Guest guest Posted February 2, 2004 Report Share Posted February 2, 2004 Dear , Yes, youre right. Regards, > Dear , > I'm so sorry the SSKI didn't do the trick for Judi! Glad she is > doing better since stopping it! I have never heard the > expression " grand rounds " . Does that mean many doctors will put their > heads together to figure out her case? > Love, > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 3, 2004 Report Share Posted February 3, 2004 Hi , I am sorry that the sski didn't work..... I am not too sure how it works for me but then again I don't really know why I have EN and it certainly isn't the same as PG.... When they first put me on the sski the doc wrote the Rx wrong and gave me an overdose of it and I had similar reactions, like the rash and feeling so tired I couldn't keep my eyes open. I will keep Judi in my thoughts and my prayers..... > >Reply-To: erythema_nodosum_Group >To: erythema_nodosum_Group >Subject: Re: Mechanism of SSKI >Date: Tue, 03 Feb 2004 01:36:53 -0000 > > > >Hi , > >Judi did worse taking the SSKI. She stopped taking it a week after >she started. She seemed to get an additional rash that was flat in >appearance on the same area where she has her skin condition. In >addition to that she was so tired she couldnt keep her eyes open. >Her stomach was upset and she alternated between sweats and chills. >Her pulse rate went up to 90. Normal for her is about 70. I now >err on the side of caution since the Dapsone, so she stopped taking >it. Since then she seems to be doing better. > >I dont know how the stuff is supposed to work. Years ago they used >it as an expectorant. Since it didnt work for her, I cant be of >much help to you in explaining how it helps skin conditions. Part >of the answer could be the placebo effect. > >Her new doctor said her condition does not look like PG. She is >going to have " grand rounds " soon. > > >Regards, > > > > > > > Dear and Group, > > While searching for infor for I found some >interesting > > info on SSKI. This is what the Dermatology Online Journal (On our > > Links under Erythema nodosum) says about how it may work: > > " Potassium iodide in a dosage of 400 to 900 mg daily or a > > saturated solution of potassium iodide, 2 to 10 drops in water or > > orange juice three times per day, has been reported to be useful. >The > > mechanism of action of potassium iodide in erythema nodosum is > > unknown, but a theoretical mechanism involves its stimulation of > > heparin release from mast cells. Heparin acts to suppress delayed > > hypersensitivity reactions. The reported response in some patients > > with erythema nodosum lesions to heparinoid ointment under >occlusion > > supports this proposed mechanism of action On the other hand, > > potassium iodide also inhibits neutrophil chemotaxis. Potassium > > iodide is contraindicated during pregnancy, because it can produce >a > > goiter in the fetus. Severe hypothyroidism secondary to exogenous > > intake of iodide has been also described in patients with erythema > > nodosum treated with potassium iodide. " > > How is Judi doing on the SSKI? > > , I haven't found anything about the indents you > > experience. If I do find something I'll be sure to post it. It may >be > > a varient of EN. > > Love, > > > _________________________________________________________________ Check out the coupons and bargains on MSN Offers! http://shopping.msn.com/softcontent/softcontent.aspx?scmId=1418 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 3, 2004 Report Share Posted February 3, 2004 Hi , Thanks for your email. Judi's doctor is not sure what she has. Her present doctor does not think she has PG. Since it ulcerated in the beginning it probably isnt EN either. At this point I dont care what it is as long as she can get off the prednisone. Regards, > > > Dear and Group, > > > While searching for infor for I found some > >interesting > > > info on SSKI. This is what the Dermatology Online Journal (On our > > > Links under Erythema nodosum) says about how it may work: > > > " Potassium iodide in a dosage of 400 to 900 mg daily or a > > > saturated solution of potassium iodide, 2 to 10 drops in water or > > > orange juice three times per day, has been reported to be useful. > >The > > > mechanism of action of potassium iodide in erythema nodosum is > > > unknown, but a theoretical mechanism involves its stimulation of > > > heparin release from mast cells. Heparin acts to suppress delayed > > > hypersensitivity reactions. The reported response in some patients > > > with erythema nodosum lesions to heparinoid ointment under > >occlusion > > > supports this proposed mechanism of action On the other hand, > > > potassium iodide also inhibits neutrophil chemotaxis. Potassium > > > iodide is contraindicated during pregnancy, because it can produce > >a > > > goiter in the fetus. Severe hypothyroidism secondary to exogenous > > > intake of iodide has been also described in patients with erythema > > > nodosum treated with potassium iodide. " > > > How is Judi doing on the SSKI? > > > , I haven't found anything about the indents you > > > experience. If I do find something I'll be sure to post it. It may > >be > > > a varient of EN. > > > Love, > > > > > > > _________________________________________________________________ > Check out the coupons and bargains on MSN Offers! > http://shopping.msn.com/softcontent/softcontent.aspx?scmId=1418 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 3, 2004 Report Share Posted February 3, 2004 hi david, long time, no talk. your last sentence frightens me a little. what do you think of the new doc? maybe there is more to the story, but i know you know as well as i do, " looks " can be awfully deceiving. as you know, a biopsy sets it pretty straight forward. this is nothing to play around with as you know, and he says that? if it is treated as any other dx, all that will happen is continued suffering. the protocall is pretty straight forward on p.g. docs need to get " infection " out of their skulls (assuming, as in most cases, this is what is going thru his head). i would like to hear more about his dx and what he is basing it on. fyi, i have been to " clinic " and " grand rounds " at u of m. clinic is when about 50 medical students get together with all of the resident docs and come up with a dx and treatment plan for you. i have participated in 2 of those. grand rounds, i have done this twice also. this is when about 100 2nd year med students (in small groups) walk thru your exam room (all afternoon)and your primary doc is there too. your get to be a " guinea pig " as i call it. i call it being in the state of " guinea piggism " ! (jeff's coined phrase...lol). they ask lots of questions about dx, sx, rx and so forth. these activities really helped me learn so much about p.g. because........i ask lots of questions too! i hope judi gets better soon! jeff > > > Hi , > > Judi did worse taking the SSKI. She stopped taking it a week after > she started. She seemed to get an additional rash that was flat in > appearance on the same area where she has her skin condition. In > addition to that she was so tired she couldnt keep her eyes open. > Her stomach was upset and she alternated between sweats and chills. > Her pulse rate went up to 90. Normal for her is about 70. I now > err on the side of caution since the Dapsone, so she stopped taking > it. Since then she seems to be doing better. > > I dont know how the stuff is supposed to work. Years ago they used > it as an expectorant. Since it didnt work for her, I cant be of > much help to you in explaining how it helps skin conditions. Part > of the answer could be the placebo effect. > > Her new doctor said her condition does not look like PG. She is > going to have " grand rounds " soon. > > > Regards, > > > > Quote Link to comment Share on other sites More sharing options...
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