Re: Researchers Seek Key to Antiaging In Calorie Cutback

[Guest guest]

Arturo: thanks for this interesting article (which is only partly reproduced below). This seems to fly in the face of the study posted here, and recently re-discussed, which concludes that 3-5 glasses of wine a day does extend life. Or am I missing something?

on 10/31/2006 6:28 AM, Arturo Veve at volae@... wrote:

The resveratrol doses used in the life-span-extension studies in animals were far higher than the amount people can get by drinking wine -- they were roughly equivalent to hundreds of glasses a day. Resveratrol is available as a dietary supplement, but to replicate the doses used in the studies, a person would need to take scores of pills a day. (Sirtris says it is developing prescription drugs that work like resveratrol but are hundreds of times more potent.) The dietary supplements haven't been tested in clinical trials, so their efficacy isn't proven, nor is it clear what dose might make people live healthier or longer. And although they seem safe at modest doses, megadoses may not be.

[Guest guest]

Perhaps the problem lies in the fact that " wine " is not being well-

defined. The amount of resveratrol in red wine can vary by a factor

of 40! Pinot Noir has the highest levels.

>

> The resveratrol doses used in the life-span-extension studies in

animals

> were far higher than the amount people can get by drinking wine --

they were

> roughly equivalent to hundreds of glasses a day. Resveratrol is

available as

> a dietary supplement, but to replicate the doses used in the

studies, a

> person would need to take scores of pills a day. (Sirtris says it

is

> developing prescription drugs that work like resveratrol but are

hundreds of

> times more potent.) The dietary supplements haven't been tested in

clinical

> trials, so their efficacy isn't proven, nor is it clear what dose

might make

> people live healthier or longer. And although they seem safe at

modest

> doses, megadoses may not be.

>