Re: Re: Potentially Life-Threatening Bloodstream Infection

[Guest guest]

Or is it that the low MSH will contribute to candida infection ? Healthy levels

of MSH are needed to keep Staph and Candida at bay (Pubmed).

Jay

erikmoldwarrior <erikmoldwarrior@...> wrote:

> Patients at high risk for candidemia and systemic candidiasis

(Candida infection that spreads throughout the body) include those

with compromised immune systems, stem-cell and organ-transplant

recipients, patients on chemotherapy, patients with catheters,

critically ill patients in intensive care units, surgical patients

> and patients on prolonged antibiotic therapy.

> This list should also probably include all of us who have been

exposed to toxic mold!!!!!!!

Considering that mycotoxins are antibiotics, toxic mold IS " prolonged

antibiotic chemotherapy " ! - including immunosuppressive cyclosporins

in addition to protein synthesis inhibitors and macrophage " burst

function " dysregulating agents.

I made an appointment with the NIH Candida adherence research project

in 2002 to attempt to discuss this with a qualified researcher, and

was amazed to find that this particular NIH Dr/Prof had personally

conducted Stachybotrys evacuations - and was quite aware of the

potential for mycotoxin induced disaster. However Dr/Prof L was not

interested in pursuing this subject and said he was not aware of any

researcher that he could refer me to, or who might be interested in

this topic.

Interesting that the NIH has an official stance that is at variance

with public policy and is at total odds with the way that certain

government buildings, such as the homes of Governers are treated.

Ever heard that Blues song: " Why don't my old dog bark, when YOU come

around? "

-

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[Guest guest]

Hi Barb,

During our recent appt , Dr.S did mention that pharmaceutical companies are

filing patents to use MSH for candida treatments. I don't know why he doesn't

test for candida though. It is easier to guess if one has candida than to guess

Staph.

Jay

barb1283 <barb1283@...> wrote:

If that's the case, I wonder why Dr Shoemaker doesn't check for

Candida infections. He didn't test me for anything but the staph

sinus infection. Perhaps he feels if he gets you over the

mycotoxosis, then your body's own immune system will kick 'butt'

again. I don't know. Any feedback on this?

>

> > Patients at high risk for candidemia and systemic candidiasis

> (Candida infection that spreads throughout the body) include

those

> with compromised immune systems, stem-cell and organ-transplant

> recipients, patients on chemotherapy, patients with catheters,

> critically ill patients in intensive care units, surgical

patients

> > and patients on prolonged antibiotic therapy.

>

> > This list should also probably include all of us who have been

> exposed to toxic mold!!!!!!!

>

>

> Considering that mycotoxins are antibiotics, toxic mold

IS " prolonged

> antibiotic chemotherapy " ! - including immunosuppressive

cyclosporins

> in addition to protein synthesis inhibitors and macrophage " burst

> function " dysregulating agents.

>

> I made an appointment with the NIH Candida adherence research

project

> in 2002 to attempt to discuss this with a qualified researcher,

and

> was amazed to find that this particular NIH Dr/Prof had personally

> conducted Stachybotrys evacuations - and was quite aware of the

> potential for mycotoxin induced disaster. However Dr/Prof L was

not

> interested in pursuing this subject and said he was not aware of

any

> researcher that he could refer me to, or who might be interested

in

> this topic.

> Interesting that the NIH has an official stance that is at

variance

> with public policy and is at total odds with the way that certain

> government buildings, such as the homes of Governers are treated.

>

> Ever heard that Blues song: " Why don't my old dog bark, when YOU

come

> around? "

> -

>

>

>

>

>

>

>

>

>

>

> FAIR USE NOTICE:

>

>

>

>

>

>

[Guest guest]

Alpha MSH is Alpha Melanocyte Stimulating Hormone.

I agree with what you say on systemic candida.

Jay

barb1283 <barb1283@...> wrote:

It's easier to guess if Candida is gut and mouth, etc. but systemic is

when it gets past the gut into organs and is not easy to guess about.

I'm a little confused though. How would doctors use MSH for candida

treatments? It's been awhile since I looked at my test results but

isn't MSH a test?

--- In , jay krishnaa <jkrishnaa@...>

wrote:

>

> Hi Barb,

>

> During our recent appt , Dr.S did mention that pharmaceutical

companies are filing patents to use MSH for candida treatments. I

don't know why he doesn't test for candida though. It is easier to

guess if one has candida than to guess Staph.

>

> Jay

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[Guest guest]

Hi Barb,

I am assuming they would use MSH analogues (synthetic Alpha MSH). Here's an

article from Pubmed.

J Med Chem. 2003 Feb 27;46(5):850-5. Related Articles,

Links

Novel alpha-melanocyte stimulating hormone peptide analogues with high

candidacidal activity.

Grieco P, Rossi C, Colombo G, Gatti S, Novellino E, Lipton JM, Catania A.

Department of Pharmaceutical Chemistry and Toxicology, University of Naples,

80131 Naples, Italy.

alpha-Melanocyte stimulating hormone (alpha-MSH) is an endogenous linear

tridecapeptide with potent antiinflammatory effects. We recently demonstrated

that alpha-MSH and its C-terminal sequence Lys-Pro-Val (alpha-MSH (11-13)) have

antimicrobial effects against two major and representative pathogens:

Staphylococcus aureus and Candida albicans. In an attempt to improve the

candidacidal activity of alpha-MSH and to better understand the peptide

structure-antifungal activity relations, we designed and synthesized novel

peptide analogues. Because previous data suggested that antimicrobial effects of

alpha-MSH were receptor-mediated, we chose to focus on the sequence alpha-MSH

(6-13), which contains the invariant core sequence His-Phe-Arg-Trp (6-9) that is

important for binding to the known melanocortin receptors and also contains the

sequence Lys-Pro-Val (11-13) that is known to be important for antimicrobial

activity. In this structure-activity study, we discovered several compounds that

have greater candidacidal activity than alpha-MSH. The peptide

[d-Nal-7,Phe-12]-alpha-MSH (6-13) was the most potent of the analogues tested.

The present results are very encouraging because they show the great potential

of these peptides as a truly novel class of candidacidal compounds.

barb1283 <barb1283@...> wrote: Hi Jay, I'm interested in your post but

how would a doctor use Alpha

Melanocyte Stimulating Hormone to treat Candida?? Perhaps you are

just reporting what was said and don't know how they would, just

asking just in case you do understand. barb

--- In , jay krishnaa <jkrishnaa@...>

wrote:

>

> Alpha MSH is Alpha Melanocyte Stimulating Hormone.

>

> I agree with what you say on systemic candida.

>

> Jay

>

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