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EN>EN difficult to manage

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The title of a presentation is : " Condition X de Difícil Manejo " , the latter

part of which simply means " difficult to manage/treat " .

I know I have seen one or more words or phrases used to communicate this

meaning in journal titles, but I cannot bring a satisfying standard phrase

to mind:

" A Difficult to manage case of Condition X "

" A Troublesome Conditoion X "

Problematic

I'm afraid I haven't seen a word of the paper itself, so I haven't any

further clues, but I was hoping someone might recall some phrase that is

used for such circumstances.

Thanks in advance,

Burns

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