Your Brain: Use it or Lose it

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Steer Clear of Alzheimer's--Stay Active

By Merritt McKinney

NEW YORK (Reuters Health) - Staying active, both mentally and physically,

may reduce the risk of Alzheimer's disease (news - web sites), researchers

report.

In a new study, the odds of developing Alzheimer's were nearly quadrupled

in people who were less active during their leisure time between the ages

of 20 and 60 compared with their peers. This seemed to be true regardless

of the type of activity, although spending time in intellectual pursuits

appeared to be the most beneficial.

It is still uncertain whether an inactive lifestyle itself increases the

risk of Alzheimer's disease or simply reflects the earliest stages of the

disease, but according to the study's lead author, it is a good idea to

keep the brain in shape throughout life.

``A passive life is not best for the brain,'' said Dr. P. Friedland,

of Case Western Reserve University School of Medicine and University

Hospitals of Cleveland in Ohio.

``The brain is an organ just like every other organ in the body,'' he told

Reuters Health. Just as physical activity is good for the heart, muscles

and lungs, learning is important for keeping the brain healthy, he noted.

People often compare the brain to a computer, but there is an important

difference, according to Friedland. While a computer's hardware does not

change, the size and structure of neurons and the connections between them

actually change as a person learns, he explained.

But exercising the brain means more than hitting the books. Traveling,

learning a musical instrument or foreign language, and participating in

social and community activities can all help keep the brain active, he said.

Several studies have investigated the connection between work, education

and the risk of Alzheimer's disease, and it appears that people who are

better educated and more accomplished on the job are less likely to develop

the disease. But there has been little research into the effect of leisure

activities on the risk of Alzheimer's disease.

In the current study, Friedland and his colleagues compared the leisure

activities of 193 people believed to have Alzheimer's disease and a

``control'' group of 358 healthy people the same age. The researchers asked

the participants (or family members, friends and acquaintances in the case

of people with Alzheimer's) how often they participated in more than two

dozen activities when they were between the ages of 20 and 60.

The researchers asked about three different types of leisure activities.

Physical activities included sports, working out in a gym, biking,

gardening, ice skating, walking and jogging. Examples of intellectual

activities included reading, doing puzzles, playing a musical instrument,

painting, woodworking, playing cards or board games, and performing home

repairs. Some of the passive activities included watching television,

listening to music, attending social clubs, talking on the phone, visiting

with friends and attending religious services.

People with Alzheimer's disease were less likely to participate in passive,

intellectual and physical activities between the ages of 20 and 60,

Friedland and his colleagues report in the March 13th issue of the journal

Proceedings of the National Academy of Sciences (news - web sites). Even

after the investigators took into account factors that could have

influenced the risk of Alzheimer's, including age, sex, education and

socioeconomic status, people who participated in fewer activities than the

average were 3.85 times more likely to develop the memory-robbing illness.

The differences between healthy participants and those with Alzheimer's

disease were greatest in terms of intellectual activities.

``People with Alzheimer's disease were less active in passive, physical and

intellectual activities,'' Friedland said. Since intellectual activities

appear to keep the brain healthy, adults should have more opportunities to

participate in learning activities, he said. This is especially true for

older people, who often are limited in what sort of activities they can

participate in.

Unfortunately, many elderly--and younger people as well--spend much of

their leisure time watching television, Friedland said. He noted that the

only activity that Alzheimer's patients performed more frequently than the

healthy controls was watching television.

SOURCE: Proceedings of the National Academy of Sciences 2001;98:3440-

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