Nicotinamide (Vitamin B3) may increase replicative lifespan, says Virginia Tech

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Heh, this is "short communication" from a biochemistry lab at Virginia Tech, but they showed that nicotinamide, otherwise known as Vitamin B3, increased the number of times that human "primary fibroblasts" could divide before they "petered out" and stopped dividing. Click Here! This finding is interesting on many levels, especially to "Sir2" wonks who know that in yeast, this same compound would DECREASE replicative lifepan. Obviously, humans are built to deal with Vitamin B3 in ways that are conducive to longevity of the overall organism, which would make sense for large multicellular organisms that have the feeding patterns that we do. When we eat food, food that was once a "living thing", it may have a lot of vitamin B3 in it, so if vitamin B3 were to "age us", then trouble would ensue. So, somewhere in the course of evolution, this particular biochemical curiosity seen in yeast was "swept away" by the advent of humanity.However, it remains to be seen if supplementation is warranted. Some research with B vitamins suggests you simply should not try to get it from pills, aside from maybe B12. T. pct35768@...