Guest guest Posted July 26, 2004 Report Share Posted July 26, 2004 I gave my old dog DMSO in milk, which is suppose to be the best at disguising the taste. For a 90 lb dog I used 2 teaspoons a day. I also applied a teaspoon a day to her hips topically. I give my horses 2-4 tablespoons a day. They will begin to smell strongly of garlic and this will generally last for a few days after you have stopped giving it. It also makes them need to pee more and drink more since it is a diuretic. IV doses up to 1 mg per kg have been used in humans. DMSO Nature's Healer and MSM the Definitive Guides are two books from Amazon that have been very helpful to me in learning how to use DMSO. Topical application and oral ingestion have longer half lives in the body than IV. It can be given subcutaneously. For IV adminsitration is generally diluted in sterile saline or lactacted ringers at about 100cc DMSO per liter of fluid. IV is given as a slow push. The toxic dose is 40,000 times the therapeutic dose. A transient headache maybe experienced for a short time after ingestion. I have felt this myself and it is very mild for me, well worth the benefits of the DMSO. Garnet > One of my dogs devloped a 106 fever Thursday... he is 7. All his > bloodwork came out fine so my vet and I are thinking this is Shar-Pei > fever. I went looking at Dr. Jeff Vidt's site (he is a Shar-Pei vet) > and came across the below info. My vet is NOT very familiar with > Shar-Pei and their fevers.. I am trying to give her as much info as > possible. So if I gave Paladin the DMSO my questions would be as > follows: How much do I give him? (he is 56 pounds) and exactly HOW > do I give it to him orally? If I do give the DMSO and he does not > have Amyloid, will it hurt him? (I don't think it will, but I want to > ask ) > > I lost one to Amyloid (kidney failure) 8 years ago and I don't want to > lose Paladin the same way if I can help it. He gets a RAW diet and > has not been vaccinated in 5 years (my vet is a holistic vet and is > just fine with the diet and no vaccines) > > Thanks, > Cheri > > > Additional medical therapy may be instituted using either colchicine > tablets or DMSO via injection or orally. The effectiveness of both > these drugs in the prevention and treatment of renal amyloidosis in > the dog has yet to be substantiated, but their use is justified given > the grave prognosis of this condition in the Shar-Pei. Colchicine is a > human anti-gout medication whose mode of action is largely unknown. It > appears to prevent the formation of amyloid in the laboratory, but > whether this occurs in the living animal is not known. Dimethyl > sulfoxide (DMSO) is another drug whose mode of action is unknown, but > has demonstrated the property of dissolving amyloid in the laboratory. > Again, whether this action occurs in the living animal is unknown. > > The dosages are as follows: > A. Colchicine - this dose can be obtained from Dr. Tintle > or myself (see the July/August 1992 issue of The Barker). > B. DMSO - numerous dosages are in the veterinary literature. Your > veterinarian should refer to an excellent article on renal > amyloidosis by DiBartola in Current Veterinary Therapy XI. > > [iMPORTANT! - DMSO imparts an odor to the breath and skin of the > patient.] > > Again, the effectiveness of these drugs in the treatment of > amyloidosis has not been proven in clinical studies and hence, they > should be regarded as experimental drugs for this use. They should be > used only under the supervision of your veterinarian. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2004 Report Share Posted July 27, 2004 Garnet - I ordered both the books and they are on their way. I gave him a 1/4t in his veggie mix this morning and he ate it up and now really smells LOL. I guess my biggest concern, because I don't have the books, is that I am doing something bad to him (poisening him). The DMSO that I got at the HFS says it is 99.9% pure and I used it topically on him with CS but it just worries me that it says on the bottle... "sold as a solvent only". Can you just tell me I am worrying for nothing? Cheri "A dog is the only thing on earth that loves you more than he loves himself." -- Josh Billings XS items: http://www.picturetrail.com/kokosmom2My animals: http://community.webshots.com/user/kokosmom2www.cherik.com Outgoing e-mail scanned by Norton Anti-Virus Re: dog help I gave my old dog DMSO in milk, which is suppose to be the best atdisguising the taste. For a 90 lb dog I used 2 teaspoons a day. I alsoapplied a teaspoon a day to her hips topically. I give my horses 2-4tablespoons a day. They will begin to smell strongly of garlic and thiswill generally last for a few days after you have stopped giving it. Italso makes them need to pee more and drink more since it is a diuretic.IV doses up to 1 mg per kg have been used in humans. DMSO Nature'sHealer and MSM the Definitive Guides are two books from Amazon that havebeen very helpful to me in learning how to use DMSO. Topical applicationand oral ingestion have longer half lives in the body than IV. It can begiven subcutaneously. For IV adminsitration is generally diluted insterile saline or lactacted ringers at about 100cc DMSO per liter offluid. IV is given as a slow push.The toxic dose is 40,000 times the therapeutic dose. A transientheadache maybe experienced for a short time after ingestion. I have feltthis myself and it is very mild for me, well worth the benefits of theDMSO. Garnet> One of my dogs devloped a 106 fever Thursday... he is 7. All his> bloodwork came out fine so my vet and I are thinking this is Shar-Pei> fever. I went looking at Dr. Jeff Vidt's site (he is a Shar-Pei vet)> and came across the below info. My vet is NOT very familiar with> Shar-Pei and their fevers.. I am trying to give her as much info as> possible. So if I gave Paladin the DMSO my questions would be as> follows: How much do I give him? (he is 56 pounds) and exactly HOW> do I give it to him orally? If I do give the DMSO and he does not> have Amyloid, will it hurt him? (I don't think it will, but I want to> ask )> > I lost one to Amyloid (kidney failure) 8 years ago and I don't want to> lose Paladin the same way if I can help it. He gets a RAW diet and> has not been vaccinated in 5 years (my vet is a holistic vet and is> just fine with the diet and no vaccines)> > Thanks, > Cheri> > > Additional medical therapy may be instituted using either colchicine> tablets or DMSO via injection or orally. The effectiveness of both> these drugs in the prevention and treatment of renal amyloidosis in> the dog has yet to be substantiated, but their use is justified given> the grave prognosis of this condition in the Shar-Pei. Colchicine is a> human anti-gout medication whose mode of action is largely unknown. It> appears to prevent the formation of amyloid in the laboratory, but> whether this occurs in the living animal is not known. Dimethyl> sulfoxide (DMSO) is another drug whose mode of action is unknown, but> has demonstrated the property of dissolving amyloid in the laboratory.> Again, whether this action occurs in the living animal is unknown.> > The dosages are as follows: > A. Colchicine - this dose can be obtained from Dr. Tintle> or myself (see the July/August 1992 issue of The Barker). > B. DMSO - numerous dosages are in the veterinary literature. Your> veterinarian should refer to an excellent article on renal> amyloidosis by DiBartola in Current Veterinary Therapy XI. > > [iMPORTANT! - DMSO imparts an odor to the breath and skin of the> patient.]> > Again, the effectiveness of these drugs in the treatment of> amyloidosis has not been proven in clinical studies and hence, they> should be regarded as experimental drugs for this use. They should be> used only under the supervision of your veterinarian.> > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2004 Report Share Posted July 27, 2004 Cheri, As the FDA is set up today, any distributor of DMSO has no choice but to sell it as such. I was once like you in finding that label of "industrial use only, for solvent purposes only" as very intimidating. That is exactly what the FDA wants! I have long changed my mind. As the old cliché goes, "a bad day fishing is worth a good day doing anything else" so it can be said of DMSO, "A bad experience with DMSO is worth a good experience with any other typical FDA approved drug". This label is the law! DMSO cannot be sold over the counter any other way. Just study the toxicity reports on DMSO, plus take it from me, after using it for around 30 years in the most dirty of barn conditions, I have never had a bad experience with it. There is much to be said for this experience. I have long been sold in its safety and its usefulness. doug Re: dog help Garnet - I ordered both the books and they are on their way. I gave him a 1/4t in his veggie mix this morning and he ate it up and now really smells LOL. I guess my biggest concern, because I don't have the books, is that I am doing something bad to him (poisening him). The DMSO that I got at the HFS says it is 99.9% pure and I used it topically on him with CS but it just worries me that it says on the bottle... "sold as a solvent only". Can you just tell me I am worrying for nothing? Cheri Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 28, 2004 Report Share Posted July 28, 2004 The two dangerous contaminants in DMSO manufacture are acetone and heavy metals. Heavy metals from contaminated water are likely not an issue with DMSO made in the US as our water sources are generally pretty pure. You probably get more heavy metals from eating fish or having lead solder in your pipes. Ask where it was made. Also don't buy DMSO made for industrial purposes, this differs from the warning you see on what you bought. Those warnings, as Doug pointed out, are required and are intended to scare people. People have been using DMSO topically for arthritis for over 30 years. I beleive if there were any reported toxicities from this group the Quack Watchers and their ilk would be all over it. I have not seen even ONE bad report. Acetone is a strong smelling substance. It smells like nail polish remover. It may be added to DMSO intended for solvent use in industry, like paint removers, but not in the vet grade you bought. One test for DMSO purity is to put it in the fridge over night (not the freezer!), it freezes at temps below 65, but water or acetone does not. Once it is frozen pour off any excess liquid. It should be water, but if it smells of acetone then, well I would conclude that it is contaminated. Acetone is a kidney toxin. Over a long period of time ingestion of small amounts of acetone would harm healthy kidneys, and could harm someone with kidney disease in a shorter time. Just know where your DMSO comes from and what its intended target market is. I would not buy DMSO from a hardware store that was in the paint remover section or from an unknown source that was selling it too much below vet grade prices. You can buy a pure product from www.jacoblab.com but it is $24 for 8 oz. Vet grade is less than $5 for 16 ounces. Garnet > Garnet - > I ordered both the books and they are on their way. I gave him a 1/4t > in his veggie mix this morning and he ate it up and now really smells > LOL. I guess my biggest concern, because I don't have the books, is > that I am doing something bad to him (poisening him). The DMSO that I > got at the HFS says it is 99.9% pure and I used it topically on him > with CS but it just worries me that it says on the bottle... " sold as > a solvent only " . Can you just tell me I am worrying for nothing? > Cheri > > " A dog is the only thing on earth that loves you more than he loves > himself. " -- Josh Billings > > > XS items: http://www.picturetrail.com/kokosmom2 > My animals: http://community.webshots.com/user/kokosmom2 > www.cherik.com > > Outgoing e-mail scanned by Norton Anti-Virus > > Re: dog help > > I gave my old dog DMSO in milk, which is suppose to be the > best at > disguising the taste. For a 90 lb dog I used 2 teaspoons a > day. I also > applied a teaspoon a day to her hips topically. I give my > horses 2-4 > tablespoons a day. They will begin to smell strongly of garlic > and this > will generally last for a few days after you have stopped > giving it. It > also makes them need to pee more and drink more since it is a > diuretic. > > IV doses up to 1 mg per kg have been used in humans. DMSO > Nature's > Healer and MSM the Definitive Guides are two books from Amazon > that have > been very helpful to me in learning how to use DMSO. Topical > application > and oral ingestion have longer half lives in the body than IV. > It can be > given subcutaneously. For IV adminsitration is generally > diluted in > sterile saline or lactacted ringers at about 100cc DMSO per > liter of > fluid. IV is given as a slow push. > > The toxic dose is 40,000 times the therapeutic dose. A > transient > headache maybe experienced for a short time after ingestion. I > have felt > this myself and it is very mild for me, well worth the > benefits of the > DMSO. > > Garnet > > > > One of my dogs devloped a 106 fever Thursday... he is 7. > All his > > bloodwork came out fine so my vet and I are thinking this is > Shar-Pei > > fever. I went looking at Dr. Jeff Vidt's site (he is a > Shar-Pei vet) > > and came across the below info. My vet is NOT very familiar > with > > Shar-Pei and their fevers.. I am trying to give her as much > info as > > possible. So if I gave Paladin the DMSO my questions would > be as > > follows: How much do I give him? (he is 56 pounds) and > exactly HOW > > do I give it to him orally? If I do give the DMSO and he > does not > > have Amyloid, will it hurt him? (I don't think it will, but > I want to > > ask ) > > > > I lost one to Amyloid (kidney failure) 8 years ago and I > don't want to > > lose Paladin the same way if I can help it. He gets a RAW > diet and > > has not been vaccinated in 5 years (my vet is a holistic > vet and is > > just fine with the diet and no vaccines) > > > > Thanks, > > Cheri > > > > > > Additional medical therapy may be instituted using either > colchicine > > tablets or DMSO via injection or orally. The effectiveness > of both > > these drugs in the prevention and treatment of renal > amyloidosis in > > the dog has yet to be substantiated, but their use is > justified given > > the grave prognosis of this condition in the Shar-Pei. > Colchicine is a > > human anti-gout medication whose mode of action is largely > unknown. It > > appears to prevent the formation of amyloid in the > laboratory, but > > whether this occurs in the living animal is not known. > Dimethyl > > sulfoxide (DMSO) is another drug whose mode of action is > unknown, but > > has demonstrated the property of dissolving amyloid in the > laboratory. > > Again, whether this action occurs in the living animal is > unknown. > > > > The dosages are as follows: > > A. Colchicine - this dose can be obtained from Dr. > Tintle > > or myself (see the July/August 1992 issue of The > Barker). > > B. DMSO - numerous dosages are in the veterinary > literature. Your > > veterinarian should refer to an excellent article on > renal > > amyloidosis by DiBartola in Current Veterinary > Therapy XI. > > > > [iMPORTANT! - DMSO imparts an odor to the breath and skin of > the > > patient.] > > > > Again, the effectiveness of these drugs in the treatment of > > amyloidosis has not been proven in clinical studies and > hence, they > > should be regarded as experimental drugs for this use. They > should be > > used only under the supervision of your veterinarian. > > > > > > Quote Link to comment Share on other sites More sharing options...
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