Yasko's on VIRUSES in autism was:(NATASA or yasko experts)

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Probably 'cos you have to join the forum first. If you go to her site

and open parents forum it should tell you what to do. Then try that link

again or go to the forum and type few words in the search engine,

putting AND between those keywords. Or spend some time browsing through

the welcome/basic/intro section...

www.autismanswer.com

Natasa

here something from that forum that I liked and saved earlier:

DR AMY ON VIRUSES

I do believe that all of the children have viral issues. As discussed in

the Metals, microbes and methylation talks (this is now part of the

autism

starter kit) I believe that genetic weaknesses in the methylation

pathway

predispose to chronic viral infection. The viruses are able to trigger

host MT proteins, which can lead to the viruses helping to sequester

metals in the body. For some children we are able to get at these metals

simply by chelation. For other children we need to support the body to

deal with the viruses in order to see excretion of metals.

I do believe that TD DMPS does have activity to help to deal with viral

infection. I also think that you can use other herbs to support the body

during this time. The ones that you mentioned may be helpful. Where I do

not use TD DMPS in my practice I cannot really advise you on using these

herbs in conjunction with the TD DMPS. I do know that there are a number

of parents on this chat room who have used other products to support

viral

excretion along with the TD DMPS and they may be in a better position to

share their experiences with you. I have used monolaurin in my practice,

which is similar to lauricidin. I find that children who have the CBS up

regulation have more difficulty with this product. If your child is

older,

or quite apraxic, you may consider that he does have the CBS

upregulation,

in which case the use of monolaurin (or similar) may not be ideal.

....there are several types of viruses. Two of the

basic groups are DNA viruses and RNA viruses. The difference between

these

two groups is the form in which their genetic information is contained.

For RNA viruses, the genetic information is in the form of RNA. For DNA

based viruses it is as DNA.

Herpes is a DNA based virus. CMV, EBV, hepatitis are all DNA viruses.

Measles, mumps and rubella are RNA based viruses.

Our own genetic information is stored as DNA. The information that is

used

from the DNA is what is made into RNA. One way to think about it, is

that

DNA is all of the stock in the warehouse, and RNA is what you actually

buy

to use. The analogy that I use in talks, and in the RNA book (which

describes DNA and RNA more slowly so you can really understand it

better)

is my " home depot " example. DNA is all the wood, nails, screws etc on

the

shelves of home depot. RNA is the building materials you need for a

particular job, let's say to build your house, and then the completed

project that you can see, the house itself, is the protein.

So, to get back to the main point, our genetic material (all of our

information) is stored as DNA. When we are infected with a DNA based

virus

like herpes, it can multiply which is what we see as active infection or

outbreaks. Or, it can be latent. When it is latent it is sitting inside

our DNA in our cells. If you think of our DNA as one long pearl

necklace.

Then imagine cutting the string that holds the beads. Now insert some

colored beads in the middle of your pearl necklace. Now rejoin the

necklace. We now have a pearl necklace with a group of red beads in the

middle of the pearls. The red beads can just sit there until conditions

are such that the red beads can pop back out, leaving the pearls as they

were initially. The red beads can now multiply and cause active

infection.

Some of these red beads, AKA herpes that are now active can create

symptoms, some can pop back into the pearl necklace of our DNA.

When the virus pops out of the DNA to go from a latent form to an active

form it needs to multiply. In order to multiply it needs to make more of

its own DNA. There are four building blocks for DNA (again explained in

much more easy to understand detail in the RNA book). The way valtrex

works is to replace one of these four building blocks for DNA. The

building block provided by valtrex is altered so that it interferes with

the process for linking the beads together to make more virus.

So, valtrex actually interferes with viral replication. It does not

suppress the virus.

In order for valtrex to work, the virus needs to be actively

replicating.

If it is not replicating, if it is still stuck in the form of red beads

within the pearl necklace, the valtrex cannot act.

Recent work (Nature Reviews in Drug Discovery Nov 2005) in the field of

HIV research (HIV also integrates into our DNA) has shown that the most

effective way to treat this type of virus is to activate the latent

virus,

that virus which is still inside the pearl necklace, as well as to

interfere with its ability to multiply.

Bottom line, using several different types of antiviral agents at the

same

time that work via different mechanisms is more effective than using a

single antiviral agent.

Valtrex can only interfere with replication of viruses that use DNA

building blocks. This would include DNA based viruses, but not RNA based

viruses. Valtrex can interfere with herpes viral replication, but not so

for measles, mumps and rubella.

Measles, mumps and rubella are RNA based viruses. Measles and mumps are

retroviruses, which means that they can reverse their RNA, back to DNA,

and then they are able to get stuck inside our pearl necklaces. Then

when

they are ready to multiply again, the red beads pop out of our DNA, and

turn back into RNA to make more viral RNA.

While rubella is not a retrovirus, in other words it does not have the

equipment to reverse its RNA into DNA, it is able to borrow this

equipment

from measles and mumps. So in the presence of other retroviruses,

rubella

can act like a retrovirus.

Once viral DNA is integrated into our DNA, so once the red beads are

part

of our pearl necklace, the viral DNA can be copied when our DNA is

copied.

The way that the viral DNA is silenced, so that it is not active is by

methyl groups. The body recognizes DNA that is not our own, DNA that is

foreign, and it puts methyl groups on it to keep it quiet. If we have

methylation cycle mutations we cannot do this properly.

The longer that the methylation cycle is not working properly, the more

virus that can build up. That is why the viral load is higher in older

children, and why it can take longer to clear the virus. We need to get

the virus to pop out of our DNA, and then we need to squash it once it

is

in an active, replicative form. Evidence of the virus coming out of

hiding, out of our pearl necklace is seen as rashes, fever, headaches,

vomiting, etc. I believe that elevated creatinine is also a sign of

virus

coming out of hiding.

The role of methylation in viral silencing is another reason why I am

stressing the need for nutrigenomic testing for the methylation pathway

for all children. As you know I believe that virus helps to hold onto

metals in the body. Once you eradicate the virus, the metals will be

excreted. The longer the virus has been in the body, the more difficult

to

get to these metals. Once we have seen the release of metals, we still

need to think about chronic viral infection. That is why it is important

to be sure that methylation is working properly even for those children

who have recovered using other means to cause metal excretion. As I have

mentioned in the past, a number of chelating agents also have antiviral

activity.

For an example lets think about glutathione. I do know of children who

have recovered and excreted large amounts of metals using glutathione as

the major part of their treatment. This is wonderful. However, if these

children were autistic to begin with, then imbalances in their bodies

allowed the condition to occur in the first place. Underlying factors

such

as methylation cycle mutations, chronic viral and bacterial infection,

heavy metal exposure all led to creating a condition of autism. Once we

have used ie glutathione to get rid of metals (glutathione also has

antiviral activity) we have eliminated some of the risk factors. If we

do

not fix the underlying methylation cycle mutations, there is nothing to

prevent virus from accumulating in the body again. The mechanism for

viral

silencing is still broken. The mechanism for turning on and off DNA

expression called epigenetics is still broken (the BBC article that came

out yesterday about food and methionine relied on epigenetics to be

functioning properly to work). The ability to make some of the building

blocks for DNA and RNA that requires methylation is still broken. Just

to

name a few consequences of in adequate methylation. Basically, until the

methylation cycle is addressed it is like a time bomb waiting to go off.

This is why it is so important to look at this pathway and to bypass

mutations in this pathway.

I will make some slides for February that depict this so that you have a

visual image of DNA and RNA based viral integration. I strongly suggest

the RNA Educational Starter Kit that includes the book and several DVDs

for visual aids for more information on this topic.

Because valtrex is not the best in the world for the liver I would take

a

break on it until you get to metals 3 and 4. Although valtrex is

indicated

for DNA viruses, I just read some literature last night that indicated

that the enzymes involved in replicating rubella do have some similarity

to those for herpes. I need to look into this further and see how much

homology they have and in what way. So, to be extra conservative on this

one, if you want to use valtrex in conjunction with the metals we can

think about it for metals 3 as well as metals 4.

In answer to the question of where do we get the viruses from, they are

in

our environment. We are exposed all the time. Some viruses need to be

transmitted by direct saliva transmission from one person to another.

Some

are transmitted sexually, some by mosquitoes. Some viruses are

transmitted

in the air, by coughing and sneezing. There is no way around viral

exposure unless you become the boy in the bubble. This is why our

methylation pathways need to function properly. If there is no way

around

exposure, then we need to be functioning in a proper fashion so that we

can defend ourselves against the viruses.

T cells, the cellular arm of the immune system, are critical for viral

defense. When we are exposed to a new " threat " to our immune systems,

like

a virus, the T cell clones expand. This means that when the T cells see

a

threat they respond by multiplying. In order to multiply it takes new

DNA

synthesis. New DNA synthesis means we need the building blocks for DNA.

The methylation cycle helps to make the building blocks for DNA. One of

the four major building blocks, thymidine has a methyl group. The final

step in making thymidine requires that a methyl group be added. So, if

we

have methylation cycle issues, it is not just that we cannot silence the

virus by sticking a methyl group on the viral DNA to keep it quiet. We

also cannot expand our T cell clones to defend ourselves from the virus.

It is like letting the enemy multiply and add more troops on the one

hand

(no methyl group silencing) and only having the bare minimum response

from

our troops, and not letting any more of our good guys get into the field

to defend us from the invaders (no new DNA synthesis). To take it a step

further...if we have limited DNA synthesis we cannot make new cells. So

we

cannot repair the damage that the invaders have caused. So without

proper

methylation function we sit there, surrounded by invaders without any

support from our troops with burned out buildings all around us. Sounds

like something from one of those science fiction movies!

We are blessed however, in that we know what is going on. We can measure

where the mutations or road blocks occur. We can bypass these mutations

and we can restore function to the system. It may take a while to kick

out

the invaders and repair the damage. The longer the invaders have been

around, and the more time they have had to build up huge armies, the

longer it will take to get rid of them. But eventually we do, no matter

how many troops they have.

If the rest of the system is not in balance and the methylation cycle is

not supported to address mutations, I am not surprised that the valtrex

is

not having an effect.

> >

> > NOT a Yasko expert, but....

> > I happened to have been looking at " Methyl, Lipid and Sulfur donors "

> > post this a.m.

> > Here's the link.

> > http://www.autismanswer.com/forum/viewtopic.php?=2853

> >

>