Re: Recent Break through test on OCD/ Glutamate signal carrier

[Guest guest]

Wow! This is really interesting. Thanks for sharing the info. If you

get answers to your questions, which are great ones by the way.

..Please pass that along too. I would be really interested in knowing too.

Thanks,

BJ

>

> Hi,

> I just finished reading a very interesting front page article from

the Fall

> OCD Newsletter published by the OC foundation. The article stated

that doctors

> Lu, Feng, Welch at Department of Neurobiology, Duke University,

reported that

> a scaffolding protein called Sapap3 is involved in synaptic

communication

> within basal ganglia. They reported that the disabling the

scaffolding protein

> leads to OCD-like behavior, but replacing the broken scaffolding

protein with a

> normal protein restores normal behavior. This is the first study of

its kind

> in which the authors have tested a number of leads that are linked

to the

> putative OCD pathology namely:

> 1. It involved the striatal -frontal circuit.

> 2. Glutamate mediated communications between striatum and frontal

cortex was

> disruptive.

> 3. It zeroed in on gluamate( signal carrier) instead of the

serotonin (signal

> modulator) mechanism.

> Where can you get this glutamate? How can you replace the broken

scaffolding

> with normal protein?

> What do you think about the results of this test stating that the

OCD problem

> is not solved with serotonin but with the " signal carrier glutamate?

> The Doctors referred to OCD as a " neural circuit disease " . I'm

telling my

> son who has suffered immensely with OCD that he can use the new

name -----It

> doesn't carry the OCD stigma.

> I am not sure who the doctors on this OCD website I should be

addressing my

> questions.Would someone please forward this to them?

> Thank you,

> Dana

>

>

>

> ************************************** See what's new at

http://www.aol.com

>

>

>

[Guest guest]

I have just looked all over the OCF web site and can't find the fall

newsletter, only the spring one. Anyone else been able to find it?

>

> Hi,

> I just finished reading a very interesting front page article from

the Fall

> OCD Newsletter published by the OC foundation. The article stated

that doctors

> Lu, Feng, Welch at Department of Neurobiology, Duke University,

reported that

> a scaffolding protein called Sapap3 is involved in synaptic

communication

> within basal ganglia. They reported that the disabling the

scaffolding protein

> leads to OCD-like behavior, but replacing the broken scaffolding

protein with a

> normal protein restores normal behavior. This is the first study of

its kind

> in which the authors have tested a number of leads that are linked

to the

> putative OCD pathology namely:

> 1. It involved the striatal -frontal circuit.

> 2. Glutamate mediated communications between striatum and frontal

cortex was

> disruptive.

> 3. It zeroed in on gluamate( signal carrier) instead of the

serotonin (signal

> modulator) mechanism.

> Where can you get this glutamate? How can you replace the broken

scaffolding

> with normal protein?

> What do you think about the results of this test stating that the

OCD problem

> is not solved with serotonin but with the " signal carrier

glutamate?

> The Doctors referred to OCD as a " neural circuit disease " . I'm

telling my

> son who has suffered immensely with OCD that he can use the new

name -----It

> doesn't carry the OCD stigma.

> I am not sure who the doctors on this OCD website I should be

addressing my

> questions.Would someone please forward this to them?

> Thank you,

> Dana

>

>

>

> ************************************** See what's new at

http://www.aol.com

>

>

>

[Guest guest]

This is interesting. I had my OCD daughter's neurotransmitter levels

tested last May. Her glutamate was extremely high. It was 150 when

the highest normal range is 35. At that time, we opted to go the

traditional SSRI route. That didn't work out for us so I took her to

an Environmental Physician/Psychiatrist and he was very interested in

her high glutamate level. I'm not sure what he will do about it

because he is re-running the test now. It looks to me like the

article doesn't say that you need more glutamate but just that

glutamate plays a part. Am I mis-reading this?

>

> Hi,

> I just finished reading a very interesting front page article from

the Fall

> OCD Newsletter published by the OC foundation. The article stated

that doctors

> Lu, Feng, Welch at Department of Neurobiology, Duke University,

reported that

> a scaffolding protein called Sapap3 is involved in synaptic

communication

> within basal ganglia. They reported that the disabling the

scaffolding protein

> leads to OCD-like behavior, but replacing the broken scaffolding

protein with a

> normal protein restores normal behavior. This is the first study of

its kind

> in which the authors have tested a number of leads that are linked

to the

> putative OCD pathology namely:

> 1. It involved the striatal -frontal circuit.

> 2. Glutamate mediated communications between striatum and frontal

cortex was

> disruptive.

> 3. It zeroed in on gluamate( signal carrier) instead of the

serotonin (signal

> modulator) mechanism.

> Where can you get this glutamate? How can you replace the broken

scaffolding

> with normal protein?

> What do you think about the results of this test stating that the

OCD problem

> is not solved with serotonin but with the " signal carrier

glutamate?

> The Doctors referred to OCD as a " neural circuit disease " . I'm

telling my

> son who has suffered immensely with OCD that he can use the new

name -----It

> doesn't carry the OCD stigma.

> I am not sure who the doctors on this OCD website I should be

addressing my

> questions.Would someone please forward this to them?

> Thank you,

> Dana

>

>

>

> ************************************** See what's new at

http://www.aol.com

>

>

>

[Guest guest]

This is interesting. I had my OCD daughter's neurotransmitter levels

tested last May. Her glutamate was extremely high. It was 150 when

the highest normal range is 35. At that time, we opted to go the

traditional SSRI route. That didn't work out for us so I took her to

an Environmental Physician/Psychiatrist and he was very interested in

her high glutamate level. I'm not sure what he will do about it

because he is re-running the test now. It looks to me like the

article doesn't say that you need more glutamate but just that

glutamate plays a part. Am I mis-reading this?

>

> Hi,

> I just finished reading a very interesting front page article from

the Fall

> OCD Newsletter published by the OC foundation. The article stated

that doctors

> Lu, Feng, Welch at Department of Neurobiology, Duke University,

reported that

> a scaffolding protein called Sapap3 is involved in synaptic

communication

> within basal ganglia. They reported that the disabling the

scaffolding protein

> leads to OCD-like behavior, but replacing the broken scaffolding

protein with a

> normal protein restores normal behavior. This is the first study of

its kind

> in which the authors have tested a number of leads that are linked

to the

> putative OCD pathology namely:

> 1. It involved the striatal -frontal circuit.

> 2. Glutamate mediated communications between striatum and frontal

cortex was

> disruptive.

> 3. It zeroed in on gluamate( signal carrier) instead of the

serotonin (signal

> modulator) mechanism.

> Where can you get this glutamate? How can you replace the broken

scaffolding

> with normal protein?

> What do you think about the results of this test stating that the

OCD problem

> is not solved with serotonin but with the " signal carrier

glutamate?

> The Doctors referred to OCD as a " neural circuit disease " . I'm

telling my

> son who has suffered immensely with OCD that he can use the new

name -----It

> doesn't carry the OCD stigma.

> I am not sure who the doctors on this OCD website I should be

addressing my

> questions.Would someone please forward this to them?

> Thank you,

> Dana

>

>

>

> ************************************** See what's new at

http://www.aol.com

>

>

>

[Guest guest]

From what I gather the issue is excessive glutamate. Antiglutamatergic drugs

are being developed and tested for several issues. I'm very curious about how

your Environmental Physician will suggest dealing with this. Please keep us

posted if you don't mind? Also, may I ask how the neurotransmitters were

tested? Thanks, Sat Nov 10, 2007 10:14 am (PST) This is

interesting. I had my OCD daughter's neurotransmitter levels

tested last May. Her glutamate was extremely high. It was 150 when

the highest normal range is 35. At that time, we opted to go the

traditional SSRI route. That didn't work out for us so I took her to

an Environmental Physician/Psychiatr ist and he was very interested in

her high glutamate level. I'm not sure what he will do about it

because he is re-running the test now. It looks to me like the

article doesn't say that you need more glutamate but just that

glutamate plays a part. Am I mis-reading this?

[Guest guest]

The neurotransmitter test was a urine test. I know this isn't generally

accepted by most doctors but the options that are accepted by most have not

worked for my daughter. I had it done last May by a Naturopath and it also

showed low noriepinephrine (?) and serotonin. She might have even said

glutamate was associated with OCD but wasn't specific about what to do about it

and we ended up going with a mainstream pdoc for a summer of SSRI trials. That

pdoc says this is cutting edge and is willing to work with the Environmental

Physician.

I do know one thing he is going to do is test for allergies. My daughter has

been tested by an allergist and nothing showed up but he says he has a more

accurate way to test. He is also doing a blood test for PANDAS, lead poisoning,

RA, a couple of amino acids, gluten antibodies, and I'm not sure what else.

I will post updates.

[Guest guest]

Really interesting information Dana, thanks. Please keep us posted.

bmk100@... wrote: Hi,

I just finished reading a very interesting front page article from the Fall

OCD Newsletter published by the OC foundation. The article stated that doctors

Lu, Feng, Welch at Department of Neurobiology, Duke University, reported that

a scaffolding protein called Sapap3 is involved in synaptic communication

within basal ganglia. They reported that the disabling the scaffolding protein

leads to OCD-like behavior, but replacing the broken scaffolding protein with a

normal protein restores normal behavior. This is the first study of its kind

in which the authors have tested a number of leads that are linked to the

putative OCD pathology namely:

1. It involved the striatal -frontal circuit.

2. Glutamate mediated communications between striatum and frontal cortex was

disruptive.

3. It zeroed in on gluamate( signal carrier) instead of the serotonin (signal

modulator) mechanism.

Where can you get this glutamate? How can you replace the broken scaffolding

with normal protein?

What do you think about the results of this test stating that the OCD problem

is not solved with serotonin but with the " signal carrier glutamate?

The Doctors referred to OCD as a " neural circuit disease " . I'm telling my

son who has suffered immensely with OCD that he can use the new name -----It

doesn't carry the OCD stigma.

I am not sure who the doctors on this OCD website I should be addressing my

questions.Would someone please forward this to them?

Thank you,

Dana

************************************** See what's new at http://www.aol.com

[Guest guest]

Really interesting information Dana, thanks. Please keep us posted.

bmk100@... wrote: Hi,

I just finished reading a very interesting front page article from the Fall

OCD Newsletter published by the OC foundation. The article stated that doctors

Lu, Feng, Welch at Department of Neurobiology, Duke University, reported that

a scaffolding protein called Sapap3 is involved in synaptic communication

within basal ganglia. They reported that the disabling the scaffolding protein

leads to OCD-like behavior, but replacing the broken scaffolding protein with a

normal protein restores normal behavior. This is the first study of its kind

in which the authors have tested a number of leads that are linked to the

putative OCD pathology namely:

1. It involved the striatal -frontal circuit.

2. Glutamate mediated communications between striatum and frontal cortex was

disruptive.

3. It zeroed in on gluamate( signal carrier) instead of the serotonin (signal

modulator) mechanism.

Where can you get this glutamate? How can you replace the broken scaffolding

with normal protein?

What do you think about the results of this test stating that the OCD problem

is not solved with serotonin but with the " signal carrier glutamate?

The Doctors referred to OCD as a " neural circuit disease " . I'm telling my

son who has suffered immensely with OCD that he can use the new name -----It

doesn't carry the OCD stigma.

I am not sure who the doctors on this OCD website I should be addressing my

questions.Would someone please forward this to them?

Thank you,

Dana

************************************** See what's new at http://www.aol.com