its

more likely a phenotypic change.