Vitamin D - CHRISTOPHER Where are You? (!)

[Guest guest]

Hey :

IIRC you are taking very substantial vitamin D supplements. Are you

still? I am sure you have checked your BP. Is it OK?

Have you had other tests done that might be relevant to vitamin D?

Such as serum Ca, or serum vitamin D?

What do you think? We need your help here, imo.

Thank you.

Rodney.

--- In , " jwwright " <jwwright@e...>

wrote:

>

> I suggest those concerned with vit D read:

> http://www.ajcn.org/cgi/content/full/69/5/842#R16

> the refs ate the end of doc contain a lot of useful info.

> And the 53 articles cited by this article at the very end present

the state of knowledge (or lack of) and

> http://darwin.nap.edu/books/0309085373/html/1320.html

> shows the RDA at 9 yrs past the first article.

>

> Many of these are full text, and by the time I read all these, two

things I THINK :

> " The evidence suggests that efforts to improve vitamin D status,

for example by vitamin D supplementation, could reduce cancer

incidence and mortality at low cost, with few or no adverse effects. "

>

> " Vitamin D status differs by latitude and race, with residents of

the northeastern United States and individuals with more skin

pigmentation being at increased risk of deficiency. "

>

> The first I don't have full text, but perhaps this one sums up the

cancer story:

> Journal of the National Cancer Institute

> Volume 96(10), 19 May 2004, pp 735-736

>

> " " There's more to this vitamin D story, " said Lieberman,

M.D., program director of the Prostate and Urologic Cancer Research

Group in the National Cancer Institute's Division of Cancer

Prevention. " It is fascinating as a molecule. It's been shown to be

antiproliferative, proapoptotic, antiangiogenic. In prostate cancer,

its effects appear to be on the cell cycle, stopping growth by

upregulating [the tumor suppressor] p21. "

> He is quick to add, " Yet we don't have a bit of data that I could

show you to say it will work as a preventative. " Most of the evidence

is from ecologic, epidemiologic, and laboratory studies of cancers of

the prostate, breast, colon, and pancreas. For now, the available

studies in patients are treatment trials suggesting that vitamin D

may heighten the effects of chemotherapy or radiation. There have

been few studies of vitamin D as a cancer chemopreventive.

>

> " The American Academy of Dermatology is not moved. A July 2003

press release stated, " It is dangerous to mislead the public into

thinking that sunlight is a safe and effective 'cure' for other

health conditions. " AAD president L. Cornelison Jr., M.D.,

suggested that people take a multivitamin or drink a few glasses of

vitamin D-fortified milk every day, adding, " the dangers of exposing

oneself to carcinogenic UV light from the sun, even for a few

minutes, are firmly established. "

> " Is vitamin D insufficiency common? Yes. Is it likely a

contributing factor to prostate, breast, colon, and maybe some other

cancers? Yes, " said Schwartz. " Am I saying 'get thee to a skin

tannery'? No. "

>

> " I'm not sure how the sun-versus-supplement issue will play out, "

said Baron, whose study will include a questionnaire on sun exposure.

Welsh added, " It's still too early to know the right thing to do. "

>

> AND:

> " Abstract

> Vitamin D deficiency is more common than realized. It is making a

resurgence in neonates and is common in black patients and older

adults. Vitamin D deficiency not only causes generalized muscle

weakness, muscle aches, and bone aches and pains but also can

precipitate and exacerbate osteoporosis and cause osteomalacia.

Although the kidney plays a critical role in producing 1,25-

dihydroxyvitamin D, which is important for regulating calcium,

phosphorus, and bone metabolism, it is now recognized that a wide

variety of other tissues have the enzymatic machinery to produce 1,25-

dihydroxyvitamin D. Vitamin D receptors are common in most tissues in

the body, and the new revelation that many tissues produce 1,25-

dihydroxyvitamin D suggests a new important role for this hormone in

helping to maintain good health throughout life.

>

> Probably the best description of vit D pathways is in:

> Holick, F. PhD, MD Vitamin D: the underappreciated D-

lightful hormone that is important for skeletal and cellular health.

Current Opinion in Endocrinology & Diabetes. 9(1):87-98, February

2002.

> " Thus, in the absence of sufficient exposure to sunlight at least

1000 IU of vitamin D/d is probably required to maintain a healthy

level of 25 (OH)D "

>

> This article suggests to me if I was concerned about D status, I

would get a blood test:

>

> Holick, F. MD, PHD Vitamin D: Important for Prevention of

Osteoporosis, Cardiovascular Heart Disease, Type 1 Diabetes,

Autoimmune Diseases, and Some Cancers. Southern Medical Journal. 98

(10):1024-1026, October 2005.

> "

> Abstract:

> Vitamin D is very important for overall health and well-being. A

major source of vitamin D comes from exposure to sunlight.

Measurement of 25-hydroxyvitamin D in the blood and not 1,25-

dihydroxyvitamin D is used to determine vitamin D status. A blood

level of 25-hydroxyvitamin D of at least 20 ng/mL is considered to be

vitamin D sufficient. Vitamin D deficiency increases the risk of many

common cancers, multiple sclerosis, rheumatoid arthritis,

hypertension, cardiovascular heart disease, and type I diabetes. "

>

> Key Points

> * Ninety percent or more of our vitamin D requirement comes from

exposure to sunlight. Without sun exposure, 1,000 IU of vitamin D per

day is required. "

>

> I went thru this a cupla months ago and satisfied myself I had no

worry, but I added 800 IU to try it. The result was I think there may

be a selection problem in which pill to take. I notice they are

adding D3 to the orange juice calling it 25% of RDA.

>

> I must stick with the RDA until the powers sort it out.

>

> Regards.

>

[Guest guest]

Hi Rodney-

As of today, still on 1-3K units D3/day. Blood pressue has been OK (106/76), but I'm considering dropping most all supplements, at least for a while, just 'cause.

I'll continue to monitor.

Thanks!

On 1/30/06, Rodney <perspect1111@...> wrote:

Hey :IIRC you are taking very substantial vitamin D supplements. Are youstill? I am sure you have checked your BP. Is it OK?

Have you had other tests done that might be relevant to vitamin D?Such as serum Ca, or serum vitamin D?What do you think? We need your help here, imo.Thank you.Rodney.--- In , " jwwright " <jwwright@e...>wrote:>> I suggest those concerned with vit D read:>

http://www.ajcn.org/cgi/content/full/69/5/842#R16> the refs ate the end of doc contain a lot of useful info.> And the 53 articles cited by this article at the very end presentthe state of knowledge (or lack of) and

> http://darwin.nap.edu/books/0309085373/html/1320.html> shows the RDA at 9 yrs past the first article.>> Many of these are full text, and by the time I read all these, two

things I THINK :> " The evidence suggests that efforts to improve vitamin D status,for example by vitamin D supplementation, could reduce cancerincidence and mortality at low cost, with few or no adverse effects. "

>> " Vitamin D status differs by latitude and race, with residents ofthe northeastern United States and individuals with more skinpigmentation being at increased risk of deficiency. " >

> The first I don't have full text, but perhaps this one sums up thecancer story:> Journal of the National Cancer Institute> Volume 96(10), 19 May 2004, pp 735-736>> " " There's more to this vitamin D story, " said Lieberman,

M.D., program director of the Prostate and Urologic Cancer ResearchGroup in the National Cancer Institute's Division of CancerPrevention. " It is fascinating as a molecule. It's been shown to beantiproliferative, proapoptotic, antiangiogenic. In prostate cancer,

its effects appear to be on the cell cycle, stopping growth byupregulating [the tumor suppressor] p21. " > He is quick to add, " Yet we don't have a bit of data that I couldshow you to say it will work as a preventative. " Most of the evidence

is from ecologic, epidemiologic, and laboratory studies of cancers ofthe prostate, breast, colon, and pancreas. For now, the availablestudies in patients are treatment trials suggesting that vitamin Dmay heighten the effects of chemotherapy or radiation. There have

been few studies of vitamin D as a cancer chemopreventive.>> " The American Academy of Dermatology is not moved. A July 2003press release stated, " It is dangerous to mislead the public into

thinking that sunlight is a safe and effective 'cure' for otherhealth conditions. " AAD president L. Cornelison Jr., M.D.,suggested that people take a multivitamin or drink a few glasses ofvitamin D-fortified milk every day, adding, " the dangers of exposing

oneself to carcinogenic UV light from the sun, even for a fewminutes, are firmly established. " > " Is vitamin D insufficiency common? Yes. Is it likely acontributing factor to prostate, breast, colon, and maybe some other

cancers? Yes, " said Schwartz. " Am I saying 'get thee to a skintannery'? No. " >> " I'm not sure how the sun-versus-supplement issue will play out, " said Baron, whose study will include a questionnaire on sun exposure.

Welsh added, " It's still too early to know the right thing to do. " >> AND:> " Abstract> Vitamin D deficiency is more common than realized. It is making aresurgence in neonates and is common in black patients and older

adults. Vitamin D deficiency not only causes generalized muscleweakness, muscle aches, and bone aches and pains but also canprecipitate and exacerbate osteoporosis and cause osteomalacia.Although the kidney plays a critical role in producing 1,25-

dihydroxyvitamin D, which is important for regulating calcium,phosphorus, and bone metabolism, it is now recognized that a widevariety of other tissues have the enzymatic machinery to produce 1,25-dihydroxyvitamin D. Vitamin D receptors are common in most tissues in

the body, and the new revelation that many tissues produce 1,25-dihydroxyvitamin D suggests a new important role for this hormone inhelping to maintain good health throughout life.>> Probably the best description of vit D pathways is in:

> Holick, F. PhD, MD Vitamin D: the underappreciated D-lightful hormone that is important for skeletal and cellular health.Current Opinion in Endocrinology & Diabetes. 9(1):87-98, February2002.

> " Thus, in the absence of sufficient exposure to sunlight at least1000 IU of vitamin D/d is probably required to maintain a healthylevel of 25 (OH)D " >> This article suggests to me if I was concerned about D status, I

would get a blood test:>> Holick, F. MD, PHD Vitamin D: Important for Prevention ofOsteoporosis, Cardiovascular Heart Disease, Type 1 Diabetes,Autoimmune Diseases, and Some Cancers. Southern Medical Journal. 98

(10):1024-1026, October 2005.> " > Abstract:> Vitamin D is very important for overall health and well-being. Amajor source of vitamin D comes from exposure to sunlight.Measurement of 25-hydroxyvitamin D in the blood and not 1,25-

dihydroxyvitamin D is used to determine vitamin D status. A bloodlevel of 25-hydroxyvitamin D of at least 20 ng/mL is considered to bevitamin D sufficient. Vitamin D deficiency increases the risk of manycommon cancers, multiple sclerosis, rheumatoid arthritis,

hypertension, cardiovascular heart disease, and type I diabetes. " >> Key Points> * Ninety percent or more of our vitamin D requirement comes fromexposure to sunlight. Without sun exposure, 1,000 IU of vitamin D per

day is required. " >> I went thru this a cupla months ago and satisfied myself I had noworry, but I added 800 IU to try it. The result was I think there maybe a selection problem in which pill to take. I notice they are

adding D3 to the orange juice calling it 25% of RDA.>> I must stick with the RDA until the powers sort it out.>> Regards.>

[Guest guest]

Hi Rodney-

As of today, still on 1-3K units D3/day. Blood pressue has been OK (106/76), but I'm considering dropping most all supplements, at least for a while, just 'cause.

I'll continue to monitor.

Thanks!

On 1/30/06, Rodney <perspect1111@...> wrote:

Hey :IIRC you are taking very substantial vitamin D supplements. Are youstill? I am sure you have checked your BP. Is it OK?

Have you had other tests done that might be relevant to vitamin D?Such as serum Ca, or serum vitamin D?What do you think? We need your help here, imo.Thank you.Rodney.--- In , " jwwright " <jwwright@e...>wrote:>> I suggest those concerned with vit D read:>

http://www.ajcn.org/cgi/content/full/69/5/842#R16> the refs ate the end of doc contain a lot of useful info.> And the 53 articles cited by this article at the very end presentthe state of knowledge (or lack of) and

> http://darwin.nap.edu/books/0309085373/html/1320.html> shows the RDA at 9 yrs past the first article.>> Many of these are full text, and by the time I read all these, two

things I THINK :> " The evidence suggests that efforts to improve vitamin D status,for example by vitamin D supplementation, could reduce cancerincidence and mortality at low cost, with few or no adverse effects. "

>> " Vitamin D status differs by latitude and race, with residents ofthe northeastern United States and individuals with more skinpigmentation being at increased risk of deficiency. " >

> The first I don't have full text, but perhaps this one sums up thecancer story:> Journal of the National Cancer Institute> Volume 96(10), 19 May 2004, pp 735-736>> " " There's more to this vitamin D story, " said Lieberman,

M.D., program director of the Prostate and Urologic Cancer ResearchGroup in the National Cancer Institute's Division of CancerPrevention. " It is fascinating as a molecule. It's been shown to beantiproliferative, proapoptotic, antiangiogenic. In prostate cancer,

its effects appear to be on the cell cycle, stopping growth byupregulating [the tumor suppressor] p21. " > He is quick to add, " Yet we don't have a bit of data that I couldshow you to say it will work as a preventative. " Most of the evidence

is from ecologic, epidemiologic, and laboratory studies of cancers ofthe prostate, breast, colon, and pancreas. For now, the availablestudies in patients are treatment trials suggesting that vitamin Dmay heighten the effects of chemotherapy or radiation. There have

been few studies of vitamin D as a cancer chemopreventive.>> " The American Academy of Dermatology is not moved. A July 2003press release stated, " It is dangerous to mislead the public into

thinking that sunlight is a safe and effective 'cure' for otherhealth conditions. " AAD president L. Cornelison Jr., M.D.,suggested that people take a multivitamin or drink a few glasses ofvitamin D-fortified milk every day, adding, " the dangers of exposing

oneself to carcinogenic UV light from the sun, even for a fewminutes, are firmly established. " > " Is vitamin D insufficiency common? Yes. Is it likely acontributing factor to prostate, breast, colon, and maybe some other

cancers? Yes, " said Schwartz. " Am I saying 'get thee to a skintannery'? No. " >> " I'm not sure how the sun-versus-supplement issue will play out, " said Baron, whose study will include a questionnaire on sun exposure.

Welsh added, " It's still too early to know the right thing to do. " >> AND:> " Abstract> Vitamin D deficiency is more common than realized. It is making aresurgence in neonates and is common in black patients and older

adults. Vitamin D deficiency not only causes generalized muscleweakness, muscle aches, and bone aches and pains but also canprecipitate and exacerbate osteoporosis and cause osteomalacia.Although the kidney plays a critical role in producing 1,25-

dihydroxyvitamin D, which is important for regulating calcium,phosphorus, and bone metabolism, it is now recognized that a widevariety of other tissues have the enzymatic machinery to produce 1,25-dihydroxyvitamin D. Vitamin D receptors are common in most tissues in

the body, and the new revelation that many tissues produce 1,25-dihydroxyvitamin D suggests a new important role for this hormone inhelping to maintain good health throughout life.>> Probably the best description of vit D pathways is in:

> Holick, F. PhD, MD Vitamin D: the underappreciated D-lightful hormone that is important for skeletal and cellular health.Current Opinion in Endocrinology & Diabetes. 9(1):87-98, February2002.

> " Thus, in the absence of sufficient exposure to sunlight at least1000 IU of vitamin D/d is probably required to maintain a healthylevel of 25 (OH)D " >> This article suggests to me if I was concerned about D status, I

would get a blood test:>> Holick, F. MD, PHD Vitamin D: Important for Prevention ofOsteoporosis, Cardiovascular Heart Disease, Type 1 Diabetes,Autoimmune Diseases, and Some Cancers. Southern Medical Journal. 98

(10):1024-1026, October 2005.> " > Abstract:> Vitamin D is very important for overall health and well-being. Amajor source of vitamin D comes from exposure to sunlight.Measurement of 25-hydroxyvitamin D in the blood and not 1,25-

dihydroxyvitamin D is used to determine vitamin D status. A bloodlevel of 25-hydroxyvitamin D of at least 20 ng/mL is considered to bevitamin D sufficient. Vitamin D deficiency increases the risk of manycommon cancers, multiple sclerosis, rheumatoid arthritis,

hypertension, cardiovascular heart disease, and type I diabetes. " >> Key Points> * Ninety percent or more of our vitamin D requirement comes fromexposure to sunlight. Without sun exposure, 1,000 IU of vitamin D per

day is required. " >> I went thru this a cupla months ago and satisfied myself I had noworry, but I added 800 IU to try it. The result was I think there maybe a selection problem in which pill to take. I notice they are

adding D3 to the orange juice calling it 25% of RDA.>> I must stick with the RDA until the powers sort it out.>> Regards.>