Re: The Immediate Negative Effects Of One High Saturated Fat Meal

[Guest guest]

I've been looking for something that specifically debunks the consumption of coconut oil (as if it was somehow better than other sat fats)..thank you for posting this...On 9/1/06, Jeff Novick <chefjeff40@...> wrote:

Most interesting, is the saturated fat they used in

this study, was coconut oil, the one being touted as a

" miracle " food these days...

And, these effects do not show up in fasting lipid

profiles..

Regards

Jeff

Consumption of Saturated Fat Impairs the

Anti-Inflammatory Properties of High-Density

Lipoproteins and Endothelial Function

J Am Coll Cardiol, 2006; 48:715-720, © 2006 by the

OBJECTIVES: The purpose of this study was to

investigate the influence of dietary fatty acids on

the anti-inflammatory properties of high-density

lipoproteins (HDL) and vascular function.

BACKGROUND: The effect of dietary fatty acids on

atherogenesis remains uncertain.

METHODS: Fourteen adults consumed an isocaloric meal

containing either a polyunsaturated or a saturated fat

on 2 occasions. The effects of post-prandial HDL on

endothelial cell expression of intercellular adhesion

molecule-1 (ICAM-1) and vascular cell adhesion

molecule-1 (VCAM-1) were determined. Flow-mediated

dilation (FMD) and microvascular reactivity were

assessed before and 3 and 6 h after the meal.

RESULTS: Plasma triglycerides, insulin, and

nonesterified fatty acids rose after the meals. The

HDL collected 6 h after the saturated meal were less

effective than HDL isolated from fasting plasma in

terms of their ability to inhibit expression of ICAM-1

and VCAM-1, whereas HDL collected 6 h after the

polyunsaturated meal had an inhibitory activity that

was greater than that of HDL collected from fasting

plasma (p < 0.004 and p = 0.01 for comparison of

effect of meals on ICAM-1 and VCAM-1, respectively).

Post-hyperemic microvascular flow significantly

increased at 3 h after the polyunsaturated meal by 45

± 14% and by 21 ± 11% after the saturated meal. The

FMD decreased 3 h after the saturated meal by 2.2 ±

0.9% (p < 0.05 compared with baseline) and by 0.9 ± 1%

after the polyunsaturated meal.

CONCLUSIONS: Consumption of a saturated fat reduces

the anti-inflammatory potential of HDL and impairs

arterial endothelial function. In contrast, the

anti-inflammatory activity of HDL improves after

consumption of polyunsaturated fat. These findings

highlight novel mechanisms by which different dietary

fatty acids may influence key atherogenic processes.

[Guest guest]

Hi folks:

I hadn't realized until I looked at some receipes recently that most

Thai dishes contain either coconut oil, coconut milk, ground coconut

or contain stuff that is deep fried. They may APPEAR on casual

inspection as if they might be healthy. But closer inspection often

reveals a different conclusion.

Rodney.

> >

> > Most interesting, is the saturated fat they used in

> > this study, was coconut oil, the one being touted as a

> > " miracle " food these days...

> >

> > And, these effects do not show up in fasting lipid

> > profiles..

> >

> > Regards

> > Jeff

> >

> > Consumption of Saturated Fat Impairs the

> > Anti-Inflammatory Properties of High-Density

> > Lipoproteins and Endothelial Function

> > J Am Coll Cardiol, 2006; 48:715-720, © 2006 by the

> >

> > OBJECTIVES: The purpose of this study was to

> > investigate the influence of dietary fatty acids on

> > the anti-inflammatory properties of high-density

> > lipoproteins (HDL) and vascular function.

> >

> > BACKGROUND: The effect of dietary fatty acids on

> > atherogenesis remains uncertain.

> >

> > METHODS: Fourteen adults consumed an isocaloric meal

> > containing either a polyunsaturated or a saturated fat

> > on 2 occasions. The effects of post-prandial HDL on

> > endothelial cell expression of intercellular adhesion

> > molecule-1 (ICAM-1) and vascular cell adhesion

> > molecule-1 (VCAM-1) were determined. Flow-mediated

> > dilation (FMD) and microvascular reactivity were

> > assessed before and 3 and 6 h after the meal.

> >

> > RESULTS: Plasma triglycerides, insulin, and

> > nonesterified fatty acids rose after the meals. The

> > HDL collected 6 h after the saturated meal were less

> > effective than HDL isolated from fasting plasma in

> > terms of their ability to inhibit expression of ICAM-1

> > and VCAM-1, whereas HDL collected 6 h after the

> > polyunsaturated meal had an inhibitory activity that

> > was greater than that of HDL collected from fasting

> > plasma (p < 0.004 and p = 0.01 for comparison of

> > effect of meals on ICAM-1 and VCAM-1, respectively).

> > Post-hyperemic microvascular flow significantly

> > increased at 3 h after the polyunsaturated meal by 45

> > ± 14% and by 21 ± 11% after the saturated meal. The

> > FMD decreased 3 h after the saturated meal by 2.2 ±

> > 0.9% (p < 0.05 compared with baseline) and by 0.9 ± 1%

> > after the polyunsaturated meal.

> >

> > CONCLUSIONS: Consumption of a saturated fat reduces

> > the anti-inflammatory potential of HDL and impairs

> > arterial endothelial function. In contrast, the

> > anti-inflammatory activity of HDL improves after

> > consumption of polyunsaturated fat. These findings

> > highlight novel mechanisms by which different dietary

> > fatty acids may influence key atherogenic processes.

> >

> >

> >

>

[Guest guest]

Coconut oil has 18% myristic acid, which is the saturated fatty acid

that increases cholesterol levels the most, according to the Hegsted

equation. Palm kernel oil has 16% myristic acid, and butter has 11%

myristic acid.

Coconut oil, also called copra oil, has been replacing hydrogenated

fats because manufacturers are trying to produce foods that don't turn

rancid on the shelves while avoiding " trans " fats.

Many Thai and Indonesian dishes use coconut milk copiously.

Fortunately, coconut milk is not all fat.

One good use of coconut oil is as a skin lotion.

Tony

> > >

> > > Most interesting, is the saturated fat they used in

> > > this study, was coconut oil, the one being touted as a

> > > " miracle " food these days...

> > >

> > > And, these effects do not show up in fasting lipid

> > > profiles..

> > >

> > > Regards

> > > Jeff

> > >

> > > Consumption of Saturated Fat Impairs the

> > > Anti-Inflammatory Properties of High-Density

> > > Lipoproteins and Endothelial Function

> > > J Am Coll Cardiol, 2006; 48:715-720, © 2006 by the

> > >

> > > OBJECTIVES: The purpose of this study was to

> > > investigate the influence of dietary fatty acids on

> > > the anti-inflammatory properties of high-density

> > > lipoproteins (HDL) and vascular function.

> > >

> > > BACKGROUND: The effect of dietary fatty acids on

> > > atherogenesis remains uncertain.

> > >

> > > METHODS: Fourteen adults consumed an isocaloric meal

> > > containing either a polyunsaturated or a saturated fat

> > > on 2 occasions. The effects of post-prandial HDL on

> > > endothelial cell expression of intercellular adhesion

> > > molecule-1 (ICAM-1) and vascular cell adhesion

> > > molecule-1 (VCAM-1) were determined. Flow-mediated

> > > dilation (FMD) and microvascular reactivity were

> > > assessed before and 3 and 6 h after the meal.

> > >

> > > RESULTS: Plasma triglycerides, insulin, and

> > > nonesterified fatty acids rose after the meals. The

> > > HDL collected 6 h after the saturated meal were less

> > > effective than HDL isolated from fasting plasma in

> > > terms of their ability to inhibit expression of ICAM-1

> > > and VCAM-1, whereas HDL collected 6 h after the

> > > polyunsaturated meal had an inhibitory activity that

> > > was greater than that of HDL collected from fasting

> > > plasma (p < 0.004 and p = 0.01 for comparison of

> > > effect of meals on ICAM-1 and VCAM-1, respectively).

> > > Post-hyperemic microvascular flow significantly

> > > increased at 3 h after the polyunsaturated meal by 45

> > > ± 14% and by 21 ± 11% after the saturated meal. The

> > > FMD decreased 3 h after the saturated meal by 2.2 ±

> > > 0.9% (p < 0.05 compared with baseline) and by 0.9 ± 1%

> > > after the polyunsaturated meal.

> > >

> > > CONCLUSIONS: Consumption of a saturated fat reduces

> > > the anti-inflammatory potential of HDL and impairs

> > > arterial endothelial function. In contrast, the

> > > anti-inflammatory activity of HDL improves after

> > > consumption of polyunsaturated fat. These findings

> > > highlight novel mechanisms by which different dietary

> > > fatty acids may influence key atherogenic processes.

> > >

> > >

> > >

> >

>