Fats & prostate cancer spread

[Guest guest]

Maybe, how healthy are our fats matter in whether we males develop the

metastases

that lead to death from prostate cancer, suggests the below paper, which is not

pdf-available until it is in a regularissue of the jounal. Increasing the

omega-3/-6 ratio is the action to be taken? Consuming marine versus land animal

fat

intake may be beneficial.

Brown MD, Hart CA, Gazi E, Bagley S, e NW.

Promotion of prostatic metastatic migration towards human bone marrow stoma by

Omega

6 and its inhibition by Omega 3 PUFAs.

Br J Cancer. 2006 Mar 7; [Epub ahead of print]

PMID: 16523199

Epidemiological studies have shown not only a relationship between the intake of

dietary lipids and an increased risk of developing metastatic prostate cancer,

but

also the type of lipid intake that influences the risk of metastatic prostate

cancer. The Omega-6 poly-unsaturated fatty acid, Arachidonic acid, has been

shown to

enhance the proliferation of malignant prostate epithelial cells and increase

the

risk of advanced prostate cancer. However, its role in potentiating the

migration of

cancer cells is unknown. Here we show that arachidonic acid at concentrations

</=5

muM is a potent stimulator of malignant epithelial cellular invasion, which is

able

to restore invasion toward hydrocortisone-deprived adipocyte-free human bone

marrow

stroma completely. This observed invasion is mediated by the arachidonic acid

metabolite prostaglandin E(2) and is inhibited by the Omega-3 poly-unsaturated

fatty

acids eicosapentaenoic acid and docosahexaenoic acid at a ratio of 1 : 2 Omega-3

:

Omega-6, and by the COX-2 inhibitor NS-398. These results identify a mechanism

by

which arachidonic acid may potentiate the risk of metastatic migration and

secondary

implantation in vivo, a risk which can be reduced with the uptake of Omega-3

poly-unsaturated fatty acids.

-- Al Pater, alpater@...

__________________________________________________

[Guest guest]

I think this article deals with those who have PCA and the risk of advancing to metastases, rather than developing PCA to begin with.

Regards.

[ ] Fats & prostate cancer spread

Maybe, how healthy are our fats matter in whether we males develop the metastasesthat lead to death from prostate cancer, suggests the below paper, which is notpdf-available until it is in a regularissue of the jounal. Increasing theomega-3/-6 ratio is the action to be taken? Consuming marine versus land animal fatintake may be beneficial.Brown MD, Hart CA, Gazi E, Bagley S, e NW.Promotion of prostatic metastatic migration towards human bone marrow stoma by Omega6 and its inhibition by Omega 3 PUFAs.Br J Cancer. 2006 Mar 7; [Epub ahead of print]PMID: 16523199Epidemiological studies have shown not only a relationship between the intake ofdietary lipids and an increased risk of developing metastatic prostate cancer, butalso the type of lipid intake that influences the risk of metastatic prostatecancer. The Omega-6 poly-unsaturated fatty acid, Arachidonic acid, has been shown toenhance the proliferation of malignant prostate epithelial cells and increase therisk of advanced prostate cancer. However, its role in potentiating the migration ofcancer cells is unknown. Here we show that arachidonic acid at concentrations </=5muM is a potent stimulator of malignant epithelial cellular invasion, which is ableto restore invasion toward hydrocortisone-deprived adipocyte-free human bone marrowstroma completely. This observed invasion is mediated by the arachidonic acidmetabolite prostaglandin E(2) and is inhibited by the Omega-3 poly-unsaturated fattyacids eicosapentaenoic acid and docosahexaenoic acid at a ratio of 1 : 2 Omega-3 :Omega-6, and by the COX-2 inhibitor NS-398. These results identify a mechanism bywhich arachidonic acid may potentiate the risk of metastatic migration and secondaryimplantation in vivo, a risk which can be reduced with the uptake of Omega-3poly-unsaturated fatty acids.-- Al Pater, alpater@...

[Guest guest]

I think this article deals with those who have PCA and the risk of advancing to metastases, rather than developing PCA to begin with.

Regards.

[ ] Fats & prostate cancer spread

Maybe, how healthy are our fats matter in whether we males develop the metastasesthat lead to death from prostate cancer, suggests the below paper, which is notpdf-available until it is in a regularissue of the jounal. Increasing theomega-3/-6 ratio is the action to be taken? Consuming marine versus land animal fatintake may be beneficial.Brown MD, Hart CA, Gazi E, Bagley S, e NW.Promotion of prostatic metastatic migration towards human bone marrow stoma by Omega6 and its inhibition by Omega 3 PUFAs.Br J Cancer. 2006 Mar 7; [Epub ahead of print]PMID: 16523199Epidemiological studies have shown not only a relationship between the intake ofdietary lipids and an increased risk of developing metastatic prostate cancer, butalso the type of lipid intake that influences the risk of metastatic prostatecancer. The Omega-6 poly-unsaturated fatty acid, Arachidonic acid, has been shown toenhance the proliferation of malignant prostate epithelial cells and increase therisk of advanced prostate cancer. However, its role in potentiating the migration ofcancer cells is unknown. Here we show that arachidonic acid at concentrations </=5muM is a potent stimulator of malignant epithelial cellular invasion, which is ableto restore invasion toward hydrocortisone-deprived adipocyte-free human bone marrowstroma completely. This observed invasion is mediated by the arachidonic acidmetabolite prostaglandin E(2) and is inhibited by the Omega-3 poly-unsaturated fattyacids eicosapentaenoic acid and docosahexaenoic acid at a ratio of 1 : 2 Omega-3 :Omega-6, and by the COX-2 inhibitor NS-398. These results identify a mechanism bywhich arachidonic acid may potentiate the risk of metastatic migration and secondaryimplantation in vivo, a risk which can be reduced with the uptake of Omega-3poly-unsaturated fatty acids.-- Al Pater, alpater@...