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Myostatin: biology and clinical relevance

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Mini Rev Med Chem. 2006 Jul;6(7):765-70.

Myostatin: biology and clinical relevance.

Carnac G, Ricaud S, Vernus B, Bonnieu A.

INRA, UMR 866-Differen-ciation Cellulaire et Croissance, 34060

Montpellier Cedex 1, France.

Myostatin is a negative regulator of muscle mass. Important advances in

our understanding of the complex biology of this factor have revealed

the therapeutic potential of antagonizing the myostatin pathway. Here

we present the rationale for evaluating anti-myostatin therapies in

human muscle-wasting disorders.

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