motichondrail disease,enzemes,matabolism,fatique,brain

[Guest guest]

(remember Trichathecene mycotoxin exposure effects are compared to

radiation exposure.)

(ROS) REATIVE OXYGEN SPECIES MEDIATES CELLULAR DAMAGE, EFFECTS OF

(GSH) HEPATOCELLULAR GLUTATHIONE,SURVIVAL AND INTEGRITY OF NUCLEAR

MITOCHONDRIAL DNA(mtDNA) IN HUMAN HEPATOBLASTOMA CELLS FROM RADIATION

EXPOSUREradiation resulted in a dose-dependent generation of

(ROS),accompanied by a decrease of (GSH).

depletion of (GSH) prior to radiation increased (ROS). depletion of

(GSH) bt radiation was apparent in different subcellular sites,

particularly significant in mitochondria. depleted (GSH) resulted in

DNA fragmentation and apoptosis. (GSH) cells were also reduced.

cellular (GSH) is a factor in deturmining intrinsic sensativity.mtDNA

displayed an increased loss of integrity and was potentiated by (GSH)

depletion in mitochandria.

CONCLUSION-GSH PLAYS A CRITIAL PROTECTIVE ROLE IN MAINTAINING NUCLEAR

AND mtDNA FUNCTIONAL INTEGRITY AND INTRINSIC SENSATIVITY.

GSH ay not be involved in DNA damage repairing but may relate to

modification of DNA damage dependent signaling.

..http://www.osti.gov/energycitations/product.biblio.jsp?

osti_id=20429033

OXIDATIVE STRESS, MITOCHANDRAIL DNA MUTATION,MITOCHONDRAIL

RESPIRATORY SYSTEM,BRAIN AND MATABOLISM,ENERGY AFFECTS,PREMATURE

AGING AND DEATH.

oxidative stress,mitochondrial DNA utation and impairent of

antioxidant enzymes in aging

<http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6WX0-

45BBXH5-5 & _user=10 & _handle=V-WA-A-W-AC-MsSAYWA-UUA-U-AAZACUBCDW-

AACEUYVBDW-AVCEAVCED-AC-U & _fmt=summary & _coverDate=12%2F31%

2F2001 & _rdoc=5 & _orig=browse & _srch=%23toc%237144%232001%23999879993%

23289330!

& _cdi=7144 & view=f & _acct=C000050221 & _version=1 & _urlVersion=0 & _userid=10

& md5=102474fef4f25226a4a58e6bb824d1d5>

reactive oxygen species and mitochondrial diseases

<http://www.medscape.com/medline/abstract/11735379>

MYCOTOXINS (I highly recomend reading this, goes into mycotoxins in

detail)

good coverage on T-mycotoxins

<http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=164220>

mycotoxins can be classified as

hepatotoxins,nephrotoxins,neurotoxins, immunotoxins and so forth.

cell biologests put them into generic groups such as

tetatogens,mutagens,carcinogens and allergens.

MYCOTOXICOSIS-can be acute or chronic. acute toxicity has rapid onst

and obivous responce, while chronic toxicity is characterized by low-

dose long term exposure resulting in cancers and other generally

irreversible effects.

<http://www.chronicfatiguesupport.com/library/showarticle.cfm/id/6679>

brain and heart

heart muscles have the greatest mitochondrial content of any tissue

in the body.

neurons have far less mitochondria and run out long before the heart.

mitochandrail diseases

<http://www.umdf.org/mito_info/genetics.aspx>

inherited mitochondrial disorders usually result in severe disease

with infantile onset.

sporadic cases- not all mitochandrail diseases are inherited

mitchondrail diseases

<http://www.tsbvi.edu/Outreach/seehear/spring02/mitochondrial.htm>

mitochandrail disorders

<http://www.neuro.wustl.edu/neuromuscular/mitosyn.html>

COX deiiciency-it is possible may be do to abnormal changes(

mutation) of mitochoundria(mtDNA)

<http://www.webmd.com/hw/raising_a_family/nord1088.asp>

..

carnitine deficiency

<http://www.emedicine.com/ped/byname/carnitine-deficiency.htm>

<http://www.moderntherapy.com/micronutrients.html>

<http://www.baylor.edu/biomedical_studies/index.php?id=18701>

<http://www.baylorhealth.edu/imd/support.htm>

matabolic disease disorders,tests

<http://www.baylorhealth.edu/imd/researchtests.htm>

<http://www.baylorhealth.edu/imd/researchtests/glutathione.htm>

(GSH)

<http://www.baylorhealth.edu/imd/clinicaltests/homocysteine.htm>

<http://www.baylorhealth.edu/imd/researchtests/monoamine.htm>

neurotransmitters

<http://www.baylorhealth.edu/imd/researchtests/hcmgene.htm>

(PCR) gene mutation