Guest guest Posted March 9, 2008 Report Posted March 9, 2008 BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors http://tinyurl.com/2fpoba For those of you contemplating Tasigna, there is a very interesting article in the Winter 2007 edition of Cure magazine. In phase II studies, Tasigna decreassed white blood cell counts in 137 (74%) of 185 patients. It eliminated the number of cells carrying the abnormal Ph+ in 145 of 279 patients or 52%. Those in acelerated phase showed a 59% decrease in WBC. 23patients saw a reduction or elimination of the PH+ containing cells, or about 36%. Side effects of Tasigna can be rash, headache and low blood counts. For more information, go to http://www.tasigna.com/index.jsp I wish the buck stopped here, I could use a few, Lottie Quote
Guest guest Posted March 9, 2008 Report Posted March 9, 2008 On Tasigna (Nilotinib) from Blood Feb. 2008 : Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is active in patients with imatinib-resistant or -intolerant accelerated-phase chronic myelogenous leukemia http://tinyurl.com/2nbruq Also in 2008 several articles on new and/or in trials molecules (BMS-214662 , PHA-739358, BAG956, Ki11502, SKI-606). Marcos. On Sat, Mar 8, 2008 at 11:39 PM, Lottie Duthu <lotajam@...> wrote: > > > > > BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and > progenitor cells and synergizes with tyrosine kinase inhibitors > http://tinyurl.com/2fpoba > > For those of you contemplating Tasigna, there is a very interesting article > in the Winter 2007 edition of Cure magazine. In phase II studies, Tasigna > decreassed white blood cell counts in 137 (74%) of 185 patients. It > eliminated the number of cells carrying the abnormal Ph+ in 145 of 279 > patients or 52%. Those in acelerated phase showed a 59% decrease in WBC. > 23patients saw a reduction or elimination of the PH+ containing cells, or > about 36%. Side effects of Tasigna can be rash, headache and low blood > counts. For more information, go to http://www.tasigna.com/index.jsp > > I wish the buck stopped here, I could use a few, > Lottie > > Quote
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