RE: Re: Phage Therapy

[Guest guest]

, Like everyone else I put the information on the net for consideration , if I express an opinion and that opinion proves to be wrong , & I continue to push opinions that prove to be wrong ..I lose all credibility , do I not .... I find the points made in the reply valid & worth consideration . BTW I was pondering a few weeks back whether I could cease ABX's ... well not to be ..the last end of the month bug growth spurt left me in no doubt that I still need the drugs ....

[infections] Phage Therapy> > > I just downloaded and watched a BBC documentary on Phage Therapy - a> therapy discovered in the 30's and 40's specifically designed for> antibiotic resistant infections.> The documentary talks about how this therapy was developed in the> Soviet Union and more recently, sponsored by an American millionare> and now again, the researh has been split across oceans over patent> disputes.> Has anybody heard of this? The Phage are actually virus designed to> attack specific infection. Here is the blurb on the program I> watched.> > BBC Horizon - The Virus that Cures> ----------------------------------> > VHS>XviD 720x576 647MB 49min> > Channel: BBC2> Date: 1997> > With the rise of MRSA and the so called "superbugs", antibiotics> are becoming less and less effective against an increasing number> of bacteria. What was once an easily teatable infection could now be> potentially fatal. The solution to this crisis could be held by a> tiny research institute in the ex-Soviet republic of Georgia who,> over the past 50 years, have taken a very different approach to> treating infection.> Cheers,> *S*> > > > > > ----------------------------------------------------------------------------> -->

[Guest guest]

Hi, Thanks so much for the info. Phage therapy is very exciting, and may be our one real hope. Are you by any chance affiliated with the company that is getting started just south of the So. Cal. border in Mexico? I had some communications with a rep from there prior to opening. I'm an osteomyelitis patient and think perhaps my situation was deemed too complicated. Another group member, Tony from Australia who is now recovered, got phages from the Republic of Georgia and experimented with them pretty successfully a few years back. Very little cost to him. I would love to do phage therapy, but it seems that with commercialization comes pretty high prices. At least they were at the clinic I was in touch with. Any idea if they'll be made affordable? Also, which specific organisms is your company able to effectively

combat at this point? penny publicspirit <publicspirit@...> wrote: I am involved in a company that is commercializing therapeutic phage preparations, I just joined the group a couple of days ago to observe. When I scanned the messages in search of discussions about phage therapy, I came across a past discussion about safety. Safety is a very common concern of the medical and scientific communities.I frequently travel to

Republic of Georgia, which is the world center for phage therapy. I have sat on the fence during numerous discussions with physicians who use therapeutic phages in their practices. Most Georgian physicians and surgeons are well aware that treatment with phages internally, inside the body, can take place continuously for approximately 15 days. After that period of time the immune system develops antigens for the phages and clears them from the system. Consequently, phage treatment must halt for a few weeks, until those antigens clear, and then treatment can resume for another couple of weeks. For topical use of bacteriophages it is necessary to keep bandages moist with the phage preparation because once the bandage dries, the phages become less effective. For internal use for such conditions as osteomyelitis or some surgical infections it is necessary to continually irrigate the infected area with liquid phages. So,

clearance of phages from the body is definitely not a problem – just the converse: for the practitioner, there is more of a problem keeping the phages constantly applied to the infected areas. Fortunately, bacteriophages act very quickly and infections can typically be cleared within a few days, the normal treatment time frame involved is approximately 10 days.Two other safety factors to consider are in the areas of phage isolation and the toxicology testing that occurs during both clinical trians and during production of the therapeutic phage preparation. Not all phages are equal and the author of the above posting is absolutely correct in stating that some species of phages will exchange genes with certain pathogens, making the bacteria more pathogenic, more dangerous. Those phages that behave in this manner are called lysogenic phages. There have been many scientific papers written on this topic. In fact

part of the holdup in getting the FDA to approve clinical trials is this issue is whether or not the therapeutic phages contain pathogenic genes that can be transferred to the host bacteria. However, only lytic phages are used for therapeutic purposes. Since lytic phages lyse (explode) their host bacteria, the argument of pathogenic gene passing is most likely moot – there are no descendent bacteria to receive such genes, but that argument continues… In addition to validating the efficacy of a particular therapeutic phage, clinical trials also involve toxicology testing. Therapeutic phages of course should not cause the release of massive amounts of toxins during lysis as this could harm the patient.Vast collections of therapeutic phages that have passed such clinical trials are the intellectual properties of both Eliava Institute (Tbilisi, Georgia) and Herzfeld Institute (Wroclaw, Poland). These entities

have been building their therapeutic phage collections for well over 70 years. There is a definite scientific method involved in isolation of the correct lytic phages, toxicology testing, typing various phages to produce effective combinations of phages in a given "phage cocktail", and clinical trials. It appears that many major universities here in the West are now attempting to build libraries or collections of therapeutic phages. One example of this activity is occurring at Evergreen State College: http://www.evergreen.edu/phage <- and this URL is a great place to start learning about phage biology and phage therapy.Phage Therapy is a very important alternative to antibiotics, particularly for those having antibiotic resistant infections. Note, for example, that the Canadian Ministry of Health has just recently begun funding therapeutic phage research (I placed a

link to the program in the Links section of this forum for anyone who might be interested).Bacteriophages are the most ubiquitous life form on the planet and this is the likely reason, according to Dr. Kutter of Evergreen State College, that phage therapy is safe and has no harmful side effects. You've been eating, drinking and wearing phages all your life! Dr. Kutter and Sulakvelidze's book, "Bacteriophages: Biology and Applications" provides great depth of information for many of these areas discussed in this thread. There is also a new translation of a book that was originally published in German in 2003, on the topic of phage therapy; it was written by Hausler, the title is "Viruses vs. Superbugs: A Solution to the Antibiotic Crisis". Both books can be purchased on Amazon.com.Hope this clarifies the safety issue and answers some of the questions that were brought up

in the thread.

[Guest guest]

Thanks for your post , it's good to know the research is ongoing ..Safety would be an issue for most of us here , the obvious fear is introducing virus's that may shall we say linger . It's thought that we host virus's as a co-infection .Our IS do not eradicate those ..You say that the IS will clear the phages ..How can you be so sure ?

Looking at the site below ,the author has a different take, Phages rely on the target bacteria when the bacteria goes so do the phages ..Is this old news? can you explain the apparent contradiction?

I'm not saying throw the idea out .It's just there seems to be contradictions ...

They are both self-replicating and self-limiting, since they will multiply only as long as sensitive bacteria are present and then are gradually eliminated from the individual and the environment.

http://www.evergreen.edu/phage/phagetherapy/phagetherapy.htm

-----Original Message-----From: infections [mailto:infections ]On Behalf Of publicspiritSent: 11 July 2006 03:45infections Subject: [infections] Re: Phage Therapy

I am involved in a company that is commercializing therapeutic phage preparations, I just joined the group a couple of days ago to observe. When I scanned the messages in search of discussions about phage therapy, I came across a past discussion about safety. Safety is a very common concern of the medical and scientific communities.I frequently travel to Republic of Georgia, which is the world center for phage therapy. I have sat on the fence during numerous discussions with physicians who use therapeutic phages in their practices. Most Georgian physicians and surgeons are well aware that treatment with phages internally, inside the body, can take place continuously for approximately 15 days. After that period of time the immune system develops antigens for the phages and clears them from the system. Consequently, phage treatment must halt for a few weeks, until those antigens clear, and then treatment can resume for another couple of weeks. For topical use of bacteriophages it is necessary to keep bandages moist with the phage preparation because once the bandage dries, the phages become less effective. For internal use for such conditions as osteomyelitis or some surgical infections it is necessary to continually irrigate the infected area with liquid phages. So, clearance of phages from the body is definitely not a problem – just the converse: for the practitioner, there is more of a problem keeping the phages constantly applied to the infected areas. Fortunately, bacteriophages act very quickly and infections can typically be cleared within a few days, the normal treatment time frame involved is approximately 10 days.Two other safety factors to consider are in the areas of phage isolation and the toxicology testing that occurs during both clinical trians and during production of the therapeutic phage preparation. Not all phages are equal and the author of the above posting is absolutely correct in stating that some species of phages will exchange genes with certain pathogens, making the bacteria more pathogenic, more dangerous. Those phages that behave in this manner are called lysogenic phages. There have been many scientific papers written on this topic. In fact part of the holdup in getting the FDA to approve clinical trials is this issue is whether or not the therapeutic phages contain pathogenic genes that can be transferred to the host bacteria. However, only lytic phages are used for therapeutic purposes. Since lytic phages lyse (explode) their host bacteria, the argument of pathogenic gene passing is most likely moot – there are no descendent bacteria to receive such genes, but that argument continues… In addition to validating the efficacy of a particular therapeutic phage, clinical trials also involve toxicology testing. Therapeutic phages of course should not cause the release of massive amounts of toxins during lysis as this could harm the patient.Vast collections of therapeutic phages that have passed such clinical trials are the intellectual properties of both Eliava Institute (Tbilisi, Georgia) and Herzfeld Institute (Wroclaw, Poland). These entities have been building their therapeutic phage collections for well over 70 years. There is a definite scientific method involved in isolation of the correct lytic phages, toxicology testing, typing various phages to produce effective combinations of phages in a given "phage cocktail", and clinical trials. It appears that many major universities here in the West are now attempting to build libraries or collections of therapeutic phages. One example of this activity is occurring at Evergreen State College: http://www.evergreen.edu/phage <- and this URL is a great place to start learning about phage biology and phage therapy.Phage Therapy is a very important alternative to antibiotics, particularly for those having antibiotic resistant infections. Note, for example, that the Canadian Ministry of Health has just recently begun funding therapeutic phage research (I placed a link to the program in the Links section of this forum for anyone who might be interested).Bacteriophages are the most ubiquitous life form on the planet and this is the likely reason, according to Dr. Kutter of Evergreen State College, that phage therapy is safe and has no harmful side effects. You've been eating, drinking and wearing phages all your life! Dr. Kutter and Sulakvelidze's book, "Bacteriophages: Biology and Applications" provides great depth of information for many of these areas discussed in this thread. There is also a new translation of a book that was originally published in German in 2003, on the topic of phage therapy; it was written by Hausler, the title is "Viruses vs. Superbugs: A Solution to the Antibiotic Crisis". Both books can be purchased on Amazon.com.Hope this clarifies the safety issue and answers some of the questions that were brought up in the thread.

[Guest guest]

No that's okay. The info you're asking for is really irrelevant. Answers about a treatment should be provided by the healthy people selling it, not the patients. Just in case I wasn't specific enough, I have several basic questions. Which company do you represent? What is the approximate price of treatment? And which bacteria are you able to target at this time? Normally, we don't encourage any kind of marketing efforts here, but I think this is information that most of us would be interested in. By the way, most of us here are battling chronic infections, as will probably a good number of any phage company's potential patients. Most of these patients will have very iffy diagnoses since bacterial testing is so incomplete and under performed here. You may have patients lining up, but If you're expecting them to be lining up with their bacteria

i.d.s in hand so that you can supply the appropriate phage antidote, you'll probably be waiting a long time. That's a problem that any phage company is going to have to address. Getting the bugs identified correctly. Phage companies can also expect some big failures if they treat one infection and miss a co-infection, thereby growing a bigger one. This is what many of us have experienced with partial and incomplete antibiotic therapies. If you're dealing with some kind of sudden, acute infection, that might be another story, but chronic infections are tough. This is a tricky business. I'm very hopeful that phage therapy's going to provide some big breakthroughs for the chronically infected, but I'll need to see exactly how chronic infectious illnesses are going to be managed with phages and whether the results will be any better than what we've seen so far with other antimicrobial

therapies. penny publicspirit <publicspirit@...> wrote: Hello Penny. You did not mention in your post what price you were quoted for treatment nor what you are comparing the price to. Nor did you mention whether or not Tony from Australia is a physician and what was the nature of his medical condition. Can you please provide more information?

[Guest guest]

Well, thanks for the detailed and in-depth reply ,fascinating stuff , I haven't read the links yet I'll look forward to reading them over the next week...Couple of questions , have you any health statistics from Georgia that show clear benefits from the dosing at birth with Phage's. And have you any contact details for the UK researches

Your remarks on gut flora and immunity rings a bell, Its the central them of my web site .In the "Autism is an infectious disease" section one group of pioneering researches [click Bacteroides Frgilis] have found that TH2 is our default setting Immune system.TH1 [adaptive] response is entirely attributable to our interaction with microbes. In short we depend entirely on our symbiotic relationship with our microbial flora for good health ..

http://www.yeast-candida-infections-uk.co.uk/

-----Original Message-----From: infections [mailto:infections ]On Behalf Of publicspiritSent: 13 July 2006 00:42infections Subject: [infections] Re: Phage Therapy

Hi - I'll respond the best way that I am able. I can't really answer your question on behalf of Dr. Kutter. I believe that she and several other prominent American microbiologists are convinced that phage therapy is not ready for the US market because of the potential issue around pathogenic genes, and not so much the clearing issue. Many of the Georgian scientists disagree with this pathogenic gene idea, by the way. Dr. Kutter states in her book that phages appear to be very safe and she does refer patients to the clinics in Georgia via links on her web site. Dr. Kutter wrote that article that you are referring to about 10 years ago, and I believe she was just getting her feet wet at that time. As I understand, the way that the Georgians know the antigens show up is via blood tests that are administered during therapy. This correlates with a reduction in effectiveness during treatment. Here is a paper that lists the major human studies:Minireview - Bacteriophage Therapy: http://aac.asm.org/cgi/content/full/45/3/649. The PDF version has tables showing the various studies that were done in Poland and Russia.and I think this one has some good general information as well:The pospect for bacteriophage therapy in Western medicinehttp://www.phageinternational.com/doc/nrd1111.pdfGiven the host specificity of the phages (described in the above article), why would we care if phages linger in our bodies when they will only infect a specific strain of bacteria? We know this to be true about phages, because they are utilized in the lab for the purpose of identifying specific strains of bacteria. Here's a study that illustrates that we probably are all populated or colonized with phages:Bacteriophage isolation from human salivahttp://www.blackwell-synergy.com/links/doi/10.1046/j.1472-765X.2003.01262.x/abs/We also know that our normal flora consists of various strains of Lactobacillus, Acidophilus, Bifidobacterium, etc. as well as non-pathogenic strains of E.coli, Enterococcus, and even Clostridium. We need these to survive and I wouldn't refer to this as being "infected". Phages may in fact be integral to our immune system.There is great interest in the Western scientific community around using phages to treat bacterial infection - but the Georgians have a 70 year lead. Because their primiary purpose was support of the military, Eliava Institute's funding was substantial during Soviet times, and there is a lot of research there performed by hundreds of scientists over the years. There's is simply much that the Western scientific and medical community still do not know about producing safe and effective therapeutic phage products. There has been, however, some rapid progress in this area in Canada, the US, and the UK.Nearly the entire population of Georgia are treated with phages -- beginning at birth, and this has continued for over 70 years. There are no known side effects. If you contrast that with the side effects of antibiotics -- and the fact that they no longer clear many infections, it would seem worth the risk of being colonized temporarily with benign viruses, if it would clear a painful and potentially deadly infection. Literally millions of people in the US suffer with chronic infections that antibiotics won't touch; hundreds of thousands die every year.

[Guest guest]

Hi Thanks very much for the detailed description and the links. And yes, you have permission to post news at this site, since I think it's something we're all very interested in. I will also post a link to your site in our links/files section. I'm very hopeful about phage therapy and sincerely hope things progress quickly and smoothly for everyone's benefit. I have a couple more questions. I'm curious if you've found a phage cocktail, or are working on one, for actinomyces? This is a very destructive organism, but perhaps not so well known. I'm also curious about the osteomyelitis treatment. Are you able to forego debridement of the necrotic bone and still accomplish a cure? Or is debridement necessary first? Also very happy to hear you've got testing capabilities, as that's been a very big missing piece

for us so far. thanks again, penny publicspirit <publicspirit@...> wrote: Hi Penny,I am one of the founders of Phage International and we are the holding company for the Phage Therapy Center located in Tbilisi, Republic of Georgia. Our HistoryWe started with the idea of establishing a Phage International clinic in Tijuana, Mexico where we would treat resistant infections - primarily diabetic foot ulcers

and osteomyelitis. We had (and still have) located a very nice clinic in Tijuana, and also established the necessary relationships in Georgia required to perform phage sensitivity tests and receive sufficient quantities phages for treatment of our patients. We mistakenly believed that getting an import license and approval in Mexico would be the easy part. We halted that process, which has been ongoing for over a year, just before elections because, per our attorneys in Mexico City, the decision-makers at the Ministry of Health left their posts in order to run for office. So, we have been unable to open in Mexico, but continue to try to open new Phage Therapy Centers there and elsewhere. With your permission, I will post any announcements of future clinic openings.When the group from Phage International we went to Georgia for the first time, we met the owners of the Georgian clinic, Phage Therapy Center. Phage

Therapy Center was founded by one group from Eliava Institute and another from the Center for Medical Polymers and Biomaterials. The clinic was established to bring foreign patients into Georgia for treatment of chronic infections. This group quite obviously had the medical and scientific expertise but they were having a little trouble getting necessary investment, and better access to the Western markets. We decided that a merger was a great idea and, as I recall, this happened around January or February of 2005. We made the Phage Therapy Center a wholly-owned subsidiary. We opened a "Western Style" clinic in September of last year and since then, we have been treating both Georgian and foreign patients.Phage International now consists of three persons in the US who handle IT, marketing, and business development. In Georgia our stakeholders include eight PhD-level microbiologists; five PhD level chemists; a

physician, and two support individuals. Phage International is a US corporation that is privately held and privately funded; our investors include two US physicians and an entrepreneur from the Silicon Valley.The ClinicPhage Therapy Center has a new director, his name is Dr. Tengiz Chikvashvili. Dr. Chikvashvili has over 25 years of medical experience that includes extensive use of bacteriophages in his practice. The clinic is staffed with two physicians, a nurse, and a translator. Phage Therapy Center has also established a network of relationships with many specialists and professors at the medical universities in and around Tbilisi. Our network includes Dr. Guram Gvasalia, who is a professor at the State Medical University and teaches interns courses in the use of phages in surgical practice. Dr. Gvasalia is mentioned in many of Betty Kutter's papers, he's the surgeon featured in the White Pines

documentary "Killer Cure". Our goal is to establish Phage Therapy Centers, staffed with the best professional medical personnel who are trained in the use of phages, in a number of countries.Cost of TreatmentI don't want to post the price ranges here and would rather refer readers to the FAQ on the www.phagetherapycenter.com web site. The current URL is:www.phagetherapycenter.com/pii/PatientServlet?command=static_clinicfaqThe FAQ also contains the caveats and some of the conditions around the logistics of getting treatment; it includes the price ranges.Medical Conditions TreatedWe are getting excellent results treating the following conditions:- sinusitis / rhinitis;- ear infections;- urinary tract, kidney infections, cystitis;- intestinal infections;- infected wounds, diabetic ulcers and osteomyelitis;- surgical infections; and- chronic

prostatitis.Generally, if you have or suspect a bacterial infection it is very likely that we can treat it. We request a bacterial sample and medical records before you come for treatment; if you can't get a bacterial sample, the clinic will still accept you. Getting the sample has been very difficult for most patients; it is not a requirement, it just shortens your stay at the clinic. Here's why: phages are very narrow spectrum, they will only infect a single species and in many cases a specific strain of bacteria. The clinic uses phage cocktails, which are combinations of multiple species of phages. The commercial versions of these cocktails were developed by Eliava Institute, and they are "tuned" for the dominant clinically significant pathogens in the Caucasus region. What's clinically significant depends on where you live; in the US, this varies from state to state (for example, check out www.narsa.net and go

to their page on Clinical Relevant Strains: http://www.narsa.net/control/member/search?repositoryId=106). To determine what is going to work for the individual, the lab performs a "phage sensitivity test" – it is essentially an antibiogram that includes the commercial phage cocktail in the test. The test and evaluation of results takes around a week to complete. If your infection is sensitive to that commercial cocktail, and assuming your medical condition is treatable, then you are our patient. If the infection is resistant to the cocktail, and if you approve the extra costs involved, the lab will develop an autophage. Autophage development involves manually searching a massive library or "bank" of phages for ones that the infection is sensitive to. All of the phages in this bank have been through clinical trials, to verify that

they are safe to use on humans. Sometimes this development takes a couple of days; sometimes it takes a month or more – it depends on many variables. So, if you come to our clinic without having sent a sample, best case you'll need to stay an extra week; worst case, you'll have to stay quite a bit longer that the average ten to twelve days of therapy required for treatment of chronic infection. However, some very complex, resistant conditions can take as long as six weeks or more to complete treatment. A little over half of our foreign patients have infections that are resistant to this commercial preparation and require development of an autophage.Bacteria That We Target (Genus): - Staphyloccus;- Proteus;- E.coli;- Pseudomonas; - Enterococcus;- Shigella;- Klebsiella;- Salmonella; and- several others.We have also had success at treating Candida/yeasts, and recently several cases

of very resistant forms of Citrobacter. There are no bacteriophages in any of the phage banks for Citrobacter, and phages do not work with yeasts - they were both treated with other approved medications that are available only in Georgia. There is also a medication and proprietary treatment protocol for treating sinusitis that is only available at Phage Therapy Center Georgia. They are able to remove or reduce polyps without surgery and it apparently suppresses the symptoms for life (this requires 10 treatments; return in six months for another treatment; return again in 10 years for a final treatment). Phages or other medications, as necessary, are utilized to eliminate any infection. Most of our patients whose conditions caused migraines, fatigue, muscle aches and pains have claimed that these symptoms are eliminated during the first few days of therapy. In my opinion, Phage Therapy Center is the best

place in the world to get treatment for chronic bacterial infections. Thank you very much for the opportunity to write about our clinic, it is very much appreciated by all of us. Here are our web sites:www.phageinternational.comwww.phagetherapycenter.comI would be very pleased to answer any questions.Sincerely, , SVP and Founder

[Guest guest]

Again thanks for your information , The links with Lyme Candida & Autism are anecdotal as they must be at this stage ..As per my site the medical profession are clutching at straws as to an explanation of the explosive growth, two camps basically ..one blaming misdiagnosis in the past and the other a genetic fault ..both do not stand up to scrutiny ..

Anyway , If you read Dr Cranton paper [ex Harvard} an acknowledged expert on yeast http://drcranton.com/CFIDS.htm#CFIDS%20Paper

The first thing that that stands out is the title of his paper Chronic fatigue Immune Dysfunction Syndrome [CFIDS] His patients all have CF

Dr Andy here in the UK a CFS victim himself finds Spirochetes in the blood in everyone of his many CFS patients ...

ALL autistic children have a yeast dominant yeast dysbiosis [the doctors euphemistically call it bowel problems].plus lots of growth factor so not so much CF.

As a yeast victim myself I recognise the symptoms of autistic children as mainly yeast based...I now am symptomatic of Lyme !!!

I then read this article is autism a type of Lyme disease http://www.canlyme.com/autismlyme.html

looking at the strange statistics i find it hard to justify tick bites as the source of spirochetes ,

I then find that we host spirochetes as part of our normal flora ! http://arpa.allenpress.com/arpaonline/?request=get-document & doi=10.1043%2F1543-2165(2004)128%3C823:IS%3E2.0.CO%3B2

So as per my site .. altered conditions in the gut allowing normally reined in pathogens to escape causing a duel deep seated infections ..

The links are in the reference section on my site also click the bold text in the main site for a direct link..

-----Original Message-----From: infections [mailto:infections ]On Behalf Of publicspiritSent: 14 July 2006 16:25infections Subject: [infections] Re: Phage Therapy

, sorry that I can't answer either of your questions directly but here are some leads that might help:The Genesis Clinic in Tbilisi, Georgia is a Children's clinic. The physician that runs this clinic in the Didube district refuses to use antibiotics, he uses bacteriophages exclusively for treating bacterial infection. As I recall and there is a statistician on staff there. Here's their web site: http://www.genesis.org.ge/As for contacts in the UK, it is my understanding that a number of people are doing phage work at Warwick University and there is a commercial company, Novolytics (HQ is Coventry) that is also developing products.I read your web site last night. Very interesting. Can you please provide some references to research on Lyme and Candida and their relationship to autism? Autism is indeed epidemic in our area.>> Well, thanks for the detailed and in-depth reply ,fascinating stuff , I> haven't read the links yet I'll look forward to reading them over the next> week...Couple of questions , have you any health statistics from Georgia> that show clear benefits from the dosing at birth with Phage's. And have you> any contact details for the UK researches> Your remarks on gut flora and immunity rings a bell, Its the central them of> my web site .In the "Autism is an infectious disease" section one group of> pioneering researches [click Bacteroides Frgilis] have found that TH2 is our> default setting Immune system.TH1 [adaptive] response is entirely> attributable to our interaction with microbes. In short we depend entirely> on our symbiotic relationship with our microbial flora for good health ..> > http://www.yeast-candida-infections-uk.co.uk/>