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HPV vaccine

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Human papilloma virus (HPV) is the virus that causes genital warts. Certain types of HPV cause cervical and anal cancer.

Despite potent antiretroviral therapy people with HIV continue to develop these cancers, partly because people seem to be more vulnerable to them with only modest levels of immune suppression.

Two vaccines to protect against infection with HPV are being approved around the world, but it is not known how well these will protect against the development of anal or cervical cancer in people with HIV.

Australian researchers told the IAS conference about tests of another vaccine designed to prevent the development of cancer in people who already have HPV. They tested it in HIV-positive gay men and found it was safe, with good immune responses to the vaccine despite a history of severe immune system damage. However, there were no clear trends in HPV detectability or anal cell changes when comparing the different vaccine doses and placebo.

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