Green tea pain modulating effect in sciatic nerve chronic constriction injury ra

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Nutr Neurosci. 2006 Feb-Apr;9(1-2):41-7.

Green tea pain modulating effect in sciatic nerve chronic

constriction injury rat model.

Renno WM, Saleh F, Klepacek I, Al-Khaledi G, Ismael H, Asfar S.

Department of Anatomy, Faculty of Medicine, Health Sciences Centre,

University of Kuwait, Safat, Kuwait.

We investigated the effect of green tea (GT) in unilateral injury

(CCI) to the rat scaitic nerve. Five groups (n = 6 rats/group) sham

group: rats which underwent operation but with no ligation to the

scaitic nerve, and received tap water for two weeks before and for

five weeks after the surgery. Four experimental groups underwent CCI

to the right sciatic nerve, divided randomly as follows: group E were

given tap water throughout the study. Group B received GT before and

after CCI. Group C was given GT following CCI. Group D received GT

for two weeks prior to CCI. Groups which consumed GT showed

significant improvement in the toe spread (P < 0.001) and foot

positioning (P < 0.001) tests compared to the experimental control

group. In addition, these groups showed a significant decrease in the

behavioral mechanical hyperalgesia (P < 0.0001) and allodynia (P <

0.0002). Consumption of GT improves both reflexes and sensation which

are often affected in the course of peripheral neuropathy.