Re: Altered calcium homeostasis in autism-spectrum disorders: mitochondrial aspartate/glutamate carrier AGC1 [1 Attachment]

[Guest guest]

basically too much calcium enters neurons (in autism), causing mitochondrial dysfunction. (and other bad things ...)

Natasa

[Attachment(s) <#TopText> from Sally Eva included below]

Theresa Binstock posted this on ABMD and I saved it. I don't understand

it. We need Natasa to explain

Sally

Altered calcium homeostasis in autism-spectrum disorders:

evidence from biochemical and genetic studies of the

mitochondrial aspartate/glutamate carrier AGC1

L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager,

F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo,

C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci,

S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico

Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008;

doi:10.1038/mp.2008.63

Abstract <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>

Full Text <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>

PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>

Supplementary information

<http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>

..

[Guest guest]

basically too much calcium enters neurons (in autism), causing mitochondrial dysfunction. (and other bad things ...)

Natasa

[Attachment(s) <#TopText> from Sally Eva included below]

Theresa Binstock posted this on ABMD and I saved it. I don't understand

it. We need Natasa to explain

Sally

Altered calcium homeostasis in autism-spectrum disorders:

evidence from biochemical and genetic studies of the

mitochondrial aspartate/glutamate carrier AGC1

L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager,

F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo,

C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci,

S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico

Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008;

doi:10.1038/mp.2008.63

Abstract <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>

Full Text <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>

PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>

Supplementary information

<http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>

..

[Guest guest]

basically too much calcium enters neurons (in autism), causing mitochondrial dysfunction. (and other bad things ...)

Natasa

[Attachment(s) <#TopText> from Sally Eva included below]

Theresa Binstock posted this on ABMD and I saved it. I don't understand

it. We need Natasa to explain

Sally

Altered calcium homeostasis in autism-spectrum disorders:

evidence from biochemical and genetic studies of the

mitochondrial aspartate/glutamate carrier AGC1

L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager,

F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo,

C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci,

S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico

Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008;

doi:10.1038/mp.2008.63

Abstract <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>

Full Text <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>

PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>

Supplementary information

<http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>

..

[Guest guest]

That's interesting. I've just reached the conclusion that my son's calcium

levels were too low.

The authors are very careful to stress that autism is a heterogeneous condition

- with a lot of individual variation. So they could have found this in just

the sample they looked at, but it's different in others.

Sue

>

> >

> > basically too much calcium enters neurons (in autism), causing

mitochondrial

> > dysfunction. (and other bad things ...)

> >

> >

> > Natasa

> >

> >

> >

> >

> > [Attachment(s) <#TopText> from Sally Eva included below]

> >

> > Theresa Binstock posted this on ABMD and I saved it. I don't understand

> > it. We need Natasa to explain

> > Sally

> >

> > Altered calcium homeostasis in autism-spectrum disorders:

> > evidence from biochemical and genetic studies of the

> > mitochondrial aspartate/glutamate carrier AGC1

> >

> > L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager,

> > F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo,

> > C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci,

> > S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico

> >

> > Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008;

> > doi:10.1038/mp.2008.63

> >

> > Abstract <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>

> >

> > Full Text <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>

> >

> > PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>

> >

> > Supplementary information

> > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>

> >

> > .

> >

> >

> >

> >

> >

>

[Guest guest]

That's interesting. I've just reached the conclusion that my son's calcium

levels were too low.

The authors are very careful to stress that autism is a heterogeneous condition

- with a lot of individual variation. So they could have found this in just

the sample they looked at, but it's different in others.

Sue

>

> >

> > basically too much calcium enters neurons (in autism), causing

mitochondrial

> > dysfunction. (and other bad things ...)

> >

> >

> > Natasa

> >

> >

> >

> >

> > [Attachment(s) <#TopText> from Sally Eva included below]

> >

> > Theresa Binstock posted this on ABMD and I saved it. I don't understand

> > it. We need Natasa to explain

> > Sally

> >

> > Altered calcium homeostasis in autism-spectrum disorders:

> > evidence from biochemical and genetic studies of the

> > mitochondrial aspartate/glutamate carrier AGC1

> >

> > L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager,

> > F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo,

> > C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci,

> > S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico

> >

> > Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008;

> > doi:10.1038/mp.2008.63

> >

> > Abstract <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>

> >

> > Full Text <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>

> >

> > PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>

> >

> > Supplementary information

> > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>

> >

> > .

> >

> >

> >

> >

> >

>

[Guest guest]

That's interesting. I've just reached the conclusion that my son's calcium

levels were too low.

The authors are very careful to stress that autism is a heterogeneous condition

- with a lot of individual variation. So they could have found this in just

the sample they looked at, but it's different in others.

Sue

>

> >

> > basically too much calcium enters neurons (in autism), causing

mitochondrial

> > dysfunction. (and other bad things ...)

> >

> >

> > Natasa

> >

> >

> >

> >

> > [Attachment(s) <#TopText> from Sally Eva included below]

> >

> > Theresa Binstock posted this on ABMD and I saved it. I don't understand

> > it. We need Natasa to explain

> > Sally

> >

> > Altered calcium homeostasis in autism-spectrum disorders:

> > evidence from biochemical and genetic studies of the

> > mitochondrial aspartate/glutamate carrier AGC1

> >

> > L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager,

> > F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo,

> > C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci,

> > S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico

> >

> > Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008;

> > doi:10.1038/mp.2008.63

> >

> > Abstract <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>

> >

> > Full Text <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>

> >

> > PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>

> >

> > Supplementary information

> > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>

> >

> > .

> >

> >

> >

> >

> >

>

[Guest guest]

Hair mercury negatively correlates with calcium pump activity in human

term newborns and their mothers at delivery

http://www.ncbi.nlm.nih.gov/pubmed/18288328?itool=EntrezSystem2.PEntrez.Pubmed.P\

ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=2

<<Pb and Hg both independently correlate negatively with Ca pump

activity without any statistically significant interaction.>>

Sally Eva schrieb:

> [Attachment(s) <#TopText> from Sally Eva included below]

>

> Theresa Binstock posted this on ABMD and I saved it. I don't understand

> it. We need Natasa to explain

> Sally

>

> Altered calcium homeostasis in autism-spectrum disorders:

> evidence from biochemical and genetic studies of the

> mitochondrial aspartate/glutamate carrier AGC1

>

> L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager,

> F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo,

> C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci,

> S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico

>

> Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008;

> doi:10.1038/mp.2008.63

>

> Abstract <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html

> <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>>

>

> Full Text <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html

> <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>>

>

> PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf

> <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>>

>

> Supplementary information

> <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html

> <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>>

>

> .

>

>

> ------------------------------------------------------------------------

>

>

> No virus found in this incoming message.

> Checked by AVG - www.avg.com

> Version: 8.5.435 / Virus Database: 271.1.1/2687 - Release Date: 02/14/10

07:35:00

>

>

[Guest guest]

Negative relationships between erythrocyte Ca-pump activity and lead

levels in mothers and newborns

http://www.ncbi.nlm.nih.gov/pubmed/11191638?itool=EntrezSystem2.PEntrez.Pubmed.P\

ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=5

<<Lead poisoning induces hematological, gastrointestinal and

neurological dysfunctions. One of the potential mechanisms is the

inhibition of calcium-pump (Ca-pump), a transport protein.>>

Sally Eva schrieb:

> [Attachment(s) <#TopText> from Sally Eva included below]

>

> Theresa Binstock posted this on ABMD and I saved it. I don't understand

> it. We need Natasa to explain

> Sally

>

> Altered calcium homeostasis in autism-spectrum disorders:

> evidence from biochemical and genetic studies of the

> mitochondrial aspartate/glutamate carrier AGC1

>

> L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager,

> F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo,

> C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci,

> S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico

>

> Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008;

> doi:10.1038/mp.2008.63

>

> Abstract <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html

> <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>>

>

> Full Text <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html

> <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>>

>

> PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf

> <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>>

>

> Supplementary information

> <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html

> <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>>

>

> .

>

>

> ------------------------------------------------------------------------

>

>

> No virus found in this incoming message.

> Checked by AVG - www.avg.com

> Version: 8.5.435 / Virus Database: 271.1.1/2687 - Release Date: 02/14/10

07:35:00

>

>

[Guest guest]

Lead-calcium interactions in cellular lead toxicity.

http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.Pu\

bmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8

<<Pb2+ disturbs intracellular Ca2+ homeostasis.>>

Sally Eva schrieb:

> [Attachment(s) <#TopText> from Sally Eva included below]

>

> Theresa Binstock posted this on ABMD and I saved it. I don't understand

> it. We need Natasa to explain

> Sally

>

> Altered calcium homeostasis in autism-spectrum disorders:

> evidence from biochemical and genetic studies of the

> mitochondrial aspartate/glutamate carrier AGC1

>

> L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager,

> F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo,

> C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci,

> S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico

>

> Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008;

> doi:10.1038/mp.2008.63

>

> Abstract <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html

> <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>>

>

> Full Text <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html

> <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>>

>

> PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf

> <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>>

>

> Supplementary information

> <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html

> <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>>

>

> .

>

>

> ------------------------------------------------------------------------

>

>

> No virus found in this incoming message.

> Checked by AVG - www.avg.com

> Version: 8.5.435 / Virus Database: 271.1.1/2687 - Release Date: 02/14/10

07:35:00

>

>

[Guest guest]

Sorry, I don't understand what the significance of this might be.

Margaret

>

>

> Hair mercury negatively correlates with calcium pump activity in human

> term newborns and their mothers at delivery

>

>

>

http://www.ncbi.nlm.nih.gov/pubmed/18288328?itool=EntrezSystem2.PEntrez.Pubmed.P\

ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=2

> <<Pb and Hg both independently correlate negatively with Ca pump

> activity without any statistically significant interaction.>>

>

> Sally Eva schrieb:

> > [Attachment(s) <#TopText> from Sally Eva included below]

> >

> > Theresa Binstock posted this on ABMD and I saved it. I don't understand

> > it. We need Natasa to explain

> > Sally

> >

> > Altered calcium homeostasis in autism-spectrum disorders:

> > evidence from biochemical and genetic studies of the

> > mitochondrial aspartate/glutamate carrier AGC1

> >

> > L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager,

> > F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo,

> > C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci,

> > S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico

> >

> > Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008;

> > doi:10.1038/mp.2008.63

> >

> > Abstract <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html

> > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>>

> >

> > Full Text <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html

> > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>>

> >

> > PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf

> > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>>

> >

> > Supplementary information

> > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html

> > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>>

> >

> > .

> >

> >

> > ------------------------------------------------------------------------

> >

> >

> > No virus found in this incoming message.

> > Checked by AVG - www.avg.com

> > Version: 8.5.435 / Virus Database: 271.1.1/2687 - Release Date: 02/14/10

07:35:00

> >

> >

>

[Guest guest]

Ditto: I don't see what the significance might be.

Margaret

>

>

> Negative relationships between erythrocyte Ca-pump activity and lead

> levels in mothers and newborns

>

>

>

http://www.ncbi.nlm.nih.gov/pubmed/11191638?itool=EntrezSystem2.PEntrez.Pubmed.P\

ubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=5

> <<Lead poisoning induces hematological, gastrointestinal and

> neurological dysfunctions. One of the potential mechanisms is the

> inhibition of calcium-pump (Ca-pump), a transport protein.>>

>

> Sally Eva schrieb:

> > [Attachment(s) <#TopText> from Sally Eva included below]

> >

> > Theresa Binstock posted this on ABMD and I saved it. I don't understand

> > it. We need Natasa to explain

> > Sally

> >

> > Altered calcium homeostasis in autism-spectrum disorders:

> > evidence from biochemical and genetic studies of the

> > mitochondrial aspartate/glutamate carrier AGC1

> >

> > L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager,

> > F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo,

> > C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci,

> > S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico

> >

> > Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008;

> > doi:10.1038/mp.2008.63

> >

> > Abstract <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html

> > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>>

> >

> > Full Text <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html

> > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>>

> >

> > PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf

> > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>>

> >

> > Supplementary information

> > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html

> > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>>

> >

> > .

> >

> >

> > ------------------------------------------------------------------------

> >

> >

> > No virus found in this incoming message.

> > Checked by AVG - www.avg.com

> > Version: 8.5.435 / Virus Database: 271.1.1/2687 - Release Date: 02/14/10

07:35:00

> >

> >

>

[Guest guest]

Am I the only one who feels like giving up? I really would appreciate an

explanation rather than a set of links because I can't spend my life following

up everything.It would be helpful if every single member of the list didn't have

to reinvent the wheel for themselves - information overload is destructive and

we are all suffering from it. I've got massive problems with my son't education

and simply can't follow up these links. In fact I have read so much

contradictory information here over the years and seen so many fads come and go

that it is hard to have any faith in anything that's posted here any more, apart

from the most simple biomed approaches which might help a bit. What would be

helpful are clear explanations in layman's terms,please.

Does anyone else remember the promises for TD DMPS. Where are all the cures?

Margaret

>

>

> Lead-calcium interactions in cellular lead toxicity.

>

>

>

http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.Pu\

bmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8

> <<Pb2+ disturbs intracellular Ca2+ homeostasis.>>

>

> Sally Eva schrieb:

> > [Attachment(s) <#TopText> from Sally Eva included below]

> >

> > Theresa Binstock posted this on ABMD and I saved it. I don't understand

> > it. We need Natasa to explain

> > Sally

> >

> > Altered calcium homeostasis in autism-spectrum disorders:

> > evidence from biochemical and genetic studies of the

> > mitochondrial aspartate/glutamate carrier AGC1

> >

> > L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager,

> > F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo,

> > C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci,

> > S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico

> >

> > Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008;

> > doi:10.1038/mp.2008.63

> >

> > Abstract <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html

> > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>>

> >

> > Full Text <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html

> > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>>

> >

> > PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf

> > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>>

> >

> > Supplementary information

> > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html

> > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>>

> >

> > .

> >

> >

> > ------------------------------------------------------------------------

> >

> >

> > No virus found in this incoming message.

> > Checked by AVG - www.avg.com

> > Version: 8.5.435 / Virus Database: 271.1.1/2687 - Release Date: 02/14/10

07:35:00

> >

> >

>

[Guest guest]

Hi Margaret,

IMO, lead is a problem for most kids in the UK, ASD or not. There are no safe

levels of lead. My asd son, who is my third child, has lead issues, partly

because of me (stripping lead paint, bathing in lead gas as a kid, etc) as

mothers pass on lead burdens (among others). My first born, NT, has lead

problems even though his detox systems are working pretty well.

I personally think the only way to remove lead from kids like ours is with DMSA.

The problem with our kids and other methods is that our kids are broken. Our

bodies generally have many back-up systems for attacking issues like toxicity;

however, these systems are often broken by things like bolus doses of hg, low

zinc levels, et. What that means is that for a kid like my youngest, who really

wasn't exposed to that much toxix metals compared to other kids, is incredibly

toxic in almost any metal you'd care to mention. He keeps all of them, so even

the smallest exposure is dangerous to him.

We chelate with DMSA (and ALA) on the Cutler protocol and as that lead is being

removed I want to ensure that in the bones and teeth calcium is replacing it.

We supplement only 300 mgs of calcium a day. Not very much but as I said,

problems if we don't do that. I also give ds milk products (kefir, yogurt) and

am a big believer in broths (being a colloidal suspension the minerals in them

are easy to absorb). Also, d3 and k2 are an important part of rebuilding ds.

I know what you mean about cures and grand promises. It's hard not to get

swept up in the latest thing, especially when a parent or two posts some

miraculous turnaround. I know that unless my son is chelated properly, most of

his problems won't stand a chance of being resolved. Even with proper chelation

though, he's obviously going to need something(s) more. It's hard to follow up

on what that something more would mean, beyond what we've done already.

I hope some of this might help.

Anita

> >

> >

> > Lead-calcium interactions in cellular lead toxicity.

> >

> >

> >

http://www.ncbi.nlm.nih.gov/pubmed/8247414?itool=EntrezSystem2.PEntrez.Pubmed.Pu\

bmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=8

> > <<Pb2+ disturbs intracellular Ca2+ homeostasis.>>

> >

> > Sally Eva schrieb:

> > > [Attachment(s) <#TopText> from Sally Eva included below]

> > >

> > > Theresa Binstock posted this on ABMD and I saved it. I don't understand

> > > it. We need Natasa to explain

> > > Sally

> > >

> > > Altered calcium homeostasis in autism-spectrum disorders:

> > > evidence from biochemical and genetic studies of the

> > > mitochondrial aspartate/glutamate carrier AGC1

> > >

> > > L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager,

> > > F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo,

> > > C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci,

> > > S Puglisi-Allegra, K-L " Tiny " Reichelt and A M Persico

> > >

> > > Mol Psychiatry 15: 38-52; advance online publication, July 8, 2008;

> > > doi:10.1038/mp.2008.63

> > >

> > > Abstract <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html

> > > <http://www.nature.com/mp/journal/v15/n1/abs/mp200863a.html>>

> > >

> > > Full Text <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html

> > > <http://www.nature.com/mp/journal/v15/n1/full/mp200863a.html>>

> > >

> > > PDF <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf

> > > <http://www.nature.com/mp/journal/v15/n1/pdf/mp200863a.pdf>>

> > >

> > > Supplementary information

> > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html

> > > <http://www.nature.com/mp/journal/v15/n1/suppinfo/mp200863s1.html>>

> > >

> > > .

> > >

> > >

> > > ------------------------------------------------------------------------

> > >

> > >

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07:35:00

> > >

> > >

> >

>