No mutation was detected in the LMNA gene among sporadic CMT patients

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Beijing Da Xue Xue Bao. 2006 Feb 18;38(1):78-9. Links

No mutation was detected in the LMNA gene among sporadic Charcot-

Marie-Tooth patients.

Song SJ, Zhang YZ, Chen B, Wang MJ, Wang YY, Zhang YJ, Yan M, Zhong N.

Peking University Center of Medical Genetics; Department of Medical

Genetics, School of Basic Medical Sciences, Peking University,

Beijing 100083, China.

OBJECTIVE:To intensively investigate sporadic CMT patients, we have

analyzed the LMNA gene in this study in a series of 32 unrelated CMT

patients.

METHODS: Twelve exons of the LMNA gene were amplified from genetomic

DNA. PCR products of each exon were analyzed by single strand

conformational polymorphism (SSCP).

RESULTS: No abnormal SSCP pattern, suggesting no mutation in our CMT

patients, was detected.

CONCLUSION: The CMT diseases resulted from the mutations of LMNA gene

were rare.