Re: GWAS Study (genetic study on PSSD)

[Guest guest]

You can count on me

>

> It would in possible in theory to determine which genetic variations are

linked to PSSD. This could potentially help us identify the genes involved. I

don't think any major research institute will do such a study on their own for

some time.

>

>

> I have discovered that it may be possible for me to do a GWAS (Genome Wide

Association Study) with Do It Yourself Genomics

http://www.diygenomics.org/participate.php . I do not have enough training YET

to do this but I am currently working on genomics research and learning more

everyday. This group will help citizen groups to set up studies of their own.

It essentially could help us to do the research ourselves.

>

> If we were to do this I would need many PSSD suffers to get themselves

genotyped. I have got myself genotyped. It currently costs $200 with 23andMe

(23andMe.com) . You would then have to volunteer your data for the study.

>

> I see two things potentially coming out of it.

> 1) We may learn what genes are responsible for PSSD symptoms. This could

possibly help explain the disorder and MAY (I really cannot know) eventually

help lead to treatments.

>

> 2) It may allow us to determine the genetic basis such that others would not

take SSRIs if they were prone to developing PSSD.

>

> Right now I don't need commitment from anyone. I just want to see if there

are even close to enough people interested. We would need at least 100,

probably more people to participate for it to be effective.

>

> If you would be willing to get genotyped for such a study please reply and let

me know so I can know if its even worth my while looking into this with

DIYgenomics.

>

[Guest guest]

On me too!

> >

> > It would in possible in theory to determine which genetic variations are

linked to PSSD. This could potentially help us identify the genes involved. I

don't think any major research institute will do such a study on their own for

some time.

> >

> >

> > I have discovered that it may be possible for me to do a GWAS (Genome Wide

Association Study) with Do It Yourself Genomics

http://www.diygenomics.org/participate.php . I do not have enough training YET

to do this but I am currently working on genomics research and learning more

everyday. This group will help citizen groups to set up studies of their own.

It essentially could help us to do the research ourselves.

> >

> > If we were to do this I would need many PSSD suffers to get themselves

genotyped. I have got myself genotyped. It currently costs $200 with 23andMe

(23andMe.com) . You would then have to volunteer your data for the study.

> >

> > I see two things potentially coming out of it.

> > 1) We may learn what genes are responsible for PSSD symptoms. This could

possibly help explain the disorder and MAY (I really cannot know) eventually

help lead to treatments.

> >

> > 2) It may allow us to determine the genetic basis such that others would not

take SSRIs if they were prone to developing PSSD.

> >

> > Right now I don't need commitment from anyone. I just want to see if there

are even close to enough people interested. We would need at least 100,

probably more people to participate for it to be effective.

> >

> > If you would be willing to get genotyped for such a study please reply and

let me know so I can know if its even worth my while looking into this with

DIYgenomics.

> >

>

[Guest guest]

Hmm so we only have 2 so far! Seriously! So for everybody's talk about how they

wish people were researching PSSD, looking for a cure, etc only two people would

be willing to get genotyped. If I were to do this study it would be a lot of

work and we would need at least 100 people (probably more for proper statistical

analysis), somehow I don't think we are going to make it there.

I find this board interesting. I have been a member for two years now and all I

ever hear is sob stories and angry rants about the pharma industry. YES PSSD

SUCKS. YES PHARMA FUCKED US OVER. But doesn't anyone want to do something

about it? I posted on here about the personalized medicine conference too, but

all I heard was people pissed at Pharma. Come on guys. If we want the medical

community to help us we have to fight for it, and get involved with research,

and take a stand, not just bitch. Its okay to come here for sympathy, I have

definitely needed it before, but we should also try to organize for a cure.

I don't know if through a genome wide association study we will learn anything

that will help us or not, but that is the nature of science. I know if we don't

try and just sit on this board ranting we'll never get anywhere. Everyone should

take it upon themselves to at least contact someone either in the media, or a

doctor, or a researcher. No one is going to save us unless we do it ourselves.

Search for researchers doing Pharmacogenomics, and then contact them. They

might choose to study the SSRIs. We need to organize. I know its hard because

many of us still have some issues with depression, myself included, but we need

to do something.

>

> It would in possible in theory to determine which genetic variations are

linked to PSSD. This could potentially help us identify the genes involved. I

don't think any major research institute will do such a study on their own for

some time.

>

>

> I have discovered that it may be possible for me to do a GWAS (Genome Wide

Association Study) with Do It Yourself Genomics

http://www.diygenomics.org/participate.php . I do not have enough training YET

to do this but I am currently working on genomics research and learning more

everyday. This group will help citizen groups to set up studies of their own.

It essentially could help us to do the research ourselves.

>

> If we were to do this I would need many PSSD suffers to get themselves

genotyped. I have got myself genotyped. It currently costs $200 with 23andMe

(23andMe.com) . You would then have to volunteer your data for the study.

>

> I see two things potentially coming out of it.

> 1) We may learn what genes are responsible for PSSD symptoms. This could

possibly help explain the disorder and MAY (I really cannot know) eventually

help lead to treatments.

>

> 2) It may allow us to determine the genetic basis such that others would not

take SSRIs if they were prone to developing PSSD.

>

> Right now I don't need commitment from anyone. I just want to see if there

are even close to enough people interested. We would need at least 100,

probably more people to participate for it to be effective.

>

> If you would be willing to get genotyped for such a study please reply and let

me know so I can know if its even worth my while looking into this with

DIYgenomics.

>

[Guest guest]

Yes! PLEASE PARTICIPATE IN THIS STUDY!

I think 199 Dollars shouldn't be too much money if it leads eventually to a cure

one day!

> >

> > It would in possible in theory to determine which genetic variations are

linked to PSSD. This could potentially help us identify the genes involved. I

don't think any major research institute will do such a study on their own for

some time.

> >

> >

> > I have discovered that it may be possible for me to do a GWAS (Genome Wide

Association Study) with Do It Yourself Genomics

http://www.diygenomics.org/participate.php . I do not have enough training YET

to do this but I am currently working on genomics research and learning more

everyday. This group will help citizen groups to set up studies of their own.

It essentially could help us to do the research ourselves.

> >

> > If we were to do this I would need many PSSD suffers to get themselves

genotyped. I have got myself genotyped. It currently costs $200 with 23andMe

(23andMe.com) . You would then have to volunteer your data for the study.

> >

> > I see two things potentially coming out of it.

> > 1) We may learn what genes are responsible for PSSD symptoms. This could

possibly help explain the disorder and MAY (I really cannot know) eventually

help lead to treatments.

> >

> > 2) It may allow us to determine the genetic basis such that others would not

take SSRIs if they were prone to developing PSSD.

> >

> > Right now I don't need commitment from anyone. I just want to see if there

are even close to enough people interested. We would need at least 100,

probably more people to participate for it to be effective.

> >

> > If you would be willing to get genotyped for such a study please reply and

let me know so I can know if its even worth my while looking into this with

DIYgenomics.

> >

>

[Guest guest]

OK, I'm willing to give it a try although it sounds more like SF than real deal.....

Now you've got 3

Alfa

To: SSRIsex Sent: Fri, January 28, 2011 7:54:09 AMSubject: Re: GWAS Study (genetic study on PSSD)

Hmm so we only have 2 so far! Seriously! So for everybody's talk about how they wish people were researching PSSD, looking for a cure, etc only two people would be willing to get genotyped. If I were to do this study it would be a lot of work and we would need at least 100 people (probably more for proper statistical analysis), somehow I don't think we are going to make it there. I find this board interesting. I have been a member for two years now and all I ever hear is sob stories and angry rants about the pharma industry. YES PSSD SUCKS. YES PHARMA FUCKED US OVER. But doesn't anyone want to do something about it? I posted on here about the personalized medicine conference too, but all I heard was people pissed at Pharma. Come on guys. If we want the medical community to help us we have to fight for it, and get involved with research, and take a stand, not just bitch. Its okay to come here for sympathy, I have definitely needed it before,

but we should also try to organize for a cure. I don't know if through a genome wide association study we will learn anything that will help us or not, but that is the nature of science. I know if we don't try and just sit on this board ranting we'll never get anywhere. Everyone should take it upon themselves to at least contact someone either in the media, or a doctor, or a researcher. No one is going to save us unless we do it ourselves.Search for researchers doing Pharmacogenomics, and then contact them. They might choose to study the SSRIs. We need to organize. I know its hard because many of us still have some issues with depression, myself included, but we need to do something. >> It would in possible in theory to

determine which genetic variations are linked to PSSD. This could potentially help us identify the genes involved. I don't think any major research institute will do such a study on their own for some time. > > > I have discovered that it may be possible for me to do a GWAS (Genome Wide Association Study) with Do It Yourself Genomics http://www.diygenomics.org/participate.php . I do not have enough training YET to do this but I am currently working on genomics research and learning more everyday. This group will help citizen groups to set up studies of their own. It essentially could help us to do the research ourselves. > > If we were to do this I would need many PSSD suffers to get themselves genotyped. I have got myself genotyped. It currently costs $200 with 23andMe (23andMe.com) . You would then have to volunteer your data for the study. > > I see two

things potentially coming out of it.> 1) We may learn what genes are responsible for PSSD symptoms. This could possibly help explain the disorder and MAY (I really cannot know) eventually help lead to treatments. > > 2) It may allow us to determine the genetic basis such that others would not take SSRIs if they were prone to developing PSSD. > > Right now I don't need commitment from anyone. I just want to see if there are even close to enough people interested. We would need at least 100, probably more people to participate for it to be effective. > > If you would be willing to get genotyped for such a study please reply and let me know so I can know if its even worth my while looking into this with DIYgenomics.>

[Guest guest]

You can count me it.

H

> > >

> > > It would in possible in theory to determine which genetic variations are

linked to PSSD. This could potentially help us identify the genes involved. I

don't think any major research institute will do such a study on their own for

some time.

> > >

> > >

> > > I have discovered that it may be possible for me to do a GWAS (Genome Wide

Association Study) with Do It Yourself Genomics

http://www.diygenomics.org/participate.php . I do not have enough training YET

to do this but I am currently working on genomics research and learning more

everyday. This group will help citizen groups to set up studies of their own.

It essentially could help us to do the research ourselves.

> > >

> > > If we were to do this I would need many PSSD suffers to get themselves

genotyped. I have got myself genotyped. It currently costs $200 with 23andMe

(23andMe.com) . You would then have to volunteer your data for the study.

> > >

> > > I see two things potentially coming out of it.

> > > 1) We may learn what genes are responsible for PSSD symptoms. This could

possibly help explain the disorder and MAY (I really cannot know) eventually

help lead to treatments.

> > >

> > > 2) It may allow us to determine the genetic basis such that others would

not take SSRIs if they were prone to developing PSSD.

> > >

> > > Right now I don't need commitment from anyone. I just want to see if

there are even close to enough people interested. We would need at least 100,

probably more people to participate for it to be effective.

> > >

> > > If you would be willing to get genotyped for such a study please reply and

let me know so I can know if its even worth my while looking into this with

DIYgenomics.

> > >

> >

>

[Guest guest]

I think this sounds like something I'd be willing to try too.

> >

> > It would in possible in theory to determine which genetic variations are

linked

> >to PSSD. This could potentially help us identify the genes involved. I don't

> >think any major research institute will do such a study on their own for some

> >time.

> >

> >

> >

> > I have discovered that it may be possible for me to do a GWAS (Genome Wide

> >Association Study) with Do It Yourself Genomics

> >http://www.diygenomics.org/participate.php . I do not have enough training

YET

> >to do this but I am currently working on genomics research and learning more

> >everyday. This group will help citizen groups to set up studies of their own.

It

> >essentially could help us to do the research ourselves.

> >

> >

> > If we were to do this I would need many PSSD suffers to get themselves

> >genotyped. I have got myself genotyped. It currently costs $200 with 23andMe

> >(23andMe.com) . You would then have to volunteer your data for the study.

> >

> >

> > I see two things potentially coming out of it.

> > 1) We may learn what genes are responsible for PSSD symptoms. This could

> >possibly help explain the disorder and MAY (I really cannot know) eventually

> >help lead to treatments.

> >

> >

> > 2) It may allow us to determine the genetic basis such that others would not

> >take SSRIs if they were prone to developing PSSD.

> >

> >

> > Right now I don't need commitment from anyone. I just want to see if there

are

> >even close to enough people interested. We would need at least 100, probably

> >more people to participate for it to be effective.

> >

> >

> > If you would be willing to get genotyped for such a study please reply and

let

> >me know so I can know if its even worth my while looking into this with

> >DIYgenomics.

> >

>

[Guest guest]

I cannot promise anything. The hardest thing will be getting the numbers.

Usually these studies use about 1000 people with a condition and 1000 controls

or more. Basically you have to screen out the noise. If you compare lay 50

people there will be some genetic variants they have in common just by chance

that have nothing to do with the condition.

> > >

> > > It would in possible in theory to determine which genetic variations are

linked to PSSD. This could potentially help us identify the genes involved. I

don't think any major research institute will do such a study on their own for

some time.

> > >

> > >

> > > I have discovered that it may be possible for me to do a GWAS (Genome Wide

Association Study) with Do It Yourself Genomics

http://www.diygenomics.org/participate.php . I do not have enough training YET

to do this but I am currently working on genomics research and learning more

everyday. This group will help citizen groups to set up studies of their own.

It essentially could help us to do the research ourselves.

> > >

> > > If we were to do this I would need many PSSD suffers to get themselves

genotyped. I have got myself genotyped. It currently costs $200 with 23andMe

(23andMe.com) . You would then have to volunteer your data for the study.

> > >

> > > I see two things potentially coming out of it.

> > > 1) We may learn what genes are responsible for PSSD symptoms. This could

possibly help explain the disorder and MAY (I really cannot know) eventually

help lead to treatments.

> > >

> > > 2) It may allow us to determine the genetic basis such that others would

not take SSRIs if they were prone to developing PSSD.

> > >

> > > Right now I don't need commitment from anyone. I just want to see if

there are even close to enough people interested. We would need at least 100,

probably more people to participate for it to be effective.

> > >

> > > If you would be willing to get genotyped for such a study please reply and

let me know so I can know if its even worth my while looking into this with

DIYgenomics.

> > >

> >

>

[Guest guest]

You can count me in

>

> It would in possible in theory to determine which genetic variations are

linked to PSSD. This could potentially help us identify the genes involved. I

don't think any major research institute will do such a study on their own for

some time.

>

>

> I have discovered that it may be possible for me to do a GWAS (Genome Wide

Association Study) with Do It Yourself Genomics

http://www.diygenomics.org/participate.php . I do not have enough training YET

to do this but I am currently working on genomics research and learning more

everyday. This group will help citizen groups to set up studies of their own.

It essentially could help us to do the research ourselves.

>

> If we were to do this I would need many PSSD suffers to get themselves

genotyped. I have got myself genotyped. It currently costs $200 with 23andMe

(23andMe.com) . You would then have to volunteer your data for the study.

>

> I see two things potentially coming out of it.

> 1) We may learn what genes are responsible for PSSD symptoms. This could

possibly help explain the disorder and MAY (I really cannot know) eventually

help lead to treatments.

>

> 2) It may allow us to determine the genetic basis such that others would not

take SSRIs if they were prone to developing PSSD.

>

> Right now I don't need commitment from anyone. I just want to see if there

are even close to enough people interested. We would need at least 100,

probably more people to participate for it to be effective.

>

> If you would be willing to get genotyped for such a study please reply and let

me know so I can know if its even worth my while looking into this with

DIYgenomics.

>

[Guest guest]

Alright, I'll give it a try as well. Lets have a headcount first before going for it. If we dont get enough members to try this, then it probably doesn't make sense to do it. $200. Some of us spend that much every month on supplements!!Subject: Re: GWAS Study (genetic study on PSSD)To: SSRIsex Date: Saturday, January 29, 2011, 1:56 AM

I think this sounds like something I'd be willing to try too.

> >

> > It would in possible in theory to determine which genetic variations are linked

> >to PSSD. This could potentially help us identify the genes involved. I don't

> >think any major research institute will do such a study on their own for some

> >time.

> >

> >

> >

> > I have discovered that it may be possible for me to do a GWAS (Genome Wide

> >Association Study) with Do It Yourself Genomics

> >http://www.diygenomics.org/participate.php . I do not have enough training YET

> >to do this but I am currently working on genomics research and learning more

> >everyday. This group will help citizen groups to set up studies of their own. It

> >essentially could help us to do the research ourselves.

> >

> >

> > If we were to do this I would need many PSSD suffers to get themselves

> >genotyped. I have got myself genotyped. It currently costs $200 with 23andMe

> >(23andMe.com) . You would then have to volunteer your data for the study.

> >

> >

> > I see two things potentially coming out of it.

> > 1) We may learn what genes are responsible for PSSD symptoms. This could

> >possibly help explain the disorder and MAY (I really cannot know) eventually

> >help lead to treatments.

> >

> >

> > 2) It may allow us to determine the genetic basis such that others would not

> >take SSRIs if they were prone to developing PSSD.

> >

> >

> > Right now I don't need commitment from anyone. I just want to see if there are

> >even close to enough people interested. We would need at least 100, probably

> >more people to participate for it to be effective.

> >

> >

> > If you would be willing to get genotyped for such a study please reply and let

> >me know so I can know if its even worth my while looking into this with

> >DIYgenomics.

> >

>

[Guest guest]

Are you using us for your thesis here?AlfaTo: SSRIsex Sent: Sat, January 29, 2011 11:26:27 AMSubject: Re: GWAS Study (genetic study on PSSD)

I cannot promise anything. The hardest thing will be getting the numbers. Usually these studies use about 1000 people with a condition and 1000 controls or more. Basically you have to screen out the noise. If you compare lay 50 people there will be some genetic variants they have in common just by chance that have nothing to do with the condition.

> > >

> > > It would in possible in theory to determine which genetic variations are linked to PSSD. This could potentially help us identify the genes involved. I don't think any major research institute will do such a study on their own for some time.

> > >

> > >

> > > I have discovered that it may be possible for me to do a GWAS (Genome Wide Association Study) with Do It Yourself Genomics http://www.diygenomics.org/participate.php . I do not have enough training YET to do this but I am currently working on genomics research and learning more everyday. This group will help citizen groups to set up studies of their own. It essentially could help us to do the research ourselves.

> > >

> > > If we were to do this I would need many PSSD suffers to get themselves genotyped. I have got myself genotyped. It currently costs $200 with 23andMe (23andMe.com) . You would then have to volunteer your data for the study.

> > >

> > > I see two things potentially coming out of it.

> > > 1) We may learn what genes are responsible for PSSD symptoms. This could possibly help explain the disorder and MAY (I really cannot know) eventually help lead to treatments.

> > >

> > > 2) It may allow us to determine the genetic basis such that others would not take SSRIs if they were prone to developing PSSD.

> > >

> > > Right now I don't need commitment from anyone. I just want to see if there are even close to enough people interested. We would need at least 100, probably more people to participate for it to be effective.

> > >

> > > If you would be willing to get genotyped for such a study please reply and let me know so I can know if its even worth my while looking into this with DIYgenomics.

> > >

> >

>

[Guest guest]

Alfa: Sorry, I hope I understand you correctly...but if, I think this is an

idiotic assumption (sorry!). talked about his (our) condition here

several times, you can check this. And so I'm abolutely sure he wants to

contribute finding a cure for us. I think we should be thankful there is someone

qualified here who wants to explore this problem.

> > > >

> > > > It would in possible in theory to determine which genetic variations are

> >linked to PSSD. This could potentially help us identify the genes involved.

I

> >don't think any major research institute will do such a study on their own

for

> >some time.

> >

> > > >

> > > >

> > > > I have discovered that it may be possible for me to do a GWAS (Genome

Wide

> >Association Study) with Do It Yourself Genomics

> >http://www.diygenomics.org/participate.php . I do not have enough training

YET

> >to do this but I am currently working on genomics research and learning more

> >everyday. This group will help citizen groups to set up studies of their

own.

> >It essentially could help us to do the research ourselves.

> >

> > > >

> > > > If we were to do this I would need many PSSD suffers to get themselves

> >genotyped. I have got myself genotyped. It currently costs $200 with

23andMe

> >(23andMe.com) . You would then have to volunteer your data for the study.

> >

> > > >

> > > > I see two things potentially coming out of it.

> > > > 1) We may learn what genes are responsible for PSSD symptoms. This

could

> >possibly help explain the disorder and MAY (I really cannot know) eventually

> >help lead to treatments.

> >

> > > >

> > > > 2) It may allow us to determine the genetic basis such that others would

> >not take SSRIs if they were prone to developing PSSD.

> >

> > > >

> > > > Right now I don't need commitment from anyone. I just want to see if

there

> >are even close to enough people interested. We would need at least 100,

> >probably more people to participate for it to be effective.

> >

> > > >

> > > > If you would be willing to get genotyped for such a study please reply

and

> >let me know so I can know if its even worth my while looking into this with

> >DIYgenomics.

> > > >

> > >

> >

>

[Guest guest]

, that was just a simple question, no need for labeling it. I'm familiar with his posts and btw I also consented to participate in this research myself.I would like to hear what has to say though....AlfaTo: SSRIsex Sent: Sun, January 30, 2011 1:46:43 AMSubject: Re: GWAS Study (genetic study on PSSD)

Alfa: Sorry, I hope I understand you correctly...but if, I think this is an idiotic assumption (sorry!). talked about his (our) condition here several times, you can check this. And so I'm abolutely sure he wants to contribute finding a cure for us. I think we should be thankful there is someone qualified here who wants to explore this problem.

> > > >

> > > > It would in possible in theory to determine which genetic variations are

> >linked to PSSD. This could potentially help us identify the genes involved. I

> >don't think any major research institute will do such a study on their own for

> >some time.

> >

> > > >

> > > >

> > > > I have discovered that it may be possible for me to do a GWAS (Genome Wide

> >Association Study) with Do It Yourself Genomics

> >http://www.diygenomics.org/participate.php . I do not have enough training YET

> >to do this but I am currently working on genomics research and learning more

> >everyday. This group will help citizen groups to set up studies of their own.

> >It essentially could help us to do the research ourselves.

> >

> > > >

> > > > If we were to do this I would need many PSSD suffers to get themselves

> >genotyped. I have got myself genotyped. It currently costs $200 with 23andMe

> >(23andMe.com) . You would then have to volunteer your data for the study.

> >

> > > >

> > > > I see two things potentially coming out of it.

> > > > 1) We may learn what genes are responsible for PSSD symptoms. This could

> >possibly help explain the disorder and MAY (I really cannot know) eventually

> >help lead to treatments.

> >

> > > >

> > > > 2) It may allow us to determine the genetic basis such that others would

> >not take SSRIs if they were prone to developing PSSD.

> >

> > > >

> > > > Right now I don't need commitment from anyone. I just want to see if there

> >are even close to enough people interested. We would need at least 100,

> >probably more people to participate for it to be effective.

> >

> > > >

> > > > If you would be willing to get genotyped for such a study please reply and

> >let me know so I can know if its even worth my while looking into this with

> >DIYgenomics.

> > > >

> > >

> >

>

[Guest guest]

No I would not be using this for my thesis. I mostly hope to learn more so that

we may be able to figure out what causes this. However, I don't think we will

be able to get enough people to effectively do the study. Basically we would

need large numbers to screen out the noise. Basically we have 6 people now

including myself willing to do this. I would probably need the majority of the

PSSD membership to participate to get it done effectively.

I am trying to see if I can get 23andMe the company to do the study themselves.

If we could have them do it just based off people who had sexual side effects

while on SSRIs that might be enough so that we could learn something, even if

not all those people develop PSSD. I would be much happier if they did this

than if I did the study as they would probably have an easier time doing it.

Another company I spoke with was SureGene (www.suregene.net). They are working

on making a pharmacogenomic test for psychiatric drugs for schizophrenia. I

told them they should do one for SSRIs. Right now though they are a start up

with a limited budget so they are sticking to schizophrenia drugs.

> > > > >

> > > > > It would in possible in theory to determine which genetic variations

are

>

> > >linked to PSSD. This could potentially help us identify the genes

involved.

> >I

> >

> > >don't think any major research institute will do such a study on their own

for

> >

> > >some time.

> > >

> > > > >

> > > > >

> > > > > I have discovered that it may be possible for me to do a GWAS (Genome

> >Wide

> >

> > >Association Study) with Do It Yourself Genomics

> > >http://www.diygenomics.org/participate.php . I do not have enough training

> >YET

> >

> > >to do this but I am currently working on genomics research and learning

more

> > >everyday. This group will help citizen groups to set up studies of their

own.

> >

> > >It essentially could help us to do the research ourselves.

> > >

> > > > >

> > > > > If we were to do this I would need many PSSD suffers to get themselves

> > >genotyped. I have got myself genotyped. It currently costs $200 with

23andMe

> >

> > >(23andMe.com) . You would then have to volunteer your data for the study.

> > >

> > > > >

> > > > > I see two things potentially coming out of it.

> > > > > 1) We may learn what genes are responsible for PSSD symptoms. This

could

> >

> > >possibly help explain the disorder and MAY (I really cannot know)

eventually

> > >help lead to treatments.

> > >

> > > > >

> > > > > 2) It may allow us to determine the genetic basis such that others

would

>

> > >not take SSRIs if they were prone to developing PSSD.

> > >

> > > > >

> > > > > Right now I don't need commitment from anyone. I just want to see if

> >there

> >

> > >are even close to enough people interested. We would need at least 100,

> > >probably more people to participate for it to be effective.

> > >

> > > > >

> > > > > If you would be willing to get genotyped for such a study please reply

> >and

> >

> > >let me know so I can know if its even worth my while looking into this with

> > >DIYgenomics.

> > > > >

> > > >

> > >

> >

>

[Guest guest]

Ok, I got you wrong, sorry!

> > > > >

> > > > > It would in possible in theory to determine which genetic variations

are

>

> > >linked to PSSD. This could potentially help us identify the genes

involved.

> >I

> >

> > >don't think any major research institute will do such a study on their own

for

> >

> > >some time.

> > >

> > > > >

> > > > >

> > > > > I have discovered that it may be possible for me to do a GWAS (Genome

> >Wide

> >

> > >Association Study) with Do It Yourself Genomics

> > >http://www.diygenomics.org/participate.php . I do not have enough training

> >YET

> >

> > >to do this but I am currently working on genomics research and learning

more

> > >everyday. This group will help citizen groups to set up studies of their

own.

> >

> > >It essentially could help us to do the research ourselves.

> > >

> > > > >

> > > > > If we were to do this I would need many PSSD suffers to get themselves

> > >genotyped. I have got myself genotyped. It currently costs $200 with

23andMe

> >

> > >(23andMe.com) . You would then have to volunteer your data for the study.

> > >

> > > > >

> > > > > I see two things potentially coming out of it.

> > > > > 1) We may learn what genes are responsible for PSSD symptoms. This

could

> >

> > >possibly help explain the disorder and MAY (I really cannot know)

eventually

> > >help lead to treatments.

> > >

> > > > >

> > > > > 2) It may allow us to determine the genetic basis such that others

would

>

> > >not take SSRIs if they were prone to developing PSSD.

> > >

> > > > >

> > > > > Right now I don't need commitment from anyone. I just want to see if

> >there

> >

> > >are even close to enough people interested. We would need at least 100,

> > >probably more people to participate for it to be effective.

> > >

> > > > >

> > > > > If you would be willing to get genotyped for such a study please reply

> >and

> >

> > >let me know so I can know if its even worth my while looking into this with

> > >DIYgenomics.

> > > > >

> > > >

> > >

> >

>

[Guest guest]

I think we are still far from the numbers we would need to do a GWAS sadly.

There is probably just not enough people on here who are active members and

willing to be genotyped. Still, if you are interested please chime in.

If we can possibly get enough people it would be quite interesting. There is a

whole field of pharmacogenomics that is just starting up. It is quite exciting

to get to learn about all this stuff. I have spoken to a couple of professors

here about doing a study to study how drugs such as SSRIs and anitpsychotics

affect gene expression. It would need to be done in either a mouse model though

for that type of analysis (you cannot really biopsy human brain tissue for

example). But a GWAS is something that we could do if we get enough people.

Here is some information on GWAS for those who are interested. This is a fairly

short easy to understand question/answer document put up on the human genome

project website.

http://www.genome.gov/20019523

And here is a similar page on pharmacogenomics.

http://www.ornl.gov/sci/techresources/Human_Genome/medicine/pharma.shtml

If pharmacogenomics reached its full potential, most likely people wouldn't be

getting side effect issues like PSSD nearly as often as the doctor would be able

to tell them prior to taking a drug whether or not one would be a good candidate

(that is that one would respond well, and not have side effects).

23andMe and some of the other direct to consumer genotyping companies can tell

you some of this today. For example, I learned that I am predicted to be a poor

responder to SSRIs (surprise surprise, that was definitely true). Had I know

than before I took them I could have avoided taking them. I am also extra

sensitive to the blood thinner Warfarin used for stroke patients. With my

genetic data the doctor could know to give me a low dose. This could be life

saving.

Anyhow, even if we don't get enough people to do this study I at least encourage

you to look into it. Other companies include Navigenics, Lumigenix, and Decode

Me (just so you know I am not affiliated in any way with 23andMe, that just

happens to be the company I used for my genotyping). Its worth learning about

this stuff about this because genomics and medicine are going to become more

integrated in the near future and that will affect us all. I hear about it

every day. Being in grad school in genetics today is similar to what it must

have been like to be involved in the high tech/computer industry in the early

1980s. Things are just primed to take off, you can just feel it. Hopefully

someday all this new knowledge will help us cure PSSD as well! PSSD really does

suck. I have had ED issues for 4 years now and am just sick of it.

>

> > >

>

> > > It would in possible in theory to determine which genetic variations are

linked

>

> > >to PSSD. This could potentially help us identify the genes involved. I

don't

>

> > >think any major research institute will do such a study on their own for

some

>

> > >time.

>

> > >

>

> > >

>

> > >

>

> > > I have discovered that it may be possible for me to do a GWAS (Genome Wide

>

> > >Association Study) with Do It Yourself Genomics

>

> > >http://www.diygenomics.org/participate.php . I do not have enough training

YET

>

> > >to do this but I am currently working on genomics research and learning

more

>

> > >everyday. This group will help citizen groups to set up studies of their

own. It

>

> > >essentially could help us to do the research ourselves.

>

> > >

>

> > >

>

> > > If we were to do this I would need many PSSD suffers to get themselves

>

> > >genotyped. I have got myself genotyped. It currently costs $200 with

23andMe

>

> > >(23andMe.com) . You would then have to volunteer your data for the study.

>

> > >

>

> > >

>

> > > I see two things potentially coming out of it.

>

> > > 1) We may learn what genes are responsible for PSSD symptoms. This could

>

> > >possibly help explain the disorder and MAY (I really cannot know)

eventually

>

> > >help lead to treatments.

>

> > >

>

> > >

>

> > > 2) It may allow us to determine the genetic basis such that others would

not

>

> > >take SSRIs if they were prone to developing PSSD.

>

> > >

>

> > >

>

> > > Right now I don't need commitment from anyone. I just want to see if there

are

>

> > >even close to enough people interested. We would need at least 100,

probably

>

> > >more people to participate for it to be effective.

>

> > >

>

> > >

>

> > > If you would be willing to get genotyped for such a study please reply and

let

>

> > >me know so I can know if its even worth my while looking into this with

>

> > >DIYgenomics.

>

> > >

>

> >

>

[Guest guest]

Okay instead of doing my school work I have been working on this.

I found the following articles. It looks like people have already been trying

to work on SSRIs and pharmacogenomics.

http://ajp.psychiatryonline.org/cgi/content/abstract/167/12/1445

and

http://ajp.psychiatryonline.org/cgi/content/full/167/5/493

and

http://archpsyc.ama-assn.org/cgi/content/abstract/66/9/966

This isn't specifically PSSD but drug response to SSRIs. I emailed one of the

authors about doing a similar study on side effects of these drugs, not just the

responsiveness of the patients.

We'll see if I hear back or not.

> > > > > >

> > > > > > It would in possible in theory to determine which genetic variations

are

> >

> > > >linked to PSSD. This could potentially help us identify the genes

involved.

> > >I

> > >

> > > >don't think any major research institute will do such a study on their

own for

> > >

> > > >some time.

> > > >

> > > > > >

> > > > > >

> > > > > > I have discovered that it may be possible for me to do a GWAS

(Genome

> > >Wide

> > >

> > > >Association Study) with Do It Yourself Genomics

> > > >http://www.diygenomics.org/participate.php . I do not have enough

training

> > >YET

> > >

> > > >to do this but I am currently working on genomics research and learning

more

> > > >everyday. This group will help citizen groups to set up studies of their

own.

> > >

> > > >It essentially could help us to do the research ourselves.

> > > >

> > > > > >

> > > > > > If we were to do this I would need many PSSD suffers to get

themselves

> > > >genotyped. I have got myself genotyped. It currently costs $200 with

23andMe

> > >

> > > >(23andMe.com) . You would then have to volunteer your data for the

study.

> > > >

> > > > > >

> > > > > > I see two things potentially coming out of it.

> > > > > > 1) We may learn what genes are responsible for PSSD symptoms. This

could

> > >

> > > >possibly help explain the disorder and MAY (I really cannot know)

eventually

> > > >help lead to treatments.

> > > >

> > > > > >

> > > > > > 2) It may allow us to determine the genetic basis such that others

would

> >

> > > >not take SSRIs if they were prone to developing PSSD.

> > > >

> > > > > >

> > > > > > Right now I don't need commitment from anyone. I just want to see

if

> > >there

> > >

> > > >are even close to enough people interested. We would need at least 100,

> > > >probably more people to participate for it to be effective.

> > > >

> > > > > >

> > > > > > If you would be willing to get genotyped for such a study please

reply

> > >and

> > >

> > > >let me know so I can know if its even worth my while looking into this

with

> > > >DIYgenomics.

> > > > > >

> > > > >

> > > >

> > >

> >

>

[Guest guest]

Okay so 23andMe updated their database. However I don't know how well one SNP

(Single Nucleotide Polymorphism, basically genetic variant) is to predict this

type of stuff. I only had one copy of the risk allele for sexual dysfunction.

If you have 2 there is substantially higher odds or so they say. Of course I

had a very bad case of sexual disfunctions so go figure. Our understanding of

genetics is incomplete at this point of time. Likely there are other

contributing alleles. But this kind of research is happening now. I want

everyone to realize this. There is research going on in this area. Here is the

23andMe report:

Sexual dysfunction in response to SSRI antidepressant treatment

Journal Neuropsychopharmacology

Study Size

Replications None

Contrary Studies None

Applicable Ethnicities European

Marker rs6311

Anywhere from 20-70% of people taking a class of antidepressants called

selective serotonin reuptake inhibitors (SSRIs) experience sexual side effects.

In this study, researchers asked 81 people taking an SSRI (citalopram (Celexa),

escitalopram (Lexapro), fluoxetine (Prozac), paroxetine (Paxil), or sertraline

(Zoloft)) to take a self-administered survey about their sexual function. The

subjects in this study were neither clinically depressed nor anxious. Based on

adjusted scores from this survey, people with the CC genotype at rs6311 had 3.6

times greater odds of being categorized as having sexual dysfunction than people

with the CT or TT genotype.

Who Genotype What It Means

CC Substantially increased odds of sexual dysfunction while taking an SSRI for

depression.

**** *****CT Typical odds of sexual dysfunction while taking an SSRI

for depression.

TT Typical odds of sexual dysfunction while taking an SSRI for depression.

Citations

Bishop JR et al. (2006) . " Serotonin 2A -1438 G/A and G-protein Beta3 subunit

C825T polymorphisms in patients with depression and SSRI-associated sexual

side-effects. " Neuropsychopharmacology 31(10):2281-8.

> > > > > >

> > > > > > It would in possible in theory to determine which genetic variations

are

> >

> > > >linked to PSSD. This could potentially help us identify the genes

involved.

> > >I

> > >

> > > >don't think any major research institute will do such a study on their

own for

> > >

> > > >some time.

> > > >

> > > > > >

> > > > > >

> > > > > > I have discovered that it may be possible for me to do a GWAS

(Genome

> > >Wide

> > >

> > > >Association Study) with Do It Yourself Genomics

> > > >http://www.diygenomics.org/participate.php . I do not have enough

training

> > >YET

> > >

> > > >to do this but I am currently working on genomics research and learning

more

> > > >everyday. This group will help citizen groups to set up studies of their

own.

> > >

> > > >It essentially could help us to do the research ourselves.

> > > >

> > > > > >

> > > > > > If we were to do this I would need many PSSD suffers to get

themselves

> > > >genotyped. I have got myself genotyped. It currently costs $200 with

23andMe

> > >

> > > >(23andMe.com) . You would then have to volunteer your data for the

study.

> > > >

> > > > > >

> > > > > > I see two things potentially coming out of it.

> > > > > > 1) We may learn what genes are responsible for PSSD symptoms. This

could

> > >

> > > >possibly help explain the disorder and MAY (I really cannot know)

eventually

> > > >help lead to treatments.

> > > >

> > > > > >

> > > > > > 2) It may allow us to determine the genetic basis such that others

would

> >

> > > >not take SSRIs if they were prone to developing PSSD.

> > > >

> > > > > >

> > > > > > Right now I don't need commitment from anyone. I just want to see

if

> > >there

> > >

> > > >are even close to enough people interested. We would need at least 100,

> > > >probably more people to participate for it to be effective.

> > > >

> > > > > >

> > > > > > If you would be willing to get genotyped for such a study please

reply

> > >and

> > >

> > > >let me know so I can know if its even worth my while looking into this

with

> > > >DIYgenomics.

> > > > > >

> > > > >

> > > >

> > >

> >

>

[Guest guest]

having data from people suffering sexual dysfuctions WHILE they are on

antidepressant i think is quite useless for us, most of them recover when stop

drugs. Then, some people was affected by pssd after the second or the third

cycle of SSRI.

If u want 100 people with PSSD just contact admins of

http://www.paxilprogress.org/forums/ to send massive mails to members and inform

them about the study. Same thing should be done here by vornan. That's the only

way to have 100 PSSD sufferers, probably more.

> > > > > > >

> > > > > > > It would in possible in theory to determine which genetic

variations are

> > >

> > > > >linked to PSSD. This could potentially help us identify the genes

involved.

> > > >I

> > > >

> > > > >don't think any major research institute will do such a study on their

own for

> > > >

> > > > >some time.

> > > > >

> > > > > > >

> > > > > > >

> > > > > > > I have discovered that it may be possible for me to do a GWAS

(Genome

> > > >Wide

> > > >

> > > > >Association Study) with Do It Yourself Genomics

> > > > >http://www.diygenomics.org/participate.php . I do not have enough

training

> > > >YET

> > > >

> > > > >to do this but I am currently working on genomics research and learning

more

> > > > >everyday. This group will help citizen groups to set up studies of

their own.

> > > >

> > > > >It essentially could help us to do the research ourselves.

> > > > >

> > > > > > >

> > > > > > > If we were to do this I would need many PSSD suffers to get

themselves

> > > > >genotyped. I have got myself genotyped. It currently costs $200 with

23andMe

> > > >

> > > > >(23andMe.com) . You would then have to volunteer your data for the

study.

> > > > >

> > > > > > >

> > > > > > > I see two things potentially coming out of it.

> > > > > > > 1) We may learn what genes are responsible for PSSD symptoms.

This could

> > > >

> > > > >possibly help explain the disorder and MAY (I really cannot know)

eventually

> > > > >help lead to treatments.

> > > > >

> > > > > > >

> > > > > > > 2) It may allow us to determine the genetic basis such that others

would

> > >

> > > > >not take SSRIs if they were prone to developing PSSD.

> > > > >

> > > > > > >

> > > > > > > Right now I don't need commitment from anyone. I just want to see

if

> > > >there

> > > >

> > > > >are even close to enough people interested. We would need at least

100,

> > > > >probably more people to participate for it to be effective.

> > > > >

> > > > > > >

> > > > > > > If you would be willing to get genotyped for such a study please

reply

> > > >and

> > > >

> > > > >let me know so I can know if its even worth my while looking into this

with

> > > > >DIYgenomics.

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

[Guest guest]

I'll consider doing that.

> > > > > > > >

> > > > > > > > It would in possible in theory to determine which genetic

variations are

> > > >

> > > > > >linked to PSSD. This could potentially help us identify the genes

involved.

> > > > >I

> > > > >

> > > > > >don't think any major research institute will do such a study on

their own for

> > > > >

> > > > > >some time.

> > > > > >

> > > > > > > >

> > > > > > > >

> > > > > > > > I have discovered that it may be possible for me to do a GWAS

(Genome

> > > > >Wide

> > > > >

> > > > > >Association Study) with Do It Yourself Genomics

> > > > > >http://www.diygenomics.org/participate.php . I do not have enough

training

> > > > >YET

> > > > >

> > > > > >to do this but I am currently working on genomics research and

learning more

> > > > > >everyday. This group will help citizen groups to set up studies of

their own.

> > > > >

> > > > > >It essentially could help us to do the research ourselves.

> > > > > >

> > > > > > > >

> > > > > > > > If we were to do this I would need many PSSD suffers to get

themselves

> > > > > >genotyped. I have got myself genotyped. It currently costs $200

with 23andMe

> > > > >

> > > > > >(23andMe.com) . You would then have to volunteer your data for the

study.

> > > > > >

> > > > > > > >

> > > > > > > > I see two things potentially coming out of it.

> > > > > > > > 1) We may learn what genes are responsible for PSSD symptoms.

This could

> > > > >

> > > > > >possibly help explain the disorder and MAY (I really cannot know)

eventually

> > > > > >help lead to treatments.

> > > > > >

> > > > > > > >

> > > > > > > > 2) It may allow us to determine the genetic basis such that

others would

> > > >

> > > > > >not take SSRIs if they were prone to developing PSSD.

> > > > > >

> > > > > > > >

> > > > > > > > Right now I don't need commitment from anyone. I just want to

see if

> > > > >there

> > > > >

> > > > > >are even close to enough people interested. We would need at least

100,

> > > > > >probably more people to participate for it to be effective.

> > > > > >

> > > > > > > >

> > > > > > > > If you would be willing to get genotyped for such a study please

reply

> > > > >and

> > > > >

> > > > > >let me know so I can know if its even worth my while looking into

this with

> > > > > >DIYgenomics.

> > > > > > > >

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

[Guest guest]

This is also interesting to note. I have been doing more analysis on my

genotype. Effexor never did any good for me but did plenty of harm. I wish we

had genotyping stuff like this in 2007. If I had known I wouldn't have taken

it. I am 7X less likely to respond well to effexor than others.

Effexor

rs2032583(T;T)

Magnitude: 0

References:2

7x less likely to respond to certain antidepressants

....more...

(hide)

rs2032583 is a SNP in the ABCB1 gene (also known as the MDR1 gene), which

encodes a protein that transports certain molecules across the blood-brain

barrier. SNPs in ABCB1 may thus influence the intracerebral concentrations of

certain drugs and thus their efficacy or potential for adverse side effects.

rs2032583 is one of 9 SNPs found within a tight linkage block (r² >=

0.8 ) such that the minor allele at any one of them predicts (with ~80%+

accuracy) that the other SNPs will also be the minor allele. The list of the 9

SNPs is shown below. When treated for depression with substrates of the protein

encoded by ABCB1, carriers of one or two minor alleles at these ABCB1 SNPs have

been reported to respond better than non-carriers. The antidepressant drugs that

are know...