Re: Inflammation and Cancer: 1006 results

[Guest guest]

I hear Leonard is soon to release a epidemiologic study

suggesting excess cancer (and heart disease, and suicide) in CFS. I

dont think the cancer excess is very high, but I'll be quite

interested to read this paper.

> http://www3.interscience.wiley.com/search/allsearch?

mode=similararticles & DID=109088427 & page=1

>

>

> (Just one of 1006):

>

> Inflammation and Cancer: An Epidemiological Perspective

> Chapter Authors: J. Thun, S. Jane Henley, Ted Gansler

>

> Series: Novartis Foundation Symposia

>

> Summary

> Many chronic inflammatory conditions increase the risk of cancer in

affected tissues. Clinical conditions that involve both inflammation

and increased cancer risk include a broad range of

> immunological disorders, infections (bacterial, helminthic, viral),

and chronic chemical and mechanical irritation. For example, the

inflammatory bowel diseases, ulcerative colitis and Crohn's

> disease, predispose to the development of cancers of the large

bowel and/or terminal ileum; chronic infection with the bacterium

Helicobacter pylori causes atrophic gastritis, dysplasia,

> adenocarcinoma and an unusual form of gastric lymphoma; and

parasitic infection with schistosomes and other trematodes cause

cancers of the urinary bladder and the intrahepatic and extrahepatic

> biliary tract. Chronic reflux of gastric acid and bile into the

distal oesophagus causes chemical injury, Barrett's oesophagus and

oesophageal adenocarcinoma. Chronic cholecystitis and gallstones

> predispose to cancer of the gallbladder. Besides these clinical

syndromes, subclinical inflammation may promote the development of

certain tumours. The expression of COX-2 and lipid mediators of

> inflammation increases during the multistage progression of these

tumours. Non-steroidal anti-inflammatory drugs (NSAIDs), which

inhibit COX-2 activity and tumour development in many experimental

> and clinical settings, are inversely associated with certain

cancers in epidemiological studies. Despite their promise, however,

anti-inflammatory drugs are not yet recommended for the prevention or

> treatment of any cancers. Numerous questions must be resolved

concerning their molecular and cellular targets of action, efficacy,

safety, treatment regimen, indications, and the balance of risks

> and benefits from treatment in designated patient populations.

>

> http://www3.interscience.wiley.com/cgi-

bin/summary/109088427/SUMMARY?CRETRY=1 & SRETRY=0

>

[Guest guest]

Oh yay, that's good news. :-)

Anything we can do to get some attention paid to the seriousness of

this illness, I guess, is a good thing.

penny

>

> I hear Leonard is soon to release a epidemiologic study

> suggesting excess cancer (and heart disease, and suicide) in CFS.