Re: An Individual's Degree of Adherence to CR

[Guest guest]

One of the hallmark characteristics is low WBC, which I hope is on your list.

As for some of the others, they vary so much from individual to individual. Take the obese mice as an example. They were still large on CR, but smaller than they would have been ad lib. Another example: My own BP is 120/70 - not exceptionally low for a CRONIE. But given my age and family history, pretty darn low. I could probalby get it lower if I lost another 5 lbs, but then I'm entering our of the zone of the healthiest BMI's (presently my BMI is about 19)

on 3/29/2006 1:31 PM, Rodney at perspect1111@... wrote:

To understand how 'percentage CR' is calculated, take systolic blood

pressure as an example: The WUSTL subjects had SBP averaging 99.

The WUSTL controls averaged 129. So 129 is taken to represent zero

adherence to CR for this variable, while a reading of 99 would

represent 100% CR. Other measurements for SBP score

proportionately. A reading of 114, for example, would represent 50%

CR since it is half way between 99 and 129. Any reading above 129

would represent a negative value of adherence to CR. Readings below

99 would give a result of greater than 100%.

[Guest guest]

One of the hallmark characteristics is low WBC, which I hope is on your list.

As for some of the others, they vary so much from individual to individual. Take the obese mice as an example. They were still large on CR, but smaller than they would have been ad lib. Another example: My own BP is 120/70 - not exceptionally low for a CRONIE. But given my age and family history, pretty darn low. I could probalby get it lower if I lost another 5 lbs, but then I'm entering our of the zone of the healthiest BMI's (presently my BMI is about 19)

on 3/29/2006 1:31 PM, Rodney at perspect1111@... wrote:

To understand how 'percentage CR' is calculated, take systolic blood

pressure as an example: The WUSTL subjects had SBP averaging 99.

The WUSTL controls averaged 129. So 129 is taken to represent zero

adherence to CR for this variable, while a reading of 99 would

represent 100% CR. Other measurements for SBP score

proportionately. A reading of 114, for example, would represent 50%

CR since it is half way between 99 and 129. Any reading above 129

would represent a negative value of adherence to CR. Readings below

99 would give a result of greater than 100%.

[Guest guest]

Hi Francesca:

Thanks for making the point about WBC. The reason it wasn't in there

is that I do not know where to find the benchmarks for it. The data

do not seem to have been collected in the WUSTL study. So if someone

can find a reasonably authoritative source for the typical 100% CRON

WBC level; and the standard ordinary zero percent CRON WBC reading, I

will certainly add it to the list, and modify the program

accordingly.

As for the variations in individual indicators, that is the point of

adding up the data for a large number (~a dozen) of variables. Then

if some are a bit above expected and others a bit below, it should

all even out overall. Much better, in other words, than basing such

an assessment on just a couple of variables. In your case, for

example, your lower than CRON-average BMI may make up for the

somewhat higher BP.

Rodney.

>

>

> To understand how 'percentage CR' is calculated, take systolic blood

> pressure as an example: The WUSTL subjects had SBP averaging 99.

> The WUSTL controls averaged 129. So 129 is taken to represent zero

> adherence to CR for this variable, while a reading of 99 would

> represent 100% CR. Other measurements for SBP score

> proportionately. A reading of 114, for example, would represent 50%

> CR since it is half way between 99 and 129. Any reading above 129

> would represent a negative value of adherence to CR. Readings below

> 99 would give a result of greater than 100%.

>

[Guest guest]

Hi Francesca:

Thanks for making the point about WBC. The reason it wasn't in there

is that I do not know where to find the benchmarks for it. The data

do not seem to have been collected in the WUSTL study. So if someone

can find a reasonably authoritative source for the typical 100% CRON

WBC level; and the standard ordinary zero percent CRON WBC reading, I

will certainly add it to the list, and modify the program

accordingly.

As for the variations in individual indicators, that is the point of

adding up the data for a large number (~a dozen) of variables. Then

if some are a bit above expected and others a bit below, it should

all even out overall. Much better, in other words, than basing such

an assessment on just a couple of variables. In your case, for

example, your lower than CRON-average BMI may make up for the

somewhat higher BP.

Rodney.

>

>

> To understand how 'percentage CR' is calculated, take systolic blood

> pressure as an example: The WUSTL subjects had SBP averaging 99.

> The WUSTL controls averaged 129. So 129 is taken to represent zero

> adherence to CR for this variable, while a reading of 99 would

> represent 100% CR. Other measurements for SBP score

> proportionately. A reading of 114, for example, would represent 50%

> CR since it is half way between 99 and 129. Any reading above 129

> would represent a negative value of adherence to CR. Readings below

> 99 would give a result of greater than 100%.

>

[Guest guest]

Hi folks:

The 'normal' range for WBC seems to depend on who you talk to. But

two similar ranges I have seen are 3.4 - 10 k/microL; and 4.3 - 10.8

k/microL.

I also found a study in which the data, based on quartiles, seem to

suggest the average population WBC is about 7.0.

It is an interesting study for other reasons too, because it shows a

clear direct relationship between WBC and cancer. And what is more

the full text is available free at:

http://cebp.aacrjournals.org/cgi/content/full/13/6/1052

So unless someone comes up with a brighter idea, I will use 7.0 as

the population average for WBC in the calculations I do for measuring

degree of adherence to CR. Now I still need the a WBC value for the

equivalent of the eighteen WUSTL subjects. Any ideas on that would

be appreciated.

Rodney.

> >

> >

> > To understand how 'percentage CR' is calculated, take systolic

blood

> > pressure as an example: The WUSTL subjects had SBP averaging 99.

> > The WUSTL controls averaged 129. So 129 is taken to represent

zero

> > adherence to CR for this variable, while a reading of 99 would

> > represent 100% CR. Other measurements for SBP score

> > proportionately. A reading of 114, for example, would represent

50%

> > CR since it is half way between 99 and 129. Any reading above 129

> > would represent a negative value of adherence to CR. Readings

below

> > 99 would give a result of greater than 100%.

> >

>

[Guest guest]

Hi folks:

The 'normal' range for WBC seems to depend on who you talk to. But

two similar ranges I have seen are 3.4 - 10 k/microL; and 4.3 - 10.8

k/microL.

I also found a study in which the data, based on quartiles, seem to

suggest the average population WBC is about 7.0.

It is an interesting study for other reasons too, because it shows a

clear direct relationship between WBC and cancer. And what is more

the full text is available free at:

http://cebp.aacrjournals.org/cgi/content/full/13/6/1052

So unless someone comes up with a brighter idea, I will use 7.0 as

the population average for WBC in the calculations I do for measuring

degree of adherence to CR. Now I still need the a WBC value for the

equivalent of the eighteen WUSTL subjects. Any ideas on that would

be appreciated.

Rodney.

> >

> >

> > To understand how 'percentage CR' is calculated, take systolic

blood

> > pressure as an example: The WUSTL subjects had SBP averaging 99.

> > The WUSTL controls averaged 129. So 129 is taken to represent

zero

> > adherence to CR for this variable, while a reading of 99 would

> > represent 100% CR. Other measurements for SBP score

> > proportionately. A reading of 114, for example, would represent

50%

> > CR since it is half way between 99 and 129. Any reading above 129

> > would represent a negative value of adherence to CR. Readings

below

> > 99 would give a result of greater than 100%.

> >

>