Re: Caloric Restriction extends life

[Guest guest]

Hi folks:

By curious coincidence just a week ago I emailed the first-listed

author of the paper these people wrote in 2003 to ask if they had

updated data! (No reply so far). At that time they only had 117

monkeys. Now they have 300 apparently.

In any event, a 30% expansion in lifespan (the article does not

specify maximal lifespan) in Rhesus monkeys in response to CR,

certainly does seem to argue against the views of those who say that

in humans CR is likely to extend lifespan by only a couple of years.

To make that argument when comparing humans with fruit flies was very

plausible; with mice, much less convincing; and in monkeys, beginning

to stretch the limits of credulity!

BRAVO!

Rodney.

>

> " The price of leanness is eternal vigilance, " said Hansen, who

> presented her research Friday at the annual meeting of the American

> Association for the Advancement of Science.

>

> Hansen has long studied the effects of calorie restriction in

roughly

> 300 rhesus monkeys.

>

> Cutting calories can pay off when it comes to longevity: Monkeys fed

> 30 percent less over the long term extended their lifetimes to 30

> years from an average of 23 years, Hansen said.

>

> The slimmer monkeys staved off the diabetes, high cholesterol,

> hypertension and other weight-related ailments that typically

> shortened the lives of their heavier peers, she added.

>

> http://abcnews.go.com/Health/wireStory?id=1634128

>

[Guest guest]

Hi folks:

By curious coincidence just a week ago I emailed the first-listed

author of the paper these people wrote in 2003 to ask if they had

updated data! (No reply so far). At that time they only had 117

monkeys. Now they have 300 apparently.

In any event, a 30% expansion in lifespan (the article does not

specify maximal lifespan) in Rhesus monkeys in response to CR,

certainly does seem to argue against the views of those who say that

in humans CR is likely to extend lifespan by only a couple of years.

To make that argument when comparing humans with fruit flies was very

plausible; with mice, much less convincing; and in monkeys, beginning

to stretch the limits of credulity!

BRAVO!

Rodney.

>

> " The price of leanness is eternal vigilance, " said Hansen, who

> presented her research Friday at the annual meeting of the American

> Association for the Advancement of Science.

>

> Hansen has long studied the effects of calorie restriction in

roughly

> 300 rhesus monkeys.

>

> Cutting calories can pay off when it comes to longevity: Monkeys fed

> 30 percent less over the long term extended their lifetimes to 30

> years from an average of 23 years, Hansen said.

>

> The slimmer monkeys staved off the diabetes, high cholesterol,

> hypertension and other weight-related ailments that typically

> shortened the lives of their heavier peers, she added.

>

> http://abcnews.go.com/Health/wireStory?id=1634128

>

[Guest guest]

Rodney reports:

The slimmer monkeys staved off the diabetes, high cholesterol,

hypertension and other weight-related ailments that typically

shortened the lives of their heavier peers, she added.

When the stardard lab diet is deleterious enough to produce such

results in ad lib fed animals (conditions presumably unknown in wild

animals), we should not see it as positive proof of the efficacy of

calorie restriction when an animal regains some mesure of health

because he is fed less of it. It will be generally well accepted among

us that an ad lib optimal nutrition diet will be far healthier than a

mere CR diet composed of junk food. The question remains open, in my

mind at least, whether CR significantly potentiates ON. There is

enough out there to believe it does. But 30% extension in lifespan?

Again , a diet which results in diabetes is no where near an ON diet

and a 30% increase just by limiting acces to such food is no great

achievement.

> >

> > " The price of leanness is eternal vigilance, " said Hansen, who

> > presented her research Friday at the annual meeting of the American

> > Association for the Advancement of Science.

> >

> > Hansen has long studied the effects of calorie restriction in

> roughly

> > 300 rhesus monkeys.

> >

> > Cutting calories can pay off when it comes to longevity: Monkeys fed

> > 30 percent less over the long term extended their lifetimes to 30

> > years from an average of 23 years, Hansen said.

> >

> > The slimmer monkeys staved off the diabetes, high cholesterol,

> > hypertension and other weight-related ailments that typically

> > shortened the lives of their heavier peers, she added.

> >

> > http://abcnews.go.com/Health/wireStory?id=1634128

> >

>

[Guest guest]

Rodney reports:

The slimmer monkeys staved off the diabetes, high cholesterol,

hypertension and other weight-related ailments that typically

shortened the lives of their heavier peers, she added.

When the stardard lab diet is deleterious enough to produce such

results in ad lib fed animals (conditions presumably unknown in wild

animals), we should not see it as positive proof of the efficacy of

calorie restriction when an animal regains some mesure of health

because he is fed less of it. It will be generally well accepted among

us that an ad lib optimal nutrition diet will be far healthier than a

mere CR diet composed of junk food. The question remains open, in my

mind at least, whether CR significantly potentiates ON. There is

enough out there to believe it does. But 30% extension in lifespan?

Again , a diet which results in diabetes is no where near an ON diet

and a 30% increase just by limiting acces to such food is no great

achievement.

> >

> > " The price of leanness is eternal vigilance, " said Hansen, who

> > presented her research Friday at the annual meeting of the American

> > Association for the Advancement of Science.

> >

> > Hansen has long studied the effects of calorie restriction in

> roughly

> > 300 rhesus monkeys.

> >

> > Cutting calories can pay off when it comes to longevity: Monkeys fed

> > 30 percent less over the long term extended their lifetimes to 30

> > years from an average of 23 years, Hansen said.

> >

> > The slimmer monkeys staved off the diabetes, high cholesterol,

> > hypertension and other weight-related ailments that typically

> > shortened the lives of their heavier peers, she added.

> >

> > http://abcnews.go.com/Health/wireStory?id=1634128

> >

>