CR works in humans

[Guest guest]

Hi ALl,

The other shoe has dropped it appears, in the pdf-available below paper. There

is a

response to human CR naysayers.

Yu BP.

Why calorie restriction would work for human longevity.

Biogerontology. 2006 May 5; [Epub ahead of print]

PMID: 16676136 http://tinyurl.com/qfrt9

Experimentally imposed calorie restriction (CR) is shown to result in the

most

reprExperimentally imposed calorie restriction (CR) is shown to result in the

most

reproducible endpoint of lifespan extension in all animals models tested. In

this

presentation, the question of CR's effect on human longevity is reviewed by

discussing data pertinent to the putative efficacy of CR on humans. Arguments

are

presented in support of this possibility based on CR's unique abilities to

retard

biological functional declines and to deter pathological processes, both of

which

are major targets of deleterious oxidative stress. To delineate the cellular and

molecular mechanisms of CR's efficacy on human longevity, this review elaborates

on

the modulation of CR on the inflammatory process, a common risk factor for many

chronic diseases. Discussions also include evidence from human data on the

effect of

CR in the loss of body weight, known to suppress inflammatory cytokines,

subsequently leading to the reduction of chronic diseases known to compromise

the

functional longevity of humans.

Conclusion ... This presentation discusses evidence supporting the efficacy

of

CR on the human longevity. This evidence is based on CR’s ability to suppress

the

oxidative stress-induced, molecular inflammatory processes that underlie many of

the

life-shortening diseases. At present, oxidative stress is viewed as the likely

prime

cause of the aging process, as accumulated evidenceoverwhelmingly links

increased

oxidative damage with altered cellular redox balance and functions. From an

evolutionary perspective, the utilization of oxygen as a life-supporting means

makes

oxidative stress an inescapable part of an organism’s biological functions,

including inflammatory responses for its overall survival strategy. The ability

of

CR to modulate innate oxidative stress and the inflammatory process of

biological

systems is effective. Thus, the outcomes from CR can be considered as

evolutionarily, adaptive defense responses under oxidative environments, living

conditions from which humans cannot be excluded. It is difficult to see why

these

defense mechanisms that protect against deleterious biological processes and

debilitating diseases would work only lower animals, and not for humans.

-- Al Pater, PhD; email: old542000@...

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