The Immediate Negative Effects Of One High Saturated Fat Meal

[Guest guest]

Most interesting, is the saturated fat they used in

this study, was coconut oil, the one being touted as a

" miracle " food these days...

And, these effects do not show up in fasting lipid

profiles..

Regards

Jeff

Consumption of Saturated Fat Impairs the

Anti-Inflammatory Properties of High-Density

Lipoproteins and Endothelial Function

J Am Coll Cardiol, 2006; 48:715-720, © 2006 by the

OBJECTIVES: The purpose of this study was to

investigate the influence of dietary fatty acids on

the anti-inflammatory properties of high-density

lipoproteins (HDL) and vascular function.

BACKGROUND: The effect of dietary fatty acids on

atherogenesis remains uncertain.

METHODS: Fourteen adults consumed an isocaloric meal

containing either a polyunsaturated or a saturated fat

on 2 occasions. The effects of post-prandial HDL on

endothelial cell expression of intercellular adhesion

molecule-1 (ICAM-1) and vascular cell adhesion

molecule-1 (VCAM-1) were determined. Flow-mediated

dilation (FMD) and microvascular reactivity were

assessed before and 3 and 6 h after the meal.

RESULTS: Plasma triglycerides, insulin, and

nonesterified fatty acids rose after the meals. The

HDL collected 6 h after the saturated meal were less

effective than HDL isolated from fasting plasma in

terms of their ability to inhibit expression of ICAM-1

and VCAM-1, whereas HDL collected 6 h after the

polyunsaturated meal had an inhibitory activity that

was greater than that of HDL collected from fasting

plasma (p < 0.004 and p = 0.01 for comparison of

effect of meals on ICAM-1 and VCAM-1, respectively).

Post-hyperemic microvascular flow significantly

increased at 3 h after the polyunsaturated meal by 45

± 14% and by 21 ± 11% after the saturated meal. The

FMD decreased 3 h after the saturated meal by 2.2 ±

0.9% (p < 0.05 compared with baseline) and by 0.9 ± 1%

after the polyunsaturated meal.

CONCLUSIONS: Consumption of a saturated fat reduces

the anti-inflammatory potential of HDL and impairs

arterial endothelial function. In contrast, the

anti-inflammatory activity of HDL improves after

consumption of polyunsaturated fat. These findings

highlight novel mechanisms by which different dietary

fatty acids may influence key atherogenic processes.