Hiperinsulinemic or hipoinsulinemic DBT obesity

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According to scientists at the University of California, San Diego (UCSD) School of Medicine, a single gene encoding the enzyme GnT-4a glycosyltransferase (GnT-4a) is key to enabling the beta cells in the pancreas to sense blood glucose levels and appropriately produce insulin. However, this enzyme is suppressed by a high-fat diet, resulting in pancreatic beta cell failure and eventually leading to type 2 diabetes. Last week I posted question about the genesis of adult diabetic diseases obesity linked. I thought that obesity is a hiperinsulinemic disease with insulin resistence with direct correlations with visceral adiposity. The paper of San Diego seems

to be the opposite or I maybee miss something?

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