Chlamydia pneumoniae infection: an additional factor for chronic allograft rejec

May 29, 2006

" CHR(+) patients showed significantly lower HDL levels (47 mg/dL vs 58

mg/dL) and higher triglyceride levels (193 mg/dL vs 148 mg/dL). "

1: Transplant Proc. 2006 Jan-Feb;38(1):108-11. Related Articles, Links

Chlamydia pneumoniae infection: an additional factor for chronic allograft

rejection.

Kwiatkowski A, Wszola M, Nosek R, Podsiadly E, Meszaros J, Ostrowski K,

Lisik W, Michalak G, Chmura A, Kosieradzki M, ewicz R, Fesolowicz S,

Kasprzyk T, Paczek L, Durlik M, Persson K, Tylewska-Wierzbanowska S,

Rowinski W.

Department of General and Transplantation Surgery, Warsaw Medical

University, ul. Nowogrodzka 59, 02-006 Warsaw, Poland.

INTRODUCTION: Chronic rejection (CHR) of organ allografts, one of the most

significant problems in modern transplantation, is not fully understood.

This study sought to evaluate the influence of selected parameters on late

kidney transplant function. PATIENTS AND METHOD: The studied group consisted

of eighty-six patients who received allogeneic transplants between 1988 and

1999 for leukocyte Chlamydia pneumoniae-DNA, immunoglobulin (Ig)A/IgG anti-C

pneumoniae, blood lipids, ischemic damage in the donor and during organ

preservation, HLA mismatch, and acute rejection episodes. RESULTS:

Eighty-six patients were segregated as 26 patients (30%) with histologically

proven chronic graft rejection (CHR[+]) and 59 patients (70%) without

(CHR[-]). The presence of C pneumoniae-DNA in peripheral blood leukocytes

was significantly more frequent in CHR(+) than CHR(-) group (46% vs 20%).

Patients with leukocytes positive for C pneumoniae-DNA more frequently (50%)

had CHR than patients negative for C pneumoniae-DNA (22%). CHR(+) patients

showed significantly lower HDL levels (47 mg/dL vs 58 mg/dL) and higher

triglyceride levels (193 mg/dL vs 148 mg/dL). To study the cumulative effect

of differences between the CHR(+) and CHR(-) groups, we applied a multiple

binary logistic regression analysis. An econometric model enabled us to

calculate the probability of CHR for a given patient taking into account

covariates chosen by means of stepwise selection: the presence of C

pneumoniae-DNA in blood leukocytes, the use of continuous pulsatile

perfusion in hypothermia, myocardial infarction occurrence, and triglyceride

concentrations. CONCLUSION: The presence of C pneumoniae-DNA in peripheral

blood leukocytes increased the risk of CHR, which may be predicted by a

multifactor analysis of chosen parameters.

PMID: 16504677 [PubMed - indexed for MEDLINE]

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