NATAP: Sleep Disorders Sign of Liver Disease/Cirrhosis

[Guest guest]

Sleep disorders and brain MRI as early indicators of subclinical hepatic encephalopathy

Hepatogastroenterology. 2006 Jan-Feb;53(67):51-4.

Velissaris D, Solomou E, Kalogeropoulos A, Georgiopoulou V, Thomopoulos C,

Karatza C.

Department of Internal Medicine, Patras University Hospital, Rion, Greece.

BACKGROUND/AIMS: Cirrhotic patients with hepatic encephalopathy have significant impairment of their daily activities. Sleep disturbances and increased signal on T1-weighted brain Magnetic Resonance Imaging (MRI) are commonly encountered in this clinical entity. The prevalence of these abnormalities in patients with subclinical encephalopathy is unknown.

METHODOLOGY: Sleep history and brain MRI were evaluated in 26 cirrhotic individuals with no evidence of encephalopathy. Thirteen patients without liver dysfunction or signs of neurological impairment served as a control group.

RESULTS:

Sleep disturbances were found in 24 of 26 cirrhotic patients (92.3%), whereas 18 of them (69.2%) had brain MRI abnormalities (p<0.05 by McNemar's test).

Among the control group, 1 of 13 patients had sleep disorders, whereas none exhibited abnormal MRI (both p<0.001 by chi2 compared to study group). Increased bilirubin and globulin levels, and decreased albumin levels were found to have a significant correlation to brain MRI abnormalities among cirrhotic patients.

CONCLUSIONS: Sleep disturbances are emerging as a sensitive sign of subclinical encephalopathy

in cirrhotic patients. A major role of brain MRI is also recognized, as abnormal images are highly prevalent in this clinical entity. Furthermore, the level of MRI abnormalities appears to be in concordance with the

abnormal liver function tests.

[Guest guest]

I have had sleeping problems for years. Now after HCV is gone my sleep is better but still a problem. This study might be right on the mark.

Jules Levin

http://www.NATAP.org

In a message dated 3/7/06 1:55:53 PM, kathy-boo@... writes:

This is very interesting..How many of us have problems sleeping??? I did before Transplant.. I also had hallucinations, heard voices the whole 9 yards..Kathy

[Guest guest]

This is very interesting..How many of us have problems sleeping??? I did before Transplant.. I also had hallucinations, heard voices the whole 9 yards..KathyJuLev@... wrote: Sleep disorders and brain MRI as early indicators of subclinical hepatic encephalopathyHepatogastroenterology. 2006 Jan-Feb;53(67):51-4.Velissaris D, Solomou E, Kalogeropoulos A, Georgiopoulou V, Thomopoulos C,Karatza C.Department of Internal Medicine, Patras University Hospital, Rion, Greece.BACKGROUND/AIMS: Cirrhotic patients with hepatic encephalopathy have significant impairment of their daily activities. Sleep disturbances and increased signal on T1-weighted

brain Magnetic Resonance Imaging (MRI) are commonly encountered in this clinical entity. The prevalence of these abnormalities in patients with subclinical encephalopathy is unknown.METHODOLOGY: Sleep history and brain MRI were evaluated in 26 cirrhotic individuals with no evidence of encephalopathy. Thirteen patients without liver dysfunction or signs of neurological impairment served as a control group. RESULTS: Sleep disturbances were found in 24 of 26 cirrhotic patients (92.3%), whereas 18 of them (69.2%) had brain MRI abnormalities (p<0.05 by McNemar's test). Among the control group, 1 of 13 patients had sleep disorders, whereas none exhibited abnormal MRI (both p<0.001 by chi2 compared to study group). Increased bilirubin and globulin levels, and decreased albumin levels were found to have a significant

correlation to brain MRI abnormalities among cirrhotic patients. CONCLUSIONS: Sleep disturbances are emerging as a sensitive sign of subclinical encephalopathyin cirrhotic patients. A major role of brain MRI is also recognized, as abnormal images are highly prevalent in this clinical entity. Furthermore, the level of MRI abnormalities appears to be in concordance with theabnormal liver function tests. Kathy Brunow

[Guest guest]

Hey Kath,

I have had sleeping problems for years now. I take a sleeping "cocktail" made up of 2 10Mg Sonata, 2 Klonopin and a Zyprexa and most nights I'm up 2 hours later. That is IF I can get to sleep.

I do have the day/night reversal action going on as well. I take Provigil 200Mg twice a day to deal with it.

Allan with 2 L's <yawn>

Fwd: NATAP: Sleep Disorders Sign of Liver Disease/Cirrhosis

This is very interesting..How many of us have problems sleeping??? I did before Transplant.. I also had hallucinations, heard voices the whole 9 yards..KathyJuLev@... wrote: Sleep disorders and brain MRI as early indicators of subclinical hepatic encephalopathyHepatogastroenterology. 2006 Jan-Feb;53(67):51-4.Velissaris D, Solomou E, Kalogeropoulos A, Georgiopoulou V, Thomopoulos C,Karatza C.Department of Internal Medicine, Patras University Hospital, Rion, Greece.BACKGROUND/AIMS: Cirrhotic patients with hepatic encephalopathy have significant impairment of their daily activities. Sleep disturbances and increased signal on T1-weighted brain Magnetic Resonance Imaging (MRI) are commonly encountered in this clinical entity. The prevalence of these abnormalities in patients with subclinical encephalopathy is unknown.METHODOLOGY: Sleep history and brain MRI were evaluated in 26 cirrhotic individuals with no evidence of encephalopathy. Thirteen patients without liver dysfunction or signs of neurological impairment served as a control group. RESULTS: Sleep disturbances were found in 24 of 26 cirrhotic patients (92.3%), whereas 18 of them (69.2%) had brain MRI abnormalities (p<0.05 by McNemar's test). Among the control group, 1 of 13 patients had sleep disorders, whereas none exhibited abnormal MRI (both p<0.001 by chi2 compared to study group). Increased bilirubin and globulin levels, and decreased albumin levels were found to have a significant correlation to brain MRI abnormalities among cirrhotic patients. CONCLUSIONS: Sleep disturbances are emerging as a sensitive sign of subclinical encephalopathyin cirrhotic patients. A major role of brain MRI is also recognized, as abnormal images are highly prevalent in this clinical entity. Furthermore, the level of MRI abnormalities appears to be in concordance with theabnormal liver function tests.

[Guest guest]

I do Boo dKathy Brunow <kathy-boo@...> wrote: This is very interesting..How many of us have problems sleeping??? I did before Transplant.. I also had hallucinations, heard voices the whole 9 yards..Kathy

Use Photomail to share photos without annoying attachments.

[Guest guest]

You must have a different definition for "Dummies" than the one I'm familiar with.

Love,DiLibra me, Domine, de morte aeternagraymarshall@...

NATAP: Sleep Disorders Sign of Liver Disease/Cirrhosis

Sleep disorders and brain MRI as early indicators of subclinical hepatic encephalopathyHepatogastroenterology. 2006 Jan-Feb;53(67):51-4.Velissaris D, Solomou E, Kalogeropoulos A, Georgiopoulou V, Thomopoulos C,Karatza C.Department of Internal Medicine, Patras University Hospital, Rion, Greece.BACKGROUND/AIMS: Cirrhotic patients with hepatic encephalopathy have significant impairment of their daily activities. Sleep disturbances and increased signal on T1-weighted brain Magnetic Resonance Imaging (MRI) are commonly encountered in this clinical entity. The prevalence of these abnormalities in patients with subclinical encephalopathy is unknown.METHODOLOGY: Sleep history and brain MRI were evaluated in 26 cirrhotic individuals with no evidence of encephalopathy. Thirteen patients without liver dysfunction or signs of neurological impairment served as a control group. RESULTS: Sleep disturbances were found in 24 of 26 cirrhotic patients (92.3%), whereas 18 of them (69.2%) had brain MRI abnormalities (p<0.05 by McNemar's test). Among the control group, 1 of 13 patients had sleep disorders, whereas none exhibited abnormal MRI (both p<0.001 by chi2 compared to study group). Increased bilirubin and globulin levels, and decreased albumin levels were found to have a significant correlation to brain MRI abnormalities among cirrhotic patients. CONCLUSIONS: Sleep disturbances are emerging as a sensitive sign of subclinical encephalopathyin cirrhotic patients. A major role of brain MRI is also recognized, as abnormal images are highly prevalent in this clinical entity. Furthermore, the level of MRI abnormalities appears to be in concordance with theabnormal liver function tests.

[Guest guest]

Before treatment I would have problems sleeping for maybe three days then I would crash.That would continue for about a month then I would get back to a normal sleep program with somehelp from sleeping pills.This would happen about every three months and last for a month.Now it happens of and on but not as bad as before treatment.

Gail

Fwd: NATAP: Sleep Disorders Sign of Liver Disease/Cirrhosis

This is very interesting..How many of us have problems sleeping??? I did before Transplant.. I also had hallucinations, heard voices the whole 9 yards..KathyJuLev@... wrote: Sleep disorders and brain MRI as early indicators of subclinical hepatic encephalopathyHepatogastroenterology. 2006 Jan-Feb;53(67):51-4.Velissaris D, Solomou E, Kalogeropoulos A, Georgiopoulou V, Thomopoulos C,Karatza C.Department of Internal Medicine, Patras University Hospital, Rion, Greece.BACKGROUND/AIMS: Cirrhotic patients with hepatic encephalopathy have significant impairment of their daily activities. Sleep disturbances and increased signal on T1-weighted brain Magnetic Resonance Imaging (MRI) are commonly encountered in this clinical entity. The prevalence of these abnormalities in patients with subclinical encephalopathy is unknown.METHODOLOGY: Sleep history and brain MRI were evaluated in 26 cirrhotic individuals with no evidence of encephalopathy. Thirteen patients without liver dysfunction or signs of neurological impairment served as a control group. RESULTS: Sleep disturbances were found in 24 of 26 cirrhotic patients (92.3%), whereas 18 of them (69.2%) had brain MRI abnormalities (p<0.05 by McNemar's test). Among the control group, 1 of 13 patients had sleep disorders, whereas none exhibited abnormal MRI (both p<0.001 by chi2 compared to study group). Increased bilirubin and globulin levels, and decreased albumin levels were found to have a significant correlation to brain MRI abnormalities among cirrhotic patients. CONCLUSIONS: Sleep disturbances are emerging as a sensitive sign of subclinical encephalopathyin cirrhotic patients. A major role of brain MRI is also recognized, as abnormal images are highly prevalent in this clinical entity. Furthermore, the level of MRI abnormalities appears to be in concordance with theabnormal liver function tests.

[Guest guest]

Danne when we first got our new landlords..We had the tenet from hell downs stair front apartment OK..She kept calling us telling us to turn the heat up.. Then calling the land lords telling them we were trying to roast her alive OK.. Well in my very confused state (remember I was ESLD) I kept telling them we had the thermostat on 172 OK.. Bruce had to educated them on ammonia levels etc..I was adamant About it Danne..I tryed climing out a window.. we live on second floor.. People in bushes were talking about me..Would get lost coming back from bath room..Kathy Boodannegrl <dannegrl2003@...> wrote: I do Boo dKathy Brunow <kathy-boo@...> wrote: This is very interesting..How many of us have problems sleeping??? I did before Transplant.. I also had hallucinations, heard voices the whole 9 yards..Kathy Kathy Brunow

[Guest guest]

They had me on Ambian before TP..Ambian was take 2 at HS and if they still don't work take 2 more..Of course it piled up on me.. Now I take 50mg Trazadone HS..Also a nice cup of Cesetail Seasoning Apple Cinnamon tea helps too. Doing great though know..KathyAllan W Anger Jr <allananger@...> wrote: Hey Kath, I have had sleeping problems for years now. I take a sleeping "cocktail" made up of 2 10Mg Sonata, 2 Klonopin and a Zyprexa and most nights I'm up 2 hours later. That is IF I can get to sleep. I do

have the day/night reversal action going on as well. I take Provigil 200Mg twice a day to deal with it. Allan with 2 L's <yawn> Fwd:

NATAP: Sleep Disorders Sign of Liver Disease/Cirrhosis This is very interesting..How many of us have problems sleeping??? I did before Transplant.. I also had hallucinations, heard voices the whole 9 yards..KathyJuLev@... wrote: Sleep disorders and brain MRI as early indicators of subclinical hepatic encephalopathyHepatogastroenterology. 2006 Jan-Feb;53(67):51-4.Velissaris D, Solomou E, Kalogeropoulos A, Georgiopoulou V, Thomopoulos C,Karatza C.Department of Internal Medicine, Patras University Hospital, Rion, Greece.BACKGROUND/AIMS: Cirrhotic

patients with hepatic encephalopathy have significant impairment of their daily activities. Sleep disturbances and increased signal on T1-weighted brain Magnetic Resonance Imaging (MRI) are commonly encountered in this clinical entity. The prevalence of these abnormalities in patients with subclinical encephalopathy is unknown.METHODOLOGY: Sleep history and brain MRI were evaluated in 26 cirrhotic individuals with no evidence of encephalopathy. Thirteen patients without liver dysfunction or signs of neurological impairment served as a control group. RESULTS: Sleep disturbances were found in 24 of 26 cirrhotic patients (92.3%), whereas 18 of them (69.2%) had brain MRI abnormalities (p<0.05 by McNemar's test). Among the control group, 1 of 13 patients had sleep disorders, whereas none exhibited abnormal MRI (both

p<0.001 by chi2 compared to study group). Increased bilirubin and globulin levels, and decreased albumin levels were found to have a significant correlation to brain MRI abnormalities among cirrhotic patients. CONCLUSIONS: Sleep disturbances are emerging as a sensitive sign of subclinical encephalopathyin cirrhotic patients. A major role of brain MRI is also recognized, as abnormal images are highly prevalent in this clinical entity. Furthermore, the level of MRI abnormalities appears to be in concordance with theabnormal liver function tests. Kathy Brunow

[Guest guest]

I have a LOT of trouble staying on a "normal" schedule, you know go to sleep at night wake up in the morning.

Love,DiLibra me, Domine, de morte aeternagraymarshall@...

Fwd: NATAP: Sleep Disorders Sign of Liver Disease/Cirrhosis

This is very interesting..How many of us have problems sleeping??? I did before Transplant.. I also had hallucinations, heard voices the whole 9 yards..KathyJuLev@... wrote: Sleep disorders and brain MRI as early indicators of subclinical hepatic encephalopathyHepatogastroenterology. 2006 Jan-Feb;53(67):51-4.Velissaris D, Solomou E, Kalogeropoulos A, Georgiopoulou V, Thomopoulos C,Karatza C.Department of Internal Medicine, Patras University Hospital, Rion, Greece.BACKGROUND/AIMS: Cirrhotic patients with hepatic encephalopathy have significant impairment of their daily activities. Sleep disturbances and increased signal on T1-weighted brain Magnetic Resonance Imaging (MRI) are commonly encountered in this clinical entity. The prevalence of these abnormalities in patients with subclinical encephalopathy is unknown.METHODOLOGY: Sleep history and brain MRI were evaluated in 26 cirrhotic individuals with no evidence of encephalopathy. Thirteen patients without liver dysfunction or signs of neurological impairment served as a control group. RESULTS: Sleep disturbances were found in 24 of 26 cirrhotic patients (92.3%), whereas 18 of them (69.2%) had brain MRI abnormalities (p<0.05 by McNemar's test). Among the control group, 1 of 13 patients had sleep disorders, whereas none exhibited abnormal MRI (both p<0.001 by chi2 compared to study group). Increased bilirubin and globulin levels, and decreased albumin levels were found to have a significant correlation to brain MRI abnormalities among cirrhotic patients. CONCLUSIONS: Sleep disturbances are emerging as a sensitive sign of subclinical encephalopathyin cirrhotic patients. A major role of brain MRI is also recognized, as abnormal images are highly prevalent in this clinical entity. Furthermore, the level of MRI abnormalities appears to be in concordance with theabnormal liver function tests.

[Guest guest]

Would get lost coming back from bath room ...

ME TOO! About half the time I just have to stop in the hall and figure out where the living room is (you can see the living room from the bathroom door). Stacey is checking my amonia and I see her again on the 23rd. Has anyone else heard of "Be In Charge"? I'm "pre-signed up", I won't be officially signed up until I start tx.

Love,DiLibra me, Domine, de morte aeternagraymarshall@...

Re: Fwd: NATAP: Sleep Disorders Sign of Liver Disease/Cirrhosis

Danne when we first got our new landlords..We had the tenet from hell downs stair front apartment OK..She kept calling us telling us to turn the heat up.. Then calling the land lords telling them we were trying to roast her alive OK.. Well in my very confused state (remember I was ESLD) I kept telling them we had the thermostat on 172 OK.. Bruce had to educated them on ammonia levels etc..I was adamant About it Danne..I tryed climing out a window.. we live on second floor.. People in bushes were talking about me..Would get lost coming back from bath room..Kathy Boodannegrl <dannegrl2003@...> wrote:

I do Boo

dKathy Brunow <kathy-boo@...> wrote:

This is very interesting..How many of us have problems sleeping??? I did before Transplant.. I also had hallucinations, heard voices the whole 9 yards..Kathy

Kathy Brunow

[Guest guest]

Have you tried "Bengal Spice", I DO love that!

Love,DiLibra me, Domine, de morte aeternagraymarshall@...

Fwd: NATAP: Sleep Disorders Sign of Liver Disease/Cirrhosis

This is very interesting..How many of us have problems sleeping??? I did before Transplant.. I also had hallucinations, heard voices the whole 9 yards..KathyJuLev@... wrote: Sleep disorders and brain MRI as early indicators of subclinical hepatic encephalopathyHepatogastroenterology. 2006 Jan-Feb;53(67):51-4.Velissaris D, Solomou E, Kalogeropoulos A, Georgiopoulou V, Thomopoulos C,Karatza C.Department of Internal Medicine, Patras University Hospital, Rion, Greece.BACKGROUND/AIMS: Cirrhotic patients with hepatic encephalopathy have significant impairment of their daily activities. Sleep disturbances and increased signal on T1-weighted brain Magnetic Resonance Imaging (MRI) are commonly encountered in this clinical entity. The prevalence of these abnormalities in patients with subclinical encephalopathy is unknown.METHODOLOGY: Sleep history and brain MRI were evaluated in 26 cirrhotic individuals with no evidence of encephalopathy. Thirteen patients without liver dysfunction or signs of neurological impairment served as a control group. RESULTS: Sleep disturbances were found in 24 of 26 cirrhotic patients (92.3%), whereas 18 of them (69.2%) had brain MRI abnormalities (p<0.05 by McNemar's test). Among the control group, 1 of 13 patients had sleep disorders, whereas none exhibited abnormal MRI (both p<0.001 by chi2 compared to study group). Increased bilirubin and globulin levels, and decreased albumin levels were found to have a significant correlation to brain MRI abnormalities among cirrhotic patients. CONCLUSIONS: Sleep disturbances are emerging as a sensitive sign of subclinical encephalopathyin cirrhotic patients. A major role of brain MRI is also recognized, as abnormal images are highly prevalent in this clinical entity. Furthermore, the level of MRI abnormalities appears to be in concordance with theabnormal liver function tests.

[Guest guest]

I am glad I didn't have all the fun you guys did.They already think I am crazy let alone me helusinating.

Gail

Re: Fwd: NATAP: Sleep Disorders Sign of Liver Disease/Cirrhosis

Danne when we first got our new landlords..We had the tenet from hell downs stair front apartment OK..She kept calling us telling us to turn the heat up.. Then calling the land lords telling them we were trying to roast her alive OK.. Well in my very confused state (remember I was ESLD) I kept telling them we had the thermostat on 172 OK.. Bruce had to educated them on ammonia levels etc..I was adamant About it Danne..I tryed climing out a window.. we live on second floor.. People in bushes were talking about me..Would get lost coming back from bath room..Kathy Boodannegrl <dannegrl2003@...> wrote:

I do Boo

dKathy Brunow <kathy-boo@...> wrote:

This is very interesting..How many of us have problems sleeping??? I did before Transplant.. I also had hallucinations, heard voices the whole 9 yards..Kathy

Kathy Brunow

[Guest guest]

Wow !!! You guys are lucky ! The most my doctor will give me is 1 mg lorazepam (ativan) I think part of it is the fact that I was an addict but that was 25 years ago for heaven's sake ! SuZieKathy Brunow <kathy-boo@...> wrote: They had me on Ambian before TP..Ambian was take 2 at HS and if they still don't work take 2 more..Of course it piled up on me.. Now I take 50mg Trazadone HS..Also a nice cup of Cesetail Seasoning Apple Cinnamon tea helps too. Doing great though know..KathyAllan W Anger Jr <allananger@...> wrote: Hey Kath, I have had sleeping problems for years now. I take a sleeping "cocktail" made up of 2 10Mg Sonata, 2 Klonopin and a Zyprexa and most nights I'm up 2 hours later. That is IF I can get to sleep. I do have the day/night reversal action going on as well. I take Provigil 200Mg twice a day to deal with it. Allan with 2 L's <yawn> Fwd: NATAP: Sleep Disorders Sign of Liver Disease/Cirrhosis This is very interesting..How many of us have problems sleeping??? I did before Transplant.. I also had hallucinations, heard voices the whole 9 yards..KathyJuLev@... wrote: Sleep disorders and brain MRI as early indicators of subclinical hepatic encephalopathyHepatogastroenterology. 2006 Jan-Feb;53(67):51-4.Velissaris D, Solomou E, Kalogeropoulos A, Georgiopoulou V, Thomopoulos C,Karatza C.Department of Internal Medicine, Patras University Hospital, Rion, Greece.BACKGROUND/AIMS: Cirrhotic patients with hepatic encephalopathy have significant impairment of their daily activities. Sleep disturbances and increased signal on T1-weighted brain Magnetic Resonance Imaging (MRI) are commonly encountered in this clinical entity. The prevalence of these abnormalities in patients with subclinical encephalopathy is unknown.METHODOLOGY: Sleep history and brain MRI were evaluated in 26 cirrhotic individuals with no evidence of encephalopathy. Thirteen patients

without liver dysfunction or signs of neurological impairment served as a control group. RESULTS: Sleep disturbances were found in 24 of 26 cirrhotic patients (92.3%), whereas 18 of them (69.2%) had brain MRI abnormalities (p<0.05 by McNemar's test). Among the control group, 1 of 13 patients had sleep disorders, whereas none exhibited abnormal MRI (both p<0.001 by chi2 compared to study group). Increased bilirubin and globulin levels, and decreased albumin levels were found to have a significant correlation to brain MRI abnormalities among cirrhotic patients. CONCLUSIONS: Sleep disturbances are emerging as a sensitive sign of subclinical encephalopathyin cirrhotic patients. A major role of brain MRI is also recognized, as abnormal images are highly prevalent in this clinical entity. Furthermore, the level of

MRI abnormalities appears to be in concordance with theabnormal liver function tests.

Next time I'm coming back as a cat

[Guest guest]

DONALD HAS SLEEPING PROBLEMS EVEN WITH MEDS KATdannegrl <dannegrl2003@...> wrote: I do Boo dKathy Brunow <kathy-boo@...> wrote: This is very interesting..How many of us have problems sleeping??? I did before Transplant.. I also had hallucinations, heard voices the whole 9 yards..Kathy Use Photomail to share photos without annoying attachments.

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