to Rodney re obesity

[Guest guest]

Hi Rodney,

So, I guess you suspect the mice of sneaking into the refrigerator at night?

A calorie is determined by a single way of oxidizing a fuel source. There

is more than one way to metabolize fuel. A pile of food burned in a black

box may not tell us how a body oxidizes that same fuel. It is just an

imperfect way of standardizing an aspect of food value.

Bela Szepesi, USDA, is a carbohydrate metobolics researcher who was my

biochem prof. A citation/abstract follows, of one verified point of

diversity. He explained the difference in the way high fructose corn syrup

is metabolized and stored in the body contrasted to regular sugar. He told

his class in 1990 that it was expected that the diseases of the coming

generation would be obesity, fatty liver and diabetes - just from the

prevalence of high fructose corn syrup on American foods (not from an

increase of calories). It appears he was correct. Both high fructose corn

syrup and alcohol are metabolised in the liver and deposit fat directly into

the liver, which is different than sugar. All calories are not equal.

And even if they were, they are not handled equally by all bodies. You can

feed a bull dog and a grey hound exactly the same way, and you still get a

bull dog and a grey hound. People who work out on weights don't get the

same results. People who go to the same schools don't get the same results.

We are a myriad of variations on a theme.

If we both start out with a cup of water,and neithers spills nor drinks

their water, and you walk around with your cup open, and I put a lid on

mine, at the end of the day, I will probably have more water than you do.

It has nothing to do with the water. It has all to do with how we handled

the water.

These studies are ellucidating some of the variables which are making sense

out of a situation not satisfactorily explained by the 'facts', as is noted

in the studies. You may doubt their validity, but I have been responsible

for managing the weights of lots of animals, and I have been wondering when

science would catch up to reality on this issue. Finally they are.

PNAS | November 1, 1988 | vol. 85 | no. 21 | 7840-7843

Copyright © 1988 by the National Academy of Sciences

Molecular Diversity of Glucose-6-phosphate Dehydrogenase: Rat Enzyme

Structure Identifies NH2-terminal Segment, Shows Initiation from Sites

Nonequivalent in Different Organisms, and Establishes Otherwise Extensive

Sequence Conservation

Jeffery, Jane Soderling-Barros, Lynda A. Murray, J. Hansen,

Bela Szepesi, and Hans Jornvall

The NH2-terminal region of rat liver glucose-6-phosphate dehydrogenase (EC

1.1.1.49) is shown to differ radically from a reported amino acid sequence

for the fruit fly enzyme and from one for the human enzyme. The results

indicate considerable differences in the translational start point. However,

a close relationship with another reported sequence for the human enzyme is

established, now showing agreement between an indirectly deduced and a

directly analyzed NH2-terminal structure of this enzyme type. The results

provide evidence of one structural motif common to mammalian species but

also suggest that genetic inconstancy 5' to, or at the start of, the region

coding for the enzyme protein could be a source of intra- and interspecies

diversity. This is of interest in relation to the large number of genetic

variants of human glucose-6-phosphate dehydrogenase.

Best,

Kayce

From: " Rodney " <perspect1111@...>

Hi folks:

Well count me skeptical on this for now.

Are we logically to conclude from this that those who are able to

restrain their food intake and maintain a very healthy weight are by

definition sick because the only way anyone should be expected to be

able to control how much they eat is if they do not have the right

flora in their intestines to cause the absorption of all the nutients?

And is it only the obese people who are well, because their

intestines are so much more efficient?

Or are their body temperatures much lower than those of the very

healthy weight people? I think the opposite is true. Most people on

CR have lower body temperatures, not higher temperatures.

Has it been shown that the feces of very-healthy-weight people are

loaded with unabsorbed calories? Has it been shown they have lower

body temperatures? I think these things need to be demonstrated

before I will be able to take this seriously.

------

And as for the claimed increase in adipose, has it been demonstrated

that in these people who add a lot of adipose everything

else ........... bone, organs, brain etc. are reduced in size

when these people are on iso-caloric diets and compared with people

who do not have the adenovirus?

Calories do not just appear out of, or disappear into, the air. If

they are eating the same amount and they have added a lot more fat

then where did they get the calories from to do that?

------

Or is the argument that these adenoviruses make people uncontrollably

and irresistably hungry? So that it is not their fault they eat

more? Or is the excuse that the virus destroys a person's ability to

discipline the amount they eat?

Or are these people simply no different from the healthy weight

people, except that they voluntarily choose to eat more?

------

It seems to me that none of these studies so far go anywhere remotely

close to providing rational, and credible, answers to the above

questions.

Rodney.