Okinawan centenarian advantage

[Guest guest]

It appears that the longest-lived of the long-lived Okinawans have genetic

features

that allow them to greatly exceed the longevity of the general Okinawan

population.

The difference between the longest-lived Okinawans men and women was not as

great as

the difference in the general Okinawan men and women. " Table 2 ... does not

mean

that the mortality advantage seen in centenarian siblings is increasing at older

ages. ... cumulative survival probability increases rapidly in centenarian

siblings

as they age because the cumulative mortality advantage of the centenarian

siblings

grows over the course of their lives. ... "

Since CR should similarly, or maybe even more effectively than for the Okinawan

longest lived families, extend our lives, would this possibly indicate that CRed

men

and women would fare relatively more comparably with respect to how long we

live?

Willcox BJ, Willcox DC, He Q, Curb JD, Suzuki M.

Siblings of okinawan centenarians share lifelong mortality advantages.

J Gerontol A Biol Sci Med Sci. 2006 Apr;61(4):345-54.

PMID: 16611700 http://tinyurl.com/luha4

.... We analyzed the pedigrees of 348 centenarian families with 1142 siblings and

compared sibling survival with that of the 1890 Okinawan general population

cohort.

Both male and female centenarian siblings experienced approximately half the

mortality of their birth cohort-matched counterparts. This mortality advantage

was

sustained and did not diminish with age in contrast to many environmentally

based

mortality gradients, such as education and income. Cumulative survival

advantages

for this centenarian sibling cohort increased over the life span such that

female

centenarian siblings had a 2.58-fold likelihood, and male siblings a 5.43-fold

likelihood, versus their birth cohorts, of reaching the age of 90 years. These

data

support a significant familial component to exceptional human longevity.

Table 1. Relative Mortality Rate (MR) With 95% Confidence Intervals (CI) of

Centenarian Siblings Versus Okinawa 1890 Birth Cohort.

---Women---Men

====================================

Age Group, y---Relative MR 95% CI---Relative MR 95% CI

====================================

0 0.18 0.00–0.42 0.07 0.00–0.22

1–4 0.12 0.02–0.22 0.07 0.00–0.17

5–9 0.07 0.00–0.16 0.08 0.00–0.20

10–14 0.43 0.05–0.81 0.32 0.01–0.63

15–19 0.08 0.00–0.23 0.71 0.22–1.20

20–24 0.45 0.21–0.70 0.74 0.38–1.11

25–29 0.31 0.13–0.48 0.39 0.16–0.62

30–34 0.35 0.20–0.51 0.42 0.24–0.59

35–39 0.43 0.18–0.69 0.39 0.13–0.64

40–44 0.79 0.42–1.15 0.87 0.52–1.23

45–49 0.48 0.20–0.77 0.28 0.11–0.46

50–54* 0.83 0.52–1.15 0.55 0.31–0.79

55–59 0.51 0.28–0.74 0.34 0.18–0.50

60–64* 1.25 0.76–1.74 0.99 0.66–1.32

65–69* 0.49 0.24–0.74 0.51 0.31–0.71

70–74* 0.96 0.70–1.23 1.00 0.75–1.24

75–79 0.39 0.25–0.54 0.35 0.22–0.48

80–84 0.54 0.39–0.68 0.69 0.52–0.86

85–89 0.76 0.60–0.93 0.57 0.40–0.74

====================================

*These age groups did not have the corresponding data for Okinawa general

population. The data from nearest time were used in the analysis.

Table 2. Cumulative Survival Ratios (CSRs) with 95% Confidence Intervals (CI)

for

Siblings of Centenarians Versus Okinawan 1890 Birth Cohort.

====================================

---Women---Men

Age, y---CSR 95% CI---CSR 95% CI

====================================

20 1.00 1.00–1.00 1.00 1.00–1.00

25 1.03 1.01–1.04 1.01 1.00–1.03

30 1.08 1.06–1.10 1.05 1.03–1.07

35 1.15 1.13–1.18 1.13 1.09–1.16

40 1.19 1.16–1.22 1.16 1.13–1.20

45 1.20 1.16–1.23 1.17 1.13–1.21

50 1.23 1.19–1.27 1.25 1.20–1.30

55 1.24 1.19–1.29 1.30 1.25–1.37

60 1.29 1.24–1.35 1.44 1.37–1.51

65 1.28 1.22–1.34 1.45 1.36–1.53

70 1.33 1.26–1.40 1.57 1.47–1.68

75 1.35 1.27–1.43 1.62 1.48–1.76

80 1.56 1.45–1.67 2.17 1.96–2.38

85 1.94 1.78–2.10 2.97 2.59–3.35

90 2.58 2.28–2.87 5.43 4.52–6.32

-- Al Pater, alpater@...

__________________________________________________