Curcumin on the invasiveness of prostate cancer

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Prostate Cancer Prostatic Dis. 2006 Jan 3; [Epub ahead

of print]

The effects of curcumin on the invasiveness of

prostate cancer in vitro and in vivo.

Hong JH, Ahn KS, Bae E, Jeon SS, Choi HY.

1Department of Urology, Samsung Medical Center,

Sungkyunkwan University School of Medicine, Seoul,

South Korea.

Curcumin has become a focus of interest with regard to

its antitumor effects in prostate cancer; however, the

effects of this agent on invasion and metastasis

remain less well understood. Matrix metalloproteinases

(MMPs) are important prerequisite for tumor invasion

and metastasis. In this study, we evaluated the

effects of curcumin on prostate cancer cells (DU-145)

invasion in both in vitro and in vivo. We utilized

zymography and ELISA in order to determine the MMP-2

and MMP-9 activity. Matrigel invasion assay was

performed to assess cellular invasion. We developed a

xenograft model to examine tumorigenicity. Curcumin

treatment resulted not only in a significant reduction

in the expression of MMP-2 and MMP-9, but also

effected the inhibition of invasive ability in vitro.

Curcumin was shown to induce a marked reduction of

tumor volume, MMP-2, and MMP-9 activity in the

tumor-bearing site. The metastatic nodules in vivo

were significantly fewer in the curcumin-treated group

than untreated group. Curcumin appears to constitute a

potential agent for the prevention of cancer

progression, or at least of the initial phase of

metastasis, in prostate cancer.Prostate Cancer and

Prostatic Diseases advance online publication, 3

January 2006; doi:10.1038/sj.pcan.4500856.

PMID: 16389264 [PubMed - as supplied by publisher]

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